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Retinal Neurovascular Coupling in Diabetes [PDF]
Journal of Clinical Medicine, 2020 Neurovascular coupling, also termed functional hyperemia, is one of the physiological key mechanisms to adjust blood flow in a neural tissue in response to functional activity.
Gerhard Garhofer +2 more
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Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer’s disease
Brain, 2022 To match the metabolic demands of the brain, mechanisms have evolved to couple neuronal activity to vasodilation, thus increasing local cerebral blood flow and delivery of oxygen and glucose to active neurons.
Winston M Zhu +2 more
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Neurovascular coupling and distribution of cerebral blood flow during exercise
Journal of Neuroscience Methods, 2011 We examined how cerebral blood flow velocity (CBV) and neurovascular coupling is influenced by exercise. Blood velocities in the posterior and middle cerebral arteries (PCAv and MCAv) during rest and cycling exercise at 60% estimated maximal oxygen ...
C K Willie, P N Ainslie, C E Taylor
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Heritability of brain neurovascular coupling
Journal of Neurophysiology, 2022Here we show that the sample-to-sample turnover of the resting state fMRI blood-oxygen-level-dependent turnover (TBOLD) is heritable, the left and right hemisphere TBOLD heritabilities are highly correlated, and TBOLD heritability varies among cortical areas.
Peka Christova +2 more
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Spreading Depression and Neurovascular Coupling [PDF]
Stroke, 2013 Spreading depression, discovered by Leao in 1944,1 is an intense depolarization wave that slowly propagates (≈3 mm/min) in gray matter by way of contiguity, regardless of functional divisions or arterial territories. The depolarization is associated with massive transmembrane ionic and water shifts coupled to a surge in extracellular K+ and ...
Cenk Ayata
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Nitric oxide is fundamental to neurovascular coupling in humans
Journal of Physiology, 2020 KEY POINTS: Preclinical models have demonstrated that nitric oxide is a key component of neurovascular coupling; this has yet to be translated to humans.
Ryan L Hoiland +2 more
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Neurovascular coupling: motive unknown
Trends in Neurosciences, 2022In the brain, increases in neural activity drive changes in local blood flow via neurovascular coupling. The common explanation for increased blood flow (known as functional hyperemia) is that it supplies the metabolic needs of active neurons. However, there is a large body of evidence that is inconsistent with this idea.
openaire +2 more sources
Is Neurovascular Coupling of Relevance in Glaucoma?
Survey of Ophthalmology, 2007Rapid development of functional neuroimaging techniques have brought about a growing interest for neurovascular coupling in neuroresearch, which, in turn, has prompted similar research in ophthalmology. There are now hints that neurovascular coupling is disturbed in glaucoma.
Konstantin, Gugleta +2 more
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Brain capillary pericytes and neurovascular coupling
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2021The neurovascular coupling ensures that cerebral activity is matched by the relevant blood flow. The control of the blood flow is mediated by capillaries and by the precapillary aterioles. It is the tone of the mural cells, which include pericytes, smooth muscle cells and cells with intermediate phenotypes between pericytes and smooth muscle cells ...
Grubb, Søren +2 more
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