Results 71 to 80 of about 4,031,569 (323)

Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification. [PDF]

, 2020
Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder characterized by a combination of neurological, psychiatric, and cognitive decline associated with calcium deposition on brain imaging. To date, mutations in five genes have
A. Athanasiou-Fragkouli, A. Begtrup, A. Bisgin, A. Carr, A. Pittman, A. Richard-Loendt, A. Verrotti, A.M. Ruiz, B. Cormand, B. Garavaglia, B. Kalmar, B. O&apos, B. Perez-Duenas, B.M. Karashova, B.M. Sanchez, C. Beetz, C. Macmillan, C. Scuderi, D. Avdjieva, D. Timmann, E. Borgione, E. Dardiotis, E. Torti, E.Z. Papanicolaou, F. Al-Mutairi, F. Launchbury, G. Di Rosa, G. Heimer, G. Hotton, G. Koutsis, G. Marseglia, G. McDonnell, G. Morello, H. Houlden, H. Kathom, H. Sherifa, I. Al-Khawaja, J. Althonayan, J. McKinley, J. Mine, J.H. Livingston, J.R. Mendes de Oliveira, J.S. Goraya, L. Arning, L. Greensmith, L.V. Schottlaender, M. Aurrand-Lions, M. Breza, M. de Grandis, M. Garcia-Silva, M. Pineda-Marfa, M. Vikelis, M. Zollo, M.D. Ferrari, M.P.M. Soutar, N.N. Rana, O. Atawneh, O. Swayne, P. Giunti, P. Striano, P. Veggiotti, P.J. Morrison, R. Abeti, R. Boles, R. Forbes, R. Maroofian, R. Tincheva, S. Banu, S. Boesch, S. Brandner, S. Efthymiou, S. Groppa, S. Ibrahim, S. Khan, S. Kirmani, S. Mangano, S. Maqbool, S. Papacostas, S. Portaro, S. Savasta, S. Tug Bozdogan, T. Stojkovic, T. Sultan, V. Chelban, W. Nachbauer, Y.A. Dauvilliers, Z. Jaunmuktane   +86 more
core   +8 more sources

Endocytic BDNF secretion regulated by Vamp3 in astrocytes

Scientific Reports, 2021
Brain-derived neurotrophic factor (BDNF) regulates diverse brain functions via TrkB receptor signaling. Due to the expression of TrkB receptors, astrocytes can internalize extracellular BDNF proteins via receptor-mediated endocytosis.
Jeongho Han, Sungryeong Yoon, Hyungju Park   +2 more
doaj   +1 more source

Neural activity with spatial and temporal correlations as a basis to simulate fMRI data [PDF]

, 2009
In the development of data analysis techniques, simulation studies are constantly gaining more interest. The largest challenge in setting up a simulation study is to create realistic data.
Rosseel, Yves, Welvaert, Marijke
core   +1 more source

Injury and repair in the neurovascular unit [PDF]

Neurological Research, 2012
The neurovascular unit provides a conceptual framework for investigating the pathophysiology of how brain cells die after stroke, brain injury, and neurodegeneration. Emerging data now suggest that this concept can be further extended. Cell-cell signaling between neuronal, glial, and vascular elements in the brain not only mediates the mechanisms of ...
Changhong, Xing, Kazuhide, Hayakawa, Josephine, Lok, Ken, Arai, Eng H, Lo   +4 more
openaire   +2 more sources

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke [PDF]

, 2014
Aims: Cerebral small vessel disease (SVD) causes a fifth of all strokes plus diffuse brain damage leading to cognitive decline, physical disabilities and dementia.
Bailey, Emma L., Crawford, Wendy, Dominiczak, Anna F., Graham, Delyth, McBride, Martin W., McClure, John D., Smith, Colin, Sudlow, Cathie L.M., Wardlaw, Joanna M.   +8 more
core   +2 more sources

Ultrastructural Remodeling of the Blood–Brain Barrier and Neurovascular Unit by Lipopolysaccharide-Induced Neuroinflammation

International Journal of Molecular Sciences, 2023
The blood–brain barrier (BBB) is an interface primarily comprised of brain endothelial cells (BECs), separating the central nervous system (CNS) from the systemic circulation while carefully regulating the transport of molecules and inflammatory cells ...
M. Erickson, Tatyana Shulyatnikova, W. Banks, M. Hayden   +3 more
semanticscholar   +1 more source

tPA and Proteolysis in the Neurovascular Unit [PDF]

Stroke, 2004
One of the major recommendations emerging from the NINDS Stroke Progress Review Group was to shift the emphasis from a purely neurocentric view of cell death toward a more integrative approach whereby responses in all brain cells and matrix are considered during cerebral ischemia (see Figure).
Eng H, Lo, Joseph P, Broderick, Michael A, Moskowitz   +2 more
openaire   +2 more sources

Spreading depression as an innate antiseizure mechanism

Nature Communications, 2021
Spreading depression is a prolonged depolarization in the CNS associated with several neurological diseases. Here the authors demonstrate a reciprocal relationship between spreading depression and seizures in an animal model.
Isra Tamim, David Y. Chung, Andreia Lopes de Morais, Inge C. M. Loonen, Tao Qin, Amrit Misra, Frieder Schlunk, Matthias Endres, Steven J. Schiff, Cenk Ayata   +9 more
doaj   +1 more source

Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier [PDF]

, 2016
According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor-related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to neurotoxic amyloid-beta (A beta) brain accumulation and drives ...
Alessandro Di Spiezio, Axel Heimann, Bell, Bouter, Bu, Carsten Korth, Claus U. Pietrzik, Deane, Deane, Dodart, Hahn, Heyser, Ingrid Prikulis, Ito, Ito, Ito, Julius N. Meißner, Julius Nahrath, Kanekiyo, Korth, Leneuve, Markus Schwaninger, Mc Donald, Nils Schubert, Qosa, Roosmarijn E. Vandenbroucke, Sabrina Meister, Sandra Baches, Sascha Weggen, Steffen E. Storck, Thomas A. Bayer, Tooyama, Tooyama, Wolf, Yvonne Bouter   +34 more
core   +2 more sources

The “Neuro-Glial-Vascular” Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction

Frontiers in Cell and Developmental Biology, 2021
The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes.
E. Kugler, J. Greenwood, R. MacDonald
semanticscholar   +1 more source