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Retinal Neurovascular Coupling: From Mechanisms to a Diagnostic Window into Brain Disorders [PDF]

Cells
Retinal neurovascular coupling reflects the precise coordination between neuronal activity, glial support, and vascular responses, mirroring key neurovascular mechanisms in the brain. This review emphasizes the cellular and molecular processes underlying
Wen Shen
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Neurovascular Uncoupling Is Linked to Microcirculatory Dysfunction in Regions Outside the Ischemic Core Following Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Normal brain function depends on the ability of the vasculature to increase blood flow to regions with high metabolic demands. Impaired neurovascular coupling, such as the local hyperemic response to neuronal activity, may contribute to poor ...
Christian Staehr, John T. Giblin, Eugenio Gutiérrez‐Jiménez, Halvor Ø. Guldbrandsen, Jianbo Tang, Shaun L. Sandow, David A. Boas, Vladimir V. Matchkov   +7 more
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Age-Dependent Impairment of Neurovascular and Neurometabolic Coupling in the Hippocampus

Frontiers in Physiology, 2018
Neurovascular and neurometabolic coupling are critical and complex processes underlying brain function. Perturbations in the regulation of these processes are, likely, early dysfunctional alterations in pathological brain aging and age-related ...
Cátia F. Lourenço, Ana Ledo, Miguel Caetano, Rui M. Barbosa, Rui M. Barbosa, João Laranjinha, João Laranjinha   +6 more
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Neurovascular coupling during deep brain stimulation

Brain Stimulation, 2020
Background: Deep brain stimulation (DBS) is an effective treatment for movement disorders, yet its mechanisms of action remain unclear. One method used to study its circuit-wide neuromodulatory effects is functional magnetic resonance imaging (fMRI ...
M. Sohail Noor, Linhui Yu, Kartikeya Murari, Zelma HT. Kiss   +3 more
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Modeling the relationship between neuronal activity and the BOLD signal: contributions from astrocyte calcium dynamics

Scientific Reports, 2023
Functional magnetic resonance imaging relies on the coupling between neuronal and vascular activity, but the mechanisms behind this coupling are still under discussion.
Federico Tesler, Marja-Leena Linne, Alain Destexhe   +2 more
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Lower neurovascular coupling response despite higher cerebral blood flow at rest in apolipoprotein ɛ4 positive adults.

PLoS ONE
Cerebral blood flow at rest declines with age. However, age-related changes in functional measures of cerebrovascular health including cerebrovascular reactivity and neurovascular coupling are not well understood.
Andrew G Pearson, Kathleen B Miller, Adam T Corkery, Nicole A Loggie, Anna J Howery, Leonardo A Rivera-Rivera, Oliver Wieben, Kevin M Johnson, Sterling C Johnson, Jill N Barnes   +9 more
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Neurovascular and Neurometabolic Derailment in Aging and Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2015
The functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation.
Cátia eLourenço, Ana eLedo, Cândida eDias, Rui M Barbosa, João eLaranjinha   +4 more
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The neurovascular basis of processing speed differences in humans: A model-systems approach using multiple sclerosis

NeuroImage, 2020
Behavioral studies investigating fundamental cognitive abilities provide evidence that processing speed accounts for large proportions of performance variability between individuals.
Dinesh K. Sivakolundu, Kathryn L. West, Mark Zuppichini, Monroe P. Turner, Dema Abdelkarim, Yuguang Zhao, Jeffrey S. Spence, Hanzhang Lu, Darin T. Okuda, Bart Rypma   +9 more
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Exploring the translational impact of type 1 diabetes on cerebral neurovascular function through ECoG-LSCI

APL Bioengineering
Type 1 diabetes mellitus (T1DM) can result in complications such as retinopathy, nephropathy, and peripheral neuropathy, which can lead to brain dysfunction.
Shaoyu Yen, Yuhling Wang, Lun-De Liao
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Resting state BOLD-perfusion coupling patterns using multiband multi-echo pseudo-continuous arterial spin label imaging

Scientific Reports
The alteration of neurovascular coupling (NVC), where acute localized blood flow increases following neural activity, plays a key role in several neurovascular processes including aging and neurodegeneration.
Alexander D. Cohen, Stefano Moia, G. Bruce Pike, César Caballero-Gaudes, Yang Wang   +4 more
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