Results 61 to 70 of about 15,500 (253)

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Modeling the relationship between neuronal activity and the BOLD signal: contributions from astrocyte calcium dynamics

Scientific Reports, 2023
Functional magnetic resonance imaging relies on the coupling between neuronal and vascular activity, but the mechanisms behind this coupling are still under discussion.
Federico Tesler, Marja-Leena Linne, Alain Destexhe   +2 more
doaj   +1 more source

Cortical specificity in neurovascular coupling

Journal of Neurophysiology, 2015
Despite mounting contrary evidence, the metabolic hypothesis is viewed as the predominant theory underlying neurovascular coupling, or the link between neural activity and cerebral blood flow. In a recent study, Huo et al. (Huo BX, Smith JB, Drew PJ.
openaire   +4 more sources

The effect of different anesthetics on neurovascular coupling [PDF]

NeuroImage, 2010
To date, the majority of neurovascular coupling studies focused on the thalamic afferents' activity in layer IV and the corresponding large spiking activity as responsible for functional hyperemia. This paper highlights the role of the secondary and late cortico-cortical transmission in neurovascular coupling. Simultaneous scalp electroencephalography (
Maria Angela Franceschini, Harsha Radhakrishnan, Kiran Thakur, Weicheng Wu, Svetlana Ruvinskaya, Stefan A. Carp, David A. Boas   +6 more
openaire   +2 more sources

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Lower neurovascular coupling response despite higher cerebral blood flow at rest in apolipoprotein ɛ4 positive adults.

PLoS ONE
Cerebral blood flow at rest declines with age. However, age-related changes in functional measures of cerebrovascular health including cerebrovascular reactivity and neurovascular coupling are not well understood.
Andrew G Pearson, Kathleen B Miller, Adam T Corkery, Nicole A Loggie, Anna J Howery, Leonardo A Rivera-Rivera, Oliver Wieben, Kevin M Johnson, Sterling C Johnson, Jill N Barnes   +9 more
doaj   +1 more source

Neurovascular coupling during deep brain stimulation

Brain Stimulation, 2020
Background: Deep brain stimulation (DBS) is an effective treatment for movement disorders, yet its mechanisms of action remain unclear. One method used to study its circuit-wide neuromodulatory effects is functional magnetic resonance imaging (fMRI ...
M. Sohail Noor, Linhui Yu, Kartikeya Murari, Zelma HT. Kiss   +3 more
doaj   +1 more source

Altered neurovascular coupling in neuromyelitis optica [PDF]

Human Brain Mapping, 2018
AbstractNeurovascular coupling reflects the close relationship between neuronal activity and cerebral blood flow (CBF), providing a new mechanistic insight into health and disease. Neuromyelitis optica (NMO) is an autoimmune inflammatory demyelinating disease of the central nervous system and shows cognitive decline‐related brain gray matter ...
Xi Guo, Jiajia Zhu, Ningnannan Zhang, Linjie Zhang, Yuan Qi, Huanhuan Cai, Xue Zhang, Jie Sun, Qiuhui Wang, Li Yang, Fu‐Dong Shi, Chunshui Yu   +11 more
openaire   +2 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Neurovascular and Neurometabolic Derailment in Aging and Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2015
The functional and structural integrity of the brain requires local adjustment of blood flow and regulated delivery of metabolic substrates to meet the metabolic demands imposed by neuronal activation.
Cátia eLourenço, Ana eLedo, Cândida eDias, Rui M Barbosa, João eLaranjinha   +4 more
doaj   +1 more source