Results 51 to 60 of about 2,245,425 (289)

Making Connexons in the Neurovascular Unit [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2012
Less than a decade ago, the term blood–brain barrier underwent a major conceptual change when it was recognized that the cerebrovasculature was anything, but passive in its structure and function. Instead of a layer of bricks separated by heavy mortar, the brain endothelial cell became one of a complement of cell types performing together as a dynamic,
openaire   +2 more sources

Interaction of Microglia and Astrocytes in the Neurovascular Unit [PDF]

Frontiers in Immunology, 2020
The interaction between microglia and astrocytes significantly influences neuroinflammation. Microglia/astrocytes, part of the neurovascular unit (NVU), are activated by various brain insults. The local extracellular and intracellular signals determine their characteristics and switch of phenotypes.
Li-rong Liu, Li-rong Liu, Jia-chen Liu, Jin-shuang Bao, Qin-qin Bai, Gai-qing Wang, Gai-qing Wang   +6 more
openaire   +3 more sources

Endocytic BDNF secretion regulated by Vamp3 in astrocytes

Scientific Reports, 2021
Brain-derived neurotrophic factor (BDNF) regulates diverse brain functions via TrkB receptor signaling. Due to the expression of TrkB receptors, astrocytes can internalize extracellular BDNF proteins via receptor-mediated endocytosis.
Jeongho Han, Sungryeong Yoon, Hyungju Park   +2 more
doaj   +1 more source

The neurovascular unit in COSC.

, 2013
Immunohistochemical stainings show a preserved morphology of astrocytes and pericytes that cover cortical microvessels in COSC (A). Stainings with the neuronal marker NeuN demonstrated a preserved neuronal morphology within the neurovascular unit of COSC
Christoph M. Zehendner (294872), Hannah E. Wedler (488380), Heiko J. Luhmann (294868)   +2 more
core   +1 more source

Spreading depression as an innate antiseizure mechanism

Nature Communications, 2021
Spreading depression is a prolonged depolarization in the CNS associated with several neurological diseases. Here the authors demonstrate a reciprocal relationship between spreading depression and seizures in an animal model.
Isra Tamim, David Y. Chung, Andreia Lopes de Morais, Inge C. M. Loonen, Tao Qin, Amrit Misra, Frieder Schlunk, Matthias Endres, Steven J. Schiff, Cenk Ayata   +9 more
doaj   +1 more source

The Role of the Microbiome and the Neurovascular Unit. [PDF]

Surg Clin North Am
The gut-brain axis plays a crucial role in neurovascular diseases, linking gut microbiota to blood-brain barrier integrity, neuroinflammation, and disease progression. Conditions such as cerebral cavernous malformations, traumatic brain injury, radiation-induced damage, and stroke exhibit microbiome-driven modulation that may be relevant to explain ...
Polster SP.
europepmc   +3 more sources

Discrete Event Simulation of Patient Admissions to a Neurovascular Unit [PDF]

, 2018
Evidence exists that clinical outcomes improve for stroke patients admitted to specialized Stroke Units. The Toronto Western Hospital created a Neurovascular Unit (NVU) using beds from general internal medicine, Neurology and Neurosurgery to care for ...
Casaubon, L. K., Tan, P., Chow, E., Appel, E., Abrams, H. B., Carter, M. W., Hahn-Goldberg, S., Ko, F. T. F., Ng, T., Gavin, M. B.   +9 more
core   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Additional file 1 of Modeling ischemic stroke in a triculture neurovascular unit on-a-chip

, 2021
Additional file 1. Schematic representation of the neurovascular unit model in the OrganoPlate. (a) Picture of the OrganoPlate 3-lane culture platform, comprising 40 tissue culture chips.
Dhanesh G. Kasi (11837809), Remko van Vught (9026951), Arya Lekshmi Nair (11837800), Gwenaëlle Rabussier (11837818), Maria Pontier (11837806), Paul Vulto (1761424), Xandor M. Spijkers (11837812), Henriëtte L. Lanz (11837821), Helga E. de Vries (6661445), Nienke R. Wevers (11837797), Charlie Hallard (11837815), Tania M. Fowke (11837803)   +11 more
core   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source