Results 21 to 30 of about 4,031,569 (323)
Neurovascular Unit in Chronic Pain [PDF]
Mediators of Inflammation, 2013 Chronic pain is a debilitating condition with major socioeconomic impact, whose neurobiological basis is still not clear. An involvement of the neurovascular unit (NVU) has been recently proposed.
Beatrice Mihaela Radu +6 more
doaj +5 more sources
Structure and function of neurovascular unit in arterial hypertension [PDF]
Frontiers in Molecular NeuroscienceArterial hypertension is considered a main risk factor for cognitive impairment and stroke. Although chronic hypertension leads to adaptive changes in the lager cerebral blood vessels which should protect the downstream microvessels, profound changes in ...
Ewa Kozniewska, Marta Aleksandrowicz
doaj +2 more sources
Nano Letters, 2023 Oxidative stress is known to be the cause of several neurovascular diseases, including neurodegenerative disorders, since the increase of reactive oxygen species (ROS) levels can lead to cellular damage, blood–brain barrier leaking, and inflammatory ...
Giulia Tarricone +9 more
semanticscholar +3 more sources
Neurovascular Unit Dysfunction and Neurodegenerative Disorders [PDF]
Frontiers in Neuroscience, 2020 The neurovascular unit (NVU), composed of vascular cells, glial cells, and neurons, is the minimal functional unit of the brain. The NVU maintains integrity of the blood–brain barrier (BBB) and regulates supply of the cerebral blood flow (CBF), both of ...
Xing Yu, Caihong Ji, Anwen Shao
doaj +3 more sources
Microfluidic models of the neurovascular unit: a translational view. [PDF]
Fluids Barriers CNS, 2023 The vasculature of the brain consists of specialized endothelial cells that form a blood-brain barrier (BBB). This barrier, in conjunction with supporting cell types, forms the neurovascular unit (NVU). The NVU restricts the passage of certain substances
Wevers NR, De Vries HE.
europepmc +2 more sources
Microglia-Mediated Neurovascular Unit Dysfunction in Alzheimer’s Disease
Journal of Alzheimer’s Disease, 2023 The neurovascular unit (NVU) is involved in the pathological changes in Alzheimer’s disease (AD). The NVU is a structural and functional complex that maintains microenvironmental homeostasis and metabolic balance in the central nervous system.
Wen-Jun Huang +10 more
semanticscholar +3 more sources
Neurovascular Unit: A critical role in ischemic stroke
CNS Neuroscience and Therapeutics, 2021 Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health.
Liyun Wang +3 more
semanticscholar +3 more sources
In Situ Detection of Neuroinflammation Using Multicellular 3D Neurovascular‐Unit‐on‐a‐Chip
Advanced Functional Materials, 2023 The human neurovascular system is a complex network of blood vessels and brain cells that is essential to the proper functioning of the brain. Researchers have become increasingly interested in the system for developing drugs to treat neuroinflammation ...
Jin‐Ha Choi +2 more
semanticscholar +3 more sources
Pathology of the neurovascular unit in leukodystrophies [PDF]
Acta Neuropathologica Communications, 2021 The blood–brain barrier is a dynamic endothelial cell barrier in the brain microvasculature that separates the blood from the brain parenchyma. Specialized brain endothelial cells, astrocytes, neurons, microglia and pericytes together compose the ...
Parand Zarekiani +5 more
doaj +5 more sources
The Neurovascular Unit Dysfunction in Alzheimer’s Disease [PDF]
International Journal of Molecular Sciences, 2021 Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide. Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and aggregates of amyloid β peptide (Aβ) both in the brain parenchyma as neuritic ...
Luis O. Soto-Rojas +9 more
semanticscholar +4 more sources