Results 51 to 60 of about 4,031,569 (323)

Autophagy in the retinal neurovascular unit: New perspectives into diabetic retinopathy

open access: yesJournal of Diabetes, 2023
Diabetic retinopathy (DR) is one of the most prevalent retinal disorders worldwide, and it is a major cause of vision impairment in individuals of productive age.
Xiongyi Yang   +6 more
semanticscholar   +1 more source

Aging and the neurovascular unit [PDF]

open access: yesAnnals of the New York Academy of Sciences, 2012
With the demonstration that acute recanalization of obstructed symptomatic cerebral arteries during ischemic stroke can result in substantial improvement in clinical outcome, the variability in clinical responses, and in hemorrhagic transformation, requires attention.
openaire   +2 more sources

Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine

open access: yesThe Journal of Headache and Pain, 2022
Targeting fatty acid amide hydrolase (FAAH) is a promising therapeutic strategy to combat certain forms of pain, including migraine headache. FAAH inhibitors, such as the O-biphenyl-3-yl carbamate URB597, have been shown to produce anti-hyperalgesic ...
Rosaria Greco   +8 more
doaj   +1 more source

The neurovascular unit in healthy and injured spinal cord

open access: yesJournal of Cerebral Blood Flow and Metabolism, 2023
The neurovascular unit (NVU) reflects the close temporal and spatial link between neurons and blood vessels. However, the understanding of the NVU in the spinal cord is far from clear and largely based on generalized knowledge obtained from the brain ...
Rubing Zhou   +4 more
semanticscholar   +1 more source

Ultrastructure of neurovascular changes in human diabetic retinopathy [PDF]

open access: yes, 2018
The previous concept regarding diabetic retinopathy assigned a primary role to hyperglycemia-induced microvascular alterations, while neuronal and glial abnormalities were considered to be secondary to either ischemia or exudation.
Artico, Marco   +9 more
core   +1 more source

Effects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets

open access: yesPediatric Research, 2023
The neurovascular unit (NVU) within the brain is a multicellular unit that synergistically acts to maintain blood–brain barrier function and meet cerebral metabolic demand.
Bing Wu   +6 more
semanticscholar   +1 more source

Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation [PDF]

open access: yes, 2016
Brain endothelial cells constitute the major cellular element of the highly specialized blood–brain barrier (BBB) and thereby contribute to CNS homeostasis by restricting entry of circulating leukocytes and blood-borne molecules into the CNS.
Arie Reijerkerk   +6 more
core   +3 more sources

Awake chronic mouse model of targeted pial vessel occlusion via photothrombosis [PDF]

open access: yes, 2020
Animal models of stroke are used extensively to study the mechanisms involved in the acute and chronic phases of recovery following stroke. A translatable animal model that closely mimics the mechanisms of a human stroke is essential in understanding ...
Boas, David A.   +9 more
core   +1 more source

Imaging the neurovascular unit in health and neurodegeneration: a scoping review of interdependencies between MRI measures

open access: yesFluids and Barriers of the CNS, 2023
The neurovascular unit (NVU) is a complex structure that facilitates nutrient delivery and metabolic waste clearance, forms the blood–brain barrier (BBB), and supports fluid homeostasis in the brain.
E. Rowsthorn   +5 more
semanticscholar   +1 more source

Cryo-EM structures of the plant anion channel SLAC1 from Arabidopsis thaliana suggest a combined activation model

open access: yesNature Communications, 2023
The anion channel SLAC1 functions as a crucial effector in the ABA signaling, leading to stomata closure. SLAC1 is activated by phosphorylation in its intracellular domains.
Yeongmok Lee   +10 more
doaj   +1 more source

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