Results 1 to 10 of about 4,031,569 (323)

Shaping the Neurovascular Unit Exploiting Human Brain Organoids. [PDF]

Mol Neurobiol
Brain organoids, three-dimensional cell structures derived from pluripotent stem cells, closely mimic key aspects of the human brain in vitro, providing a powerful tool for studying neurodevelopment and disease.
Rizzuti M, Melzi V, Brambilla L, Quetti L, Sali L, Ottoboni L, Meneri M, Ratti A, Verde F, Ticozzi N, Comi GP, Corti S, Abati E.   +12 more
europepmc   +2 more sources

The role of the neurovascular unit in vascular cognitive impairment: Current evidence and future perspectives

Neurobiology of Disease
Vascular cognitive impairment (VCI) is a progressive cognitive impairment caused by cerebrovascular disease or vascular risk factors. It is the second most common type of cognitive impairment after Alzheimer's disease. The pathogenesis of VCI is complex,
Zhidong He, Jing Sun
doaj   +2 more sources

The phase coherence of the neurovascular unit is reduced in Huntington’s disease [PDF]

Brain Commun
Huntington’s disease is a neurodegenerative disorder in which neuronal death leads to chorea and cognitive decline. Individuals with ≥40 cytosine–adenine–guanine repeats on the interesting transcript 15 gene develop Huntington’s disease due to a mutated ...
J. Bjerkan, J. Kobal, Gemma Lancaster, S. Šešok, B. Meglic, Peter V. E. McClintock, K. Budohoski, P. Kirkpatrick, A. Stefanovska   +8 more
europepmc   +2 more sources

Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine

The Journal of Headache and Pain, 2023
Cannabidiol (CBD) is the main pharmacologically active phytocannabinoid. CBD exerts an analgesic effect in several pain models, does not have side effects and has low toxicity. The data about CBD mechanisms of action in pain and its therapeutic potential
Rosaria Greco, Miriam Francavilla, Chiara Demartini, Anna Maria Zanaboni, Mikael H. Sodergren, Sara Facchetti, Barbara Pacchetti, Michela Palmisani, Valentina Franco, Cristina Tassorelli   +9 more
doaj   +1 more source

Antagonism of CGRP Receptor: Central and Peripheral Mechanisms and Mediators in an Animal Model of Chronic Migraine

Cells, 2022
Calcitonin-gene-related peptide (CGRP) plays a key role in migraine pathophysiology and more specifically in the mechanisms underlying peripheral and central sensitization.
Rosaria Greco, Chiara Demartini, Miriam Francavilla, Anna Maria Zanaboni, Cristina Tassorelli   +4 more
doaj   +1 more source

Impaired neuronal activity as a potential factor contributing to the underdeveloped cerebrovasculature in a young Parkinson’s disease mouse model

Scientific Reports, 2023
Misfolding of α-synuclein (α-Syn) in the brain causes cellular dysfunction, leading to cell death in a group of neurons, and consequently causes the progression of Parkinson’s disease (PD).
Jin-Young Jeong, Hyun Jung Lee, Namsuk Kim, Yan Li, Jong-Cheol Rah, Won-Jong Oh   +5 more
doaj   +1 more source

The Riga East University Hospital Stroke Registry—An Analysis of 4915 Consecutive Patients with Acute Stroke

Medicina, 2021
Background and Objectives: A hospital-based stroke registry is a useful tool for systematic analyses of the epidemiology, clinical characteristics, and natural course of stroke. Analyses of stroke registry data can provide information that can be used by
Guntis Karelis, Madara Micule, Evija Klavina, Iveta Haritoncenko, Ilga Kikule, Biruta Tilgale, Inese Polaka   +6 more
doaj   +1 more source

Functional Brain Imaging Based on the Neurovascular Unit for Evaluating Neural Networks after Strok [PDF]

Advanced Ultrasound in Diagnosis and Therapy, 2022
The exploration of human brain function has always been a research hotspot in the field of neuroscience. The concept of a neurovascular unit suggests that cerebral microcirculation can be used as a reliable signal to reflect neural function. Accordingly,
Yongyue Zhang, MM, Yang Sun, MM, Li Zhang, MM, Rongjin Zhang, MM, Shumin Wang, PhD
doaj   +1 more source

Translational challenges of remote ischemic conditioning in ischemic stroke – a systematic review

Annals of Clinical and Translational Neurology, 2021
Remote ischemic conditioning (RIC) has well‐established cardioprotective effects in preclinical studies and promising results in preclinical stroke research.
Line Fuglsang Hansen, Nicholine S. K. Nielsen, Laura Cathrine Christoffersen, Christina Kruuse   +3 more
doaj   +1 more source

Dual Inhibition of FAAH and MAGL Counteracts Migraine-like Pain and Behavior in an Animal Model of Migraine

Cells, 2021
The endocannabinoid system exerts an important role in pain processing and modulation. Modulation of the system with hydrolase inhibitors of anandamide (AEA) or 2-arachidonyl glycerol (2-AG) has proved effective in reducing migraine-like features in ...
Rosaria Greco, Chiara Demartini, Miriam Francavilla, Anna Maria Zanaboni, Cristina Tassorelli   +4 more
doaj   +1 more source