Results 41 to 50 of about 32,728 (256)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto +12 more
wiley +1 more source
Elevated plasma levels of alpha-synuclein are dispensable for Parkinson’s disease pathology
npj Parkinson's DiseaseAlthough α-synuclein levels are elevated in the blood plasma of Parkinson’s disease (PD) patients, it remains unclear whether blood-derived α-synuclein directly contributes to PD.
Jin-Young Jeong +5 more
doaj +1 more source
Brain, Behavior, & Immunity - Health, 2023 The neurovascular unit, comprised of vascular cell types that collectively regulate cerebral blood flow to meet the needs of coupled neurons, is paramount for the proper function of the central nervous system. The neurovascular unit gatekeeps blood-brain
Marina Wakid +11 more
doaj +1 more source
Targeting the Neurovascular Unit in Brain Trauma [PDF]
CNS Neuroscience & Therapeutics, 2014 SummaryAlthough the neurovascular unit was originally developed as a conceptual framework for stroke, it is now recognized that these cell–cell interactions play critical roles in many other CNS disorders as well. In brain trauma, perturbations within the neurovascular unit may be especially important.
Josephine, Lok +10 more
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos +9 more
wiley +1 more source
Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle +4 more
wiley +1 more source
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon +5 more
wiley +1 more source
Neural Regeneration Research, 2019 Previous studies have shown that models of depression exhibit structural and functional changes to the neurovascular unit. Thus, we hypothesized that diabetes-related depression might be associated with damage to the hippocampal neurovascular unit.
Jian Liu +6 more
doaj +1 more source
Ultrastructure of Precapillary Sphincters and the Neurovascular Unit
Vascular Biology, 2022 Abstract Neurons communicate with vasculature to regulate blood flow in the brain. The cells that maintain this are collectively named the neurovascular unit (NVU). This communication, known as neurovascular coupling, is thought to involve astrocytes or molecules that can pass through the astrocytic endfeet. However, the exact mechanism
openaire +4 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes +75 more
wiley +1 more source