Results 101 to 110 of about 2,153,529 (297)

Selective regulation of corticostriatal synapses by astrocytic phagocytosis

Nature Communications
In the adult brain, neural circuit homeostasis depends on the constant turnover of synapses via astrocytic phagocytosis mechanisms. However, it remains unclear whether this process occurs in a circuit-specific manner.
Ji-young Kim, Hyeyeon Kim, Won-Suk Chung, Hyungju Park   +3 more
doaj   +1 more source

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

Aktivitets- og leveranseplan pensumlistekonsortiet 2021

, 2020
Aktivitets- og leveranseplan pensumlistekonsortiet 2021.Aktivitets- og leveranseplan pensumlistekonsortiet ...
Unit
core  

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Advanced Science, EarlyView.
Combined high‐glucose and hypoxic stress switches microglia into a TSPAN4‐dependent migrasome‐producing state. These migrasomes deliver pro‐angiogenic signals to endothelial cells, activating HIF‐1α/VEGF signaling, disrupting vascular junctions, and fueling pathological neovascularization. This work uncovers migrasome‐mediated immune‐vascular crosstalk
Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu, Hongying Li, Yuanyuan Fan, Haiyue Xie, Yangyang Lu, Yifan Lin, Xinjing Wu, Chengkun Wang, Ping Xie, Zizhong Hu   +12 more
wiley   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

Møte i Rådgivende gruppe for BIBSYS-konsortiet 19. februar 2020

, 2020
Møte i Rådgivende gruppe for BIBSYS-konsortiet 19. februar 2020 (epost-behandling).Møte i Rådgivende gruppe for BIBSYS-konsortiet 19. februar 2020 (epost-behandling)
Unit
core  

Referat styremøte pensumlistekonsortiet 21/09 2021

, 2021
Referat styremøte pensumlistekonsortiet 21/09 2021.Referat styremøte pensumlistekonsortiet 21/09 ...
Unit
core  

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Cryo-EM structures of mouse bestrophin 1 channel in closed and partially open conformations

Molecules and Cells
: Bestrophin 1 (BEST1) channels are calcium-activated Cl− channels involved in diverse physiological processes, including gliotransmitter release in astrocytes.
Kwon-Woo Kim, Euna Lee, Ara Ko, Junmo Hwang, Kunwoong Park, Byoung-Cheol Lee, Ki Woo Kim, Won-Jong Oh, Kyuhyung Kim, Hyun-Ho Lim   +9 more
doaj   +1 more source

Møte i Rådgivende gruppe for BIBSYS-konsortiet 31. mars 2020

, 2020
Møte i Rådgivende gruppe for BIBSYS-konsortiet 31. mars 2020.Møte i Rådgivende gruppe for BIBSYS-konsortiet 31.
Unit
core