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Møte i Styret for BIBSYS-konsortiet 19-02-2021 [PDF]

, 2021
Saksdokumenter for møte i Styret for BIBSYS-konsortiet 19/02 2021Saksdokumenter for møte i Styret for BIBSYS-konsortiet 19/02 ...
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Making Connexons in the Neurovascular Unit [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2012
Less than a decade ago, the term blood–brain barrier underwent a major conceptual change when it was recognized that the cerebrovasculature was anything, but passive in its structure and function. Instead of a layer of bricks separated by heavy mortar, the brain endothelial cell became one of a complement of cell types performing together as a dynamic,
openaire   +2 more sources

Interaction of Microglia and Astrocytes in the Neurovascular Unit [PDF]

Frontiers in Immunology, 2020
The interaction between microglia and astrocytes significantly influences neuroinflammation. Microglia/astrocytes, part of the neurovascular unit (NVU), are activated by various brain insults. The local extracellular and intracellular signals determine their characteristics and switch of phenotypes.
Li-rong Liu, Li-rong Liu, Jia-chen Liu, Jin-shuang Bao, Qin-qin Bai, Gai-qing Wang, Gai-qing Wang   +6 more
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Endocytic BDNF secretion regulated by Vamp3 in astrocytes

Scientific Reports, 2021
Brain-derived neurotrophic factor (BDNF) regulates diverse brain functions via TrkB receptor signaling. Due to the expression of TrkB receptors, astrocytes can internalize extracellular BDNF proteins via receptor-mediated endocytosis.
Jeongho Han, Sungryeong Yoon, Hyungju Park   +2 more
doaj   +1 more source

Spreading depression as an innate antiseizure mechanism

Nature Communications, 2021
Spreading depression is a prolonged depolarization in the CNS associated with several neurological diseases. Here the authors demonstrate a reciprocal relationship between spreading depression and seizures in an animal model.
Isra Tamim, David Y. Chung, Andreia Lopes de Morais, Inge C. M. Loonen, Tao Qin, Amrit Misra, Frieder Schlunk, Matthias Endres, Steven J. Schiff, Cenk Ayata   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

The neurovascular unit in the setting of stroke [PDF]

Journal of Internal Medicine, 2010
del Zoppo GJ (University of Washington, Seattle, WA, USA). The neurovascular unit in the setting of stroke (Review). J Intern Med 2010; 267: 156–171.Abstract.  Microvessels and neurons respond rapidly and simultaneously in focal regions of ischaemic injury in such a way as to suggest that the responses could be coordinated.
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Elevated plasma levels of alpha-synuclein are dispensable for Parkinson’s disease pathology

npj Parkinson's Disease
Although α-synuclein levels are elevated in the blood plasma of Parkinson’s disease (PD) patients, it remains unclear whether blood-derived α-synuclein directly contributes to PD.
Jin-Young Jeong, Namsuk Kim, Yan Li, Doo-Jin Kim, Hyong Kyu Kim, Won-Jong Oh   +5 more
doaj   +1 more source

Universal method for the isolation of microvessels from frozen brain tissue: A proof-of-concept multiomic investigation of the neurovasculature

Brain, Behavior, & Immunity - Health, 2023
The neurovascular unit, comprised of vascular cell types that collectively regulate cerebral blood flow to meet the needs of coupled neurons, is paramount for the proper function of the central nervous system. The neurovascular unit gatekeeps blood-brain
Marina Wakid, Daniel Almeida, Zahia Aouabed, Reza Rahimian, Maria Antonietta Davoli, Volodymyr Yerko, Elena Leonova-Erko, Vincent Richard, René Zahedi, Christoph Borchers, Gustavo Turecki, Naguib Mechawar   +11 more
doaj   +1 more source