Results 71 to 80 of about 34,675 (249)

Linkage of alternative exon assembly in Drosophila TrpA1 transcripts

Molecules and Cells
: Drosophila TrpA1 (transient receptor potential ankyrin 1) transcripts are alternatively spliced at 2 distinct sites each with a choice of mutually exclusive exons.
Eun Jo Du, MinHyuk Lee, Seon Yeong Kim, Se Hoon Park, Hye-Jung Ohk, KyeongJin Kang   +5 more
doaj   +1 more source

Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging

, 2016
The neurovascular unit, which protects neuronal cells and supplies them with essential molecules, plays an important role in the pathophysiology of Alzheimer's Disease (AD).
Hofman, P.A.M., Osch, M.J.P. van, van Osch, Matthias J.P., Verhey, Frans R.J., Jansen, J.F.A., Wong, May, Wong, Sau May, Jansen, Jaap; id_orcid, Hofman, Paul A. M., Jansen, Jacobus F.A., Muller, M., van Buchem, Mark A., Muller, Majon, Wong, S.M., Hofman, Paul A.M., Buchem, M.A. van, Verhey, Frans R. J., Haar, H.J. van de, Jansen, Jaap, Verhey, F.R.J., van de Haar, Harm J., van Osch, Matthias J. P., Burgmans, Saartje, Burgmans, S., Backes, Walter H., Backes, W.H.   +25 more
core   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Educational inequalities in stroke knowledge and symptom recognition following a national Danish stroke campaign: a cross-sectional study

BMC Public Health
Introduction Public stroke campaigns may have informational gaps, which are essential to identify to improve outcomes in stroke awareness and response. We evaluated the impact of a national stroke campaign on knowledge of stroke, and symptom recognition,
Hannah Andersen, Heidi Shil Eddelien, Malini Sagar, Stine Strandkjaer, Else Foverskov, Christina Kruuse   +5 more
doaj   +1 more source

Examination of Inter‐α Inhibitor Proteins in Permanent and Transient Focal Ischemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Ischemic stroke is among the most prevalent diseases, with high death and morbidity. Numerous preclinical studies have reported efficacious interventions in rodent stroke models.
Takahiko Imai, Andreia Lopes de Morais, Tao Qin, Yuichi Sasaki, Yow‐Pin Lim, Cenk Ayata   +5 more
doaj   +1 more source

Table_1_Aging Neurovascular Unit and Potential Role of DNA Damage and Repair in Combating Vascular and Neurodegenerative Disorders.DOCX

, 2019
Progressive neurological deterioration poses enormous burden on the aging population with ischemic stroke and neurodegenerative disease patients, such as Alzheimers’ disease and Parkinson’s disease. The past two decades have witnessed remarkable advances
Peiying Li (797714), Yueman Zhang (7160432), Tingting Huang (496866), Yan Li (23143), Lv Xie (5872859), Bo Qi (630839), Xin Wang (91924), Zengai Chen (7160435), Jie Zhou (28945)   +8 more
core   +1 more source

Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation

Advanced Science, EarlyView.
Sleep deprivation progressively shifts human brain dynamics from near‐critical toward supercritical states, as revealed by neuronal avalanche analysis of resting‐state fMRI. These changes track subjective sleep pressure rather than vigilance lapses and show marked network heterogeneity. A circuit model suggests that reduced inhibitory efficacy provides
Dai Zhang, Liqin Zhou, Rong Wang, Yuehua Han, Zhentao Zuo, Yanghua Tian, Ke Zhou   +6 more
wiley   +1 more source

Recycling of endocytic BDNF through extracellular vesicles in astrocytes

Scientific Reports
Brain-derived neurotrophic factor (BDNF) plays an essential role in regulating diverse neuronal functions in an activity-dependent manner. Although BDNF is synthesized primarily in neurons, astrocytes can also supply BDNF through various routes ...
Jeongho Han, Hyungju Park
doaj   +1 more source