Results 91 to 100 of about 4,031,569 (323)

Targeting neuroinflammation in Alzheimer’s disease [PDF]

, 2016
Almost 47 million people suffer from dementia worldwide, with an estimated new case diagnosed every 3.2 seconds. Alzheimer’s disease (AD) accounts for approximately 60%–80% of all dementia cases. Given this evidence, it is clear dementia represents one
Bronzuoli, MARIA ROSANNA, Iacomino, Aniello, Scuderi, Caterina, Steardo, Luca   +3 more
core   +1 more source

A 3D Bioprinted Human Neurovascular Unit Model of Glioblastoma Tumor Growth

Advanced Healthcare Materials
A 3D bioprinted neurovascular unit (NVU) model is developed to study glioblastoma (GBM) tumor growth in a brain‐like microenvironment. The NVU model includes human primary astrocytes, pericytes and brain microvascular endothelial cells, and patient ...
Yen-Ting Tung, Yu-Chi Chen, K. Derr, Kelli M. Wilson, Min Jae Song, Marc Ferrer   +5 more
semanticscholar   +1 more source

Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood–brain barrier in acute ischemic stroke

Acta Neuropathologica, 2022
Blood–brain barrier (BBB) dysfunction, characterized by degradation of BBB junctional proteins and increased permeability, is a crucial pathophysiological feature of acute ischemic stroke.
Daniel Spitzer, S. Guérit, Tim Puetz, Maryam I. Khel, Moritz Armbrust, Maika Dunst, J. Macas, Jenny Zinke, Gayatri Devraj, Xiaoxiong Jia, Florian Croll, Kathleen Sommer, Katharina Filipski, Thomas M. Freiman, M. Looso, S. Günther, Mariangela Di Tacchio, Karlheinz Plate, Y. Reiss, S. Liebner, P. Harter, K. Devraj   +21 more
semanticscholar   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

Ultrastructure of Precapillary Sphincters and the Neurovascular Unit [PDF]

Vascular Biology, 2022
AbstractNeurons communicate with vasculature to regulate blood flow in the brain. The cells that maintain this are collectively named the neurovascular unit (NVU). This communication, known as neurovascular coupling, is thought to involve astrocytes or molecules that can pass through the astrocytic endfeet. However, the exact mechanism is still unclear.
openaire   +3 more sources

Management of Forehead Scars [PDF]

, 2017
This article provides an overview of scar management within the forehead region. It addresses the unique challenges specific to the treatment of forehead wounds. A logical, stepwise approach is used.
Bryant, Lucas M., Heffelfinger, Ryan N., Sanan, Akshay   +2 more
core   +2 more sources

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Laminar fMRI: applications for cognitive neuroscience [PDF]

, 2019
The cortex is a massively recurrent network, characterized by feedforward and feedback connections between brain areas as well as lateral connections within an area.
de Lange, Floris P., Formisano, Elia, Lawrence, Samuel J.D., Muckli, Lars   +3 more
core   +2 more sources

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Glioma-induced remodeling of the neurovascular unit [PDF]

Brain Research, 2009
The normal BBB (blood-brain barrier) consists of a series of structures collectively known as neurovascular units, or NVU, that are composed of endothelial cells and astrocyte endfeet separated by a basal lamina at their interface. The integrity of the BBB and specifically endothelial tight junctions is maintained by interactions between these ...
Jisook, Lee, Caren, Lund-Smith, Alexandra, Borboa, Ana M, Gonzalez, Andrew, Baird, Brian P, Eliceiri   +5 more
openaire   +2 more sources