Results 41 to 50 of about 15,500 (253)

Oxygen modulation of neurovascular coupling in the retina [PDF]

Proceedings of the National Academy of Sciences, 2011
Neurovascular coupling is a process through which neuronal activity leads to local increases in blood flow in the central nervous system. In brain slices, 100% O 2 has been shown to alter neurovascular coupling, suppressing activity-dependent vasodilation.
Anusha, Mishra, Arif, Hamid, Eric A, Newman   +2 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Neurovascular coupling in eye-open-eye-close task and resting state: Spectral correspondence between concurrent EEG and fMRI

NeuroImage
Neurovascular coupling serves as an essential neurophysiological mechanism in functional neuroimaging, which is generally presumed to be robust and invariant across different physiological states, encompassing both task engagement and resting state ...
Yi-Chia Kung, Chia-Wei Li, Ai-Ling Hsu, Chi-Yun Liu, Changwei W. Wu, Wei-Chou Chang, Ching-Po Lin   +6 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Structure and function of neurovascular unit in arterial hypertension

Frontiers in Molecular Neuroscience
Arterial hypertension is considered a main risk factor for cognitive impairment and stroke. Although chronic hypertension leads to adaptive changes in the lager cerebral blood vessels which should protect the downstream microvessels, profound changes in ...
Ewa Kozniewska, Marta Aleksandrowicz
doaj   +1 more source

Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease

eLife, 2022
Neurovascular coupling is a critical brain mechanism whereby changes to blood flow accompany localised neural activity. The breakdown of neurovascular coupling is linked to the development and progression of several neurological conditions including ...
Osman Shabir, Ben Pendry, Llywelyn Lee, Beth Eyre, Paul S Sharp, Monica A Rebollar, David Drew, Clare Howarth, Paul R Heath, Stephen B Wharton, Sheila E Francis, Jason Berwick   +11 more
doaj   +1 more source

A 3D Human Neuron‐on‐Chip Platform to Monitor Neuronal Injury Responses

Advanced Healthcare Materials, EarlyView.
This study presents a novel 3D Neuron‐on‐Chip model that can maintain human PSC‐derived excitatory prefrontal cortex neurons in 3D hydrogels and can be used to monitor neuronal injury responses over time. Results show injury‐induced acute neuronal excitotoxicity, declining neuronal connectivity, and the activation of a neurodegenerative, SASP‐like ...
Ruiping Tang, Charles‐Francois Latchoumane, Avi Chopra, Md Marzan Sarkar, Chunki Kim, Nathan Gonsalves, Hsueh‐Fu Wu, John C. Sentmanat, Alan Liu, Isha Mhatre‐Winters, Aditya Mishra, Andrei G. Fedorov, Jay M. Patel, Nadja Zeltner, Steven L. Stice, Jason R. Richardson, Lohitash Karumbaiah   +16 more
wiley   +1 more source

Engineering Nanoplatforms for Alzheimer's Disease Detection via Biomolecular Corona Proteomic and Lipidomic Profiling

Advanced Healthcare Materials, EarlyView.
Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco, Roberto Baretta, Andrea Di Fonzo, Andrea Armirotti, Stefano Cinti, Mara Mirasoli, Marco Frasconi, Claudia Corbo   +7 more
wiley   +1 more source

Evaluation of Cerebral Microvascular Regulatory Mechanisms with Transcranial Doppler in Fabry Disease

Brain Sciences, 2020
Background: Fabry disease (FD) causes cerebrovascular disease (CVD) even if asymptomatic, and this is why it is important to identify non-invasive methods to monitor the disease. We evaluated the usefulness of the cerebral autoregulation, vasoreactivity,
Pedro Castro, Mariana Gutierres, Gilberto Pereira, Susana Ferreira, João Paulo Oliveira, Elsa Azevedo   +5 more
doaj   +1 more source

Loss of Caveolin-1 Impairs Light Flicker-Induced Neurovascular Coupling at the Optic Nerve Head

Frontiers in Neuroscience, 2021
Glaucoma is a neurodegenerative disease, which results in characteristic visual field defects. Intraocular pressure (IOP) remains the main risk factor for this leading cause of blindness. Recent studies suggest that disturbances in neurovascular coupling
Jing Hong Loo, Ying Shi Lee, Chang Yi Woon, Victor H. K. Yong, Bingyao Tan, Bingyao Tan, Bingyao Tan, Leopold Schmetterer, Leopold Schmetterer, Leopold Schmetterer, Leopold Schmetterer, Leopold Schmetterer, Rachel S. Chong, Rachel S. Chong   +13 more
doaj   +1 more source