Results 251 to 260 of about 19,535 (297)

Effects of a Four‐Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial

Movement Disorders, EarlyView.
Abstract Background Gut dysbiosis and gut‐brain‐axis involvement in people with Parkinson's disease (PwP) support the use of gut‐microbiota‐modulating interventions. Probiotics may help manage constipation in PwP; however, mechanisms underpinning additional beneficial properties are unknown.
Valentina Leta, Pavlos Zinzalias, Lucia Batzu, Gargi Mandal, Juliet Staunton, Frida Jernstedt, Kristina Rosqvist, Jonathan Timpka, Trinette van Vliet, Dhaval Trivedi, Aleksandra Podlewska, Miriam Parry, Daniel J. van Wamelen, Alexandra Rizos, Carolina Sportelli, Ana Laura Bonder, Guy Chung‐Faye, Cristian Falup‐Pecurariu, Simon Gaisford, Edoardo Moretto, Gwenaelle Le Gall, David Vauzour, Ana Rodriguez‐Mateos, Anna Sauerbier, Carmen Rodriguez Blazquez, Jonas Ghyselinck, Benoît Marsaux, Carmine Maria Pariante, Alessandra Borsini, Per Odin, Kallol Ray Chaudhuri   +30 more
wiley   +1 more source

How Surgeons Think to Avoid Error: A Case Study of the Neurovascular Bundle Sparing During a Robotic Prostatectomy

Avril Lusty, Janet Alexanian, Simon Kitto, Timothy J. Wood, Luke T. Lavallée, Christopher Morash, Ilias Cagiannos, Rodney H. Breau, Isabelle Raîche   +8 more
openalex   +1 more source

INTRAOPERATIVE HISTOLOGICAL FROZEN-SECTION EXAMINATION OF PROSTATE REGIONS ADJACENT TO NEUROVASCULAR BUNDLE: INITIAL IMPLEMENTATION EXPERIENCE DURING ROBOTIC-ASSISTED RADICAL PROSTATECTOMY

, 2019
Sokolov Ea, Е. И. Велиев, Oxana Paklina, GRIGORY V. KNYSHINSKY   +3 more
openalex   +1 more source

AZP2006 in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open‐Label Extension on Safety, Biomarkers, and Disease Progression

Movement Disorders, EarlyView.
Abstract Objectives The aim was to evaluate the safety, tolerability, pharmacokinetics, and potential clinical efficacy of AZP2006, an oral pleiotropic drug modulating progranulin levels, in patients with progressive supranuclear palsy (PSP), a rare tauopathy. Methods A randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted at
Jean‐Christophe Corvol, Mickael Alexandre Obadia, Caroline Moreau, Louise‐Laure Mariani, Jean‐Philippe Brandel, David Devos, Sara Sambin, Nicolas Carrière, Günter Höglinger, Marie Lebouteux, Graziella Mangone, Noelle Callizot, Aurélien Blondel, Olivier Defert, Cecilia Estrella, Artin Karapet, Philippe Verwaerde, Luc Defebvre   +17 more
wiley   +1 more source

RRP12 Variants Are Associated With Autosomal Recessive Brain Calcifications

Movement Disorders, EarlyView.
Abstract Background Primary brain calcifications are observed in several inherited diseases due to different pathogenic mechanisms, including the disruption of the neurovascular unit, mitochondrial dysfunction, and impaired nucleic acid metabolism.
Edoardo Monfrini, Paola Rinchetti, Mathieu Anheim, Anna Klingseisen, Ouhaid Lagha‐Boukbiza, Zhidong Cen, Dehao Yang, Xinhui Chen, Reza Maroofian, Henry Houlden, Gioia Cappelletti, Anne‐Claire Richard, Olivier Quenez, Camilo Toro, Steven J. Frucht, Francesco Lotti, Wei Luo, David Hunt, Gael Nicolas, Giulietta M. Riboldi   +19 more
wiley   +1 more source

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abundantly expressed in MSNs, is a promising biomarker of striatal integrity, but region‐specific associations and its potential for early‐stage ...
Mena Farag, Michael J. Murphy, Nicola Z. Hobbs, Michela Leocadi, Kate Fayer, Olivia Thackeray, Johan Gobom, Marc Ciosi, Amanda Heslegrave, Henrik Zetterberg, Douglas R. Langbehn, Darren G. Monckton, Edward J. Wild, Sarah J. Tabrizi, Rachael I. Scahill   +14 more
wiley   +1 more source

Preoperative Functional Connectivity Predicts Antiparkinson Drug Change after Deep Brain Stimulation

Movement Disorders, EarlyView.
Abstract Background Deep brain stimulation (DBS) can effectively ameliorate motor symptoms in Parkinson's disease (PD), but patient outcomes remain variable. Clinical predictors lack reliability and only explain a small proportion of outcome variance, outlining a need for biomarkers that can enhance prediction accuracy.
David Mikhael, Skyler Deutsch, Juhi Mehta, Sarah Wang, John Kornak, Philip A. Starr, Jill L. Ostrem, Doris D. Wang, Ian O. Bledsoe, Melanie A. Morrison   +9 more
wiley   +1 more source

Shaeer’s hydro-inflation technique for neurovascular bundle mobilization during penile surgery [PDF]

Osama Shaeer, Hossam El Debs, Amr Elahwany, Kamal Shaeer, Kamal Shaeer   +4 more
openalex   +1 more source

Systematic Review with Meta‐Analysis of Biofluid Markers for Huntington's Disease

Movement Disorders, EarlyView.
Eight Huntington's Disease Biofluid Markers show Meta‐Analytic Significance Across HD‐ISS Stages. Meta‐analyses were conducted for two types of biomarkers: Different from demographically‐matched healthy controls and *Showing change over time. Abstract Primary therapeutic objectives for Huntington's disease (HD) necessitate continued therapy for a long ...
Jane S. Paulsen, Natalie A. Bovin, Jordan D. Clemsen, Alexander Weiss, Abigail M. Key, Monica L. Janz, Alex Pinto, Deven K. Burks, Henrik Zetterberg, Kathleen M. Shannon   +9 more
wiley   +1 more source

Sympathetic Shift and Insular Alteration: Unravelling the Link Between Anxiety and Heart Rate Variability in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Anxiety and autonomic dysfunction are frequent non‐motor symptoms of Parkinson's disease (PD). Their relationship, as well as the neural mechanisms underlying this relationship, remain unexplored. Objectives We aimed to investigate the relationship between cardiovascular functions and anxiety in PD and the structural neural changes ...
Lucia Ricciardi, Alessandra Fanciulli, Francescopaolo P. Cucinotta, Bryony Ishihara, Ioana Cociasu, Fahd Baig, Michael Hart, Erlick Pereira, Francesca Morgante, Elena Makovac   +9 more
wiley   +1 more source