Results 121 to 130 of about 2,153,529 (297)

Blood Biomarkers of Alzheimer's Disease and Patterns of Structural Brain Changes in the Community

Annals of Neurology, EarlyView.
Objective We aimed to investigate the associations between Alzheimer's disease (AD)‐related blood biomarkers and changes in brain volumes and cerebrovascular burden in community‐dwelling older adults. Methods We included 361 dementia‐free participants with a Mini‐Mental State Examination (MMSE) score ≥ 27 and without prior cerebrovascular events from a
Martina Valletta, Davide Liborio Vetrano, Erika J. Laukka, Grégoria Kalpouzos, Javier Oltra, Debora Rizzuto, Marco Canevelli, Claudia Fredolini, Chengxuan Qiu, Bengt Winblad, Laura Fratiglioni, Giulia Grande   +11 more
wiley   +1 more source

Bridging immune-neurovascular crosstalk via the immunomodulatory microspheres for promoting neural repair

Bioactive Materials
The crosstalk between immune cells and the neurovascular unit plays a pivotal role in neural regeneration following central nervous system (CNS) injury. Maintaining brain immune homeostasis is crucial for restoring neurovascular function.
Tongtong Xu, Lin Gan, Wei Chen, Dandan Zheng, Hanlai Li, Shiyu Deng, Dongliang Qian, Tingting Gu, Qianyuan Lian, Gracie Shen, Qingzhu An, Wanlu Li, Zhijun Zhang, Guo-Yuan Yang, Huitong Ruan, Wenguo Cui, Yaohui Tang   +16 more
doaj   +1 more source

Møte i arbeidsgruppen for Oria 28-11-2019

, 2019
Referat fra møte i arbeidsgruppen for Oria 28/11 2019.Referat fra møte i arbeidsgruppen for Oria 28/11 ...
Unit
core  

Toward a Behavioral Reserve Model in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Behavioral impairment is common in amyotrophic lateral sclerosis (ALS) and strongly affects autonomy, caregiver burden, and outcomes, yet predictors of vulnerability remain unclear. We investigated whether premorbid regulatory traits and socio‐educational exposures are associated with behavioral phenotypes in ALS within a behavioral reserve ...
Francesca Palumbo, Barbara Iazzolino, Cristina Moglia, Umberto Manera, Enrico Matteoni, Sara Cabras, Giorgio Pellegrino, Emilio Minerva, Vita Passidomo, Rosario Vasta, Gabriele Mora, Fabrizio D’Ovidio, Antonio Canosa, Andrea Calvo, Adriano Chiò   +14 more
wiley   +1 more source

Konsortiemøtet i pensumlistekonsortiet 2021

, 2021
Referat og sakspapirer fra konsortiemøtet i pensumlistekonsortiet 2021.Referat og sakspapirer fra konsortiemøtet i pensumlistekonsortiet ...
Unit
core  

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Referat styremøte pensumlistekonsortiet 31/03 2020

, 2020
Referat fra styremøte i pensumlistekonsortiet 31/3 2020.Referat fra styremøte i pensumlistekonsortiet 31/3 ...
Unit
core  

Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment

Annals of Neurology, EarlyView.
Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring, Enya Abler, Jakub Vavra, Kristina Mayer, Johannes Dorst, Zeynep Elmas, Maximilian Wiesenfarth, Lars Richter, Susanne Petri, Martin Regensburger, Peter Reilich, Bogdan Bjelica, Rea Lumi, Patrick Süß, Hayrettin Tumani, Markus Otto, Jochen H. Weishaupt, Albert C. Ludolph, Patrick Oeckl   +18 more
wiley   +1 more source

Møte i Rådgivende gruppe for BIBSYS-konsortiet 26. mai 2020

, 2020
Møte i Rådgivende gruppe for BIBSYS-konsortiet 26. mai 2020.Møte i Rådgivende gruppe for BIBSYS-konsortiet 26.
Unit
core  

Møte i arbeidsgruppen for Oria 15-02-2021

, 2021
Møte i arbeidsgruppen for Oria 15-02-2021Møte i arbeidsgruppen for Oria 15-02-2021Møte i arbeidsgruppen for Oria 15-02 ...
Unit
core