Results 91 to 100 of about 2,245,425 (289)

A Murine Toolbox for Imaging the Neurovascular Unit [PDF]

Microcirculation, 2015
AbstractThe neurovascular unit (NVU) coordinates many essential functions in the brain including blood flow control, nutrient delivery, and maintenance of BBB integrity. These functions are the result of a cellular and molecular interplay that we are just beginning to understand.
David A, Hartmann, Robert G, Underly, Ashley N, Watson, Andy Y, Shih   +3 more
openaire   +2 more sources

Linkage of alternative exon assembly in Drosophila TrpA1 transcripts

Molecules and Cells
: Drosophila TrpA1 (transient receptor potential ankyrin 1) transcripts are alternatively spliced at 2 distinct sites each with a choice of mutually exclusive exons.
Eun Jo Du, MinHyuk Lee, Seon Yeong Kim, Se Hoon Park, Hye-Jung Ohk, KyeongJin Kang   +5 more
doaj   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Educational inequalities in stroke knowledge and symptom recognition following a national Danish stroke campaign: a cross-sectional study

BMC Public Health
Introduction Public stroke campaigns may have informational gaps, which are essential to identify to improve outcomes in stroke awareness and response. We evaluated the impact of a national stroke campaign on knowledge of stroke, and symptom recognition,
Hannah Andersen, Heidi Shil Eddelien, Malini Sagar, Stine Strandkjaer, Else Foverskov, Christina Kruuse   +5 more
doaj   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Recycling of endocytic BDNF through extracellular vesicles in astrocytes

Scientific Reports
Brain-derived neurotrophic factor (BDNF) plays an essential role in regulating diverse neuronal functions in an activity-dependent manner. Although BDNF is synthesized primarily in neurons, astrocytes can also supply BDNF through various routes ...
Jeongho Han, Hyungju Park
doaj   +1 more source

Examination of Inter‐α Inhibitor Proteins in Permanent and Transient Focal Ischemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Ischemic stroke is among the most prevalent diseases, with high death and morbidity. Numerous preclinical studies have reported efficacious interventions in rodent stroke models.
Takahiko Imai, Andreia Lopes de Morais, Tao Qin, Yuichi Sasaki, Yow‐Pin Lim, Cenk Ayata   +5 more
doaj   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

The Cell Regulation Mechanism of Neurovascular Unit [PDF]

, 2016
Ischemic cerebrovascular disease is one of the three deadly diseases. It is characterised by high mortality and high morbidity. Because of no effective treatments of recombinant tissue plasminogen activator (rt-PA) and neuroprotectant, there are more and
Yan, Han-Wen, Jia, Yuan-Yuan, Chang, Rui-Bi, Dai, Rong   +3 more
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