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Oxidative Stress and the Neurovascular Unit [PDF]
Life, 2021 The neurovascular unit (NVU) is a relatively recent concept that clearly describes the relationship between brain cells and their blood vessels. The components of the NVU, comprising different types of cells, are so interrelated and associated with each ...
Carmela Rinaldi +5 more
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Pathology of the neurovascular unit in leukodystrophies [PDF]
Acta Neuropathologica Communications, 2021 The blood–brain barrier is a dynamic endothelial cell barrier in the brain microvasculature that separates the blood from the brain parenchyma. Specialized brain endothelial cells, astrocytes, neurons, microglia and pericytes together compose the ...
Parand Zarekiani +5 more
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Fibrinogen and Neuroinflammation in the Neurovascular Unit in Stroke. [PDF]
J Inflamm ResYi Chen,1 Lu Han,1 De-Sheng Zhu,1,2 Yang-Tai Guan1,3 1Department of Neurology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, People’s Republic of China; 2Department of Neurology, Baoshan Branch, Renji Hospital ...
Chen Y, Han L, Zhu DS, Guan YT.
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Neurovascular Unit Dysfunction and Neurodegenerative Disorders [PDF]
Frontiers in Neuroscience, 2020 The neurovascular unit (NVU), composed of vascular cells, glial cells, and neurons, is the minimal functional unit of the brain. The NVU maintains integrity of the blood–brain barrier (BBB) and regulates supply of the cerebral blood flow (CBF), both of ...
Xing Yu, Caihong Ji, Anwen Shao
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Toward three-dimensional in vitro models to study neurovascular unit functions in health and disease [PDF]
Neural Regeneration Research, 2021 The high metabolic demands of the brain require an efficient vascular system to be coupled with neural activity to supply adequate nutrients and oxygen. This supply is coordinated by the action of neurons, glial and vascular cells, known collectively as ...
Tara M Caffrey +2 more
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The neurovascular unit in leukodystrophies: towards solving the puzzle [PDF]
Fluids and Barriers of the CNS, 2022 The neurovascular unit (NVU) is a highly organized multicellular system localized in the brain, formed by neuronal, glial (astrocytes, oligodendrocytes, and microglia) and vascular (endothelial cells and pericytes) cells.
Bugiani, M +4 more
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How does neurovascular unit dysfunction contribute to multiple sclerosis?
Neurobiology of Disease, 2023 Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system (CNS) and the most common non-traumatic cause of neurological disability in young adults.
Jake M. Cashion +2 more
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Structure and function of neurovascular unit in arterial hypertension [PDF]
Frontiers in Molecular NeuroscienceArterial hypertension is considered a main risk factor for cognitive impairment and stroke. Although chronic hypertension leads to adaptive changes in the lager cerebral blood vessels which should protect the downstream microvessels, profound changes in ...
Ewa Kozniewska, Marta Aleksandrowicz
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Cells, 2022 Calcitonin-gene-related peptide (CGRP) plays a key role in migraine pathophysiology and more specifically in the mechanisms underlying peripheral and central sensitization.
Rosaria Greco +4 more
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Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine
The Journal of Headache and Pain, 2023 Cannabidiol (CBD) is the main pharmacologically active phytocannabinoid. CBD exerts an analgesic effect in several pain models, does not have side effects and has low toxicity. The data about CBD mechanisms of action in pain and its therapeutic potential
Rosaria Greco +9 more
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