Results 11 to 20 of about 4,031,569 (323)

Neurovascular unit, neuroinflammation and neurodegeneration markers in brain disorders. [PDF]

Front Cell Neurosci
Neurovascular unit (NVU) inflammation via activation of glial cells and neuronal damage plays a critical role in neurodegenerative diseases. Though the exact mechanism of disease pathogenesis is not understood, certain biomarkers provide valuable insight
Kempuraj D, Dourvetakis KD, Cohen J, Valladares DS, Joshi RS, Kothuru SP, Anderson T, Chinnappan B, Cheema AK, Klimas NG, Theoharides TC.   +10 more
europepmc   +4 more sources

Oxidative Stress and the Neurovascular Unit [PDF]

Life, 2021
The neurovascular unit (NVU) is a relatively recent concept that clearly describes the relationship between brain cells and their blood vessels. The components of the NVU, comprising different types of cells, are so interrelated and associated with each ...
Carmela Rinaldi, Luigi Donato, Simona Alibrandi, Concetta Scimone, Rosalia D’Angelo, Antonina Sidoti   +5 more
doaj   +6 more sources

Revisiting the neurovascular unit

Nature Neuroscience, 2021
The brain is supplied by an elaborate vascular network that originates extracranially and reaches deep into the brain. The concept of the neurovascular unit provides a useful framework to investigate how neuronal signals regulate nearby microvessels to support the metabolic needs of the brain, but it does not consider the role of larger cerebral ...
Samantha M Schaeffer, C. Iadecola
semanticscholar   +5 more sources

Research developments in the neurovascular unit and the blood‑brain barrier (Review). [PDF]

Biomed Rep
The neurovascular unit (NVU) is composed of neurons, glial cells, brain microvascular endothelial cells (BMECs), pericytes, and the extracellular matrix.
Gong Y, Wu M, Huang Y, He X, Yuan J, Dang B.   +5 more
europepmc   +2 more sources

Layer-specific anatomical and physiological features of the retina's neurovascular unit. [PDF]

Curr Biol
SUMMARY The neurovascular unit (NVU), comprising vascular, glial, and neural elements, supports the energetic demands of neural computation, but this aspect of the retina’s trilaminar vessel network is poorly understood.
Grimes WN, Berson DM, Sabnis A, Hoon M, Sinha R, Tian H, Diamond JS.   +6 more
europepmc   +2 more sources

Subarachnoid Hemorrhage, Spreading Depolarizations and Impaired Neurovascular Coupling [PDF]

Stroke Research and Treatment, 2013
Aneurysmal subarachnoid hemorrhage (SAH) has devastating consequences on brain function including profound effects on communication between neurons and the vasculature leading to cerebral ischemia.
Masayo Koide, Inna Sukhotinsky, Cenk Ayata, George C. Wellman   +3 more
doaj   +4 more sources

A microengineered 3D human neurovascular unit model to probe the neuropathogenesis of herpes simplex encephalitis. [PDF]

Nat Commun
Herpes simplex encephalitis (HSE) caused by HSV-1 is the most common non-epidemic viral encephalitis, and the neuropathogenesis of HSE remains elusive.
Zhang M, Wang P, Wu Y, Jin L, Liu J, Deng P, Luo R, Chen X, Zhao M, Zhang X, Guo Y, Yan Y, Di Y, Qin J.   +13 more
europepmc   +2 more sources

The pleiotropic effects of statins: a comprehensive exploration of neurovascular unit modulation and blood-brain barrier protection. [PDF]

Mol Med
The blood–brain barrier (BBB) is the most central component of the neurovascular unit (NVU) and is crucial for the maintenance of the internal environment of the central nervous system and the regulation of homeostasis.
Liu JC, Lei SY, Zhang DH, He QY, Sun YY, Zhu HJ, Qu Y, Zhou SY, Yang Y, Li C, Guo ZN.   +10 more
europepmc   +2 more sources

How does neurovascular unit dysfunction contribute to multiple sclerosis?

Neurobiology of Disease, 2023
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system (CNS) and the most common non-traumatic cause of neurological disability in young adults.
Jake M. Cashion, Kaylene M. Young, Brad A. Sutherland   +2 more
doaj   +2 more sources

The microcirculation, the blood-brain barrier, and the neurovascular unit in health and Alzheimer disease: The aberrant pericyte is a central player. [PDF]

Pharmacol Rev
High fidelity neuronal signaling is enabled by a stable local microenvironment. A high degree of homeostatic regulation of the brain microenvironment, and its separation from the variable and potentially neurotoxic contents of the blood, is brought about
Divecha YA, Rampes S, Tromp S, Boyanova ST, Fleckney A, Fidanboylu M, Thomas SA.   +6 more
europepmc   +2 more sources