Results 21 to 30 of about 32,728 (256)
Aging and the neurovascular unit [PDF]
Annals of the New York Academy of Sciences, 2012 With the demonstration that acute recanalization of obstructed symptomatic cerebral arteries during ischemic stroke can result in substantial improvement in clinical outcome, the variability in clinical responses, and in hemorrhagic transformation, requires attention.
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Validation of Repeated Endothelial Function Measurements Using EndoPAT in Stroke
Frontiers in Neurology, 2017 BackgroundDecreased endothelial function (EF) may be a prognostic marker for stroke. Measuring pharmacological effects on EF may be of interest in the development of personalized medicine for stroke prevention.
Aina S. Hansen +4 more
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TWEAK and Fn14 in the Neurovascular Unit [PDF]
Frontiers in Immunology, 2013 The neurovascular unit (NVU) is a dynamic structure assembled by endothelial cells (EC), a basement membrane (BM), perivascular astrocytes (PA), pericytes, and surrounding neurons. The NVU regulates the passage of substances and cellular elements from the intravascular space into the brain parenchyma.
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The Neurovascular Unit Dysfunction in Alzheimer’s Disease [PDF]
International Journal of Molecular Sciences, 2021 Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide. Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and aggregates of amyloid β peptide (Aβ) both in the brain parenchyma as neuritic plaques, and around blood vessels as cerebral amyloid angiopathy (CAA).
Luis O. Soto-Rojas +9 more
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Factors associated with abnormal cerebral blood flow in Egyptian children with sickle cell disease
Clinical and Translational Neuroscience, 2020 Background: Transcranial Doppler (TCD) is a well-established tool for cerebrovascular assessment. Estimating the flow velocity across the intracranial arteries helps to identify children with sickle cell anaemia who are at risk for stroke. Objective: Our
Foad Abd-Allah +10 more
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The Journal of Headache and Pain, 2022 Targeting fatty acid amide hydrolase (FAAH) is a promising therapeutic strategy to combat certain forms of pain, including migraine headache. FAAH inhibitors, such as the O-biphenyl-3-yl carbamate URB597, have been shown to produce anti-hyperalgesic ...
Rosaria Greco +8 more
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Injury and repair in the neurovascular unit [PDF]
Neurological Research, 2012 The neurovascular unit provides a conceptual framework for investigating the pathophysiology of how brain cells die after stroke, brain injury, and neurodegeneration. Emerging data now suggest that this concept can be further extended. Cell-cell signaling between neuronal, glial, and vascular elements in the brain not only mediates the mechanisms of ...
Changhong, Xing +4 more
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tPA and Proteolysis in the Neurovascular Unit [PDF]
Stroke, 2004 One of the major recommendations emerging from the NINDS Stroke Progress Review Group was to shift the emphasis from a purely neurocentric view of cell death toward a more integrative approach whereby responses in all brain cells and matrix are considered during cerebral ischemia (see Figure).
Eng H, Lo +2 more
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Vasculo-Neuronal Coupling and Neurovascular Coupling at the Neurovascular Unit: Impact of Hypertension [PDF]
Frontiers in Physiology, 2020 Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates cerebral blood flow and maintain brain homeostasis. Here, we describe evidence for cells of the NVU contributing to critical physiological processes such as cerebral autoregulation, neurovascular coupling, and vasculo-neuronal coupling.
Jessica L. Presa +4 more
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Nature Communications, 2023 The anion channel SLAC1 functions as a crucial effector in the ABA signaling, leading to stomata closure. SLAC1 is activated by phosphorylation in its intracellular domains.
Yeongmok Lee +10 more
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