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Investigating the Limits of Neurovascular Coupling [PDF]
Neuron, 2016 O'Herron et al. (2016) perform two-photon imaging of vascular and neural responses in cat and rodent primary visual cortex to investigate the limits of neurovascular coupling. Their results suggest important constraints on making inferences about neuronal responses from hemodynamic activity.
George H, Denfield +3 more
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Potassium Channels and Neurovascular Coupling
Circulation Journal, 2010 Neuronal activity is communicated to the cerebral vasculature so that adequate perfusion of brain tissue is maintained at all levels of neuronal metabolism. An increase in neuronal activity is accompanied by vasodilation and an increase in local cerebral blood flow.
Dunn, Kathryn M. +1 more
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Neurovascular coupling in the mammalian brain [PDF]
Experimental Physiology, 2007 Normal brain function requires proper supply of oxygen and glucose in a timely and local manner. This is achieved through an orchestrated intercellular communication between neurones, astrocytes and microvessels that results in a rapid and restricted increase in cerebral blood flow, a process known as neurovascular coupling.
Jessica A, Filosa, Víctor M, Blanco
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Neurovascular dysfunction in vascular dementia, Alzheimer’s and atherosclerosis
BMC Neuroscience, 2018 Efficient blood supply to the brain is of paramount importance to its normal functioning and improper blood flow can result in potentially devastating neurological consequences.
Osman Shabir +2 more
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Altered coupling of resting-state cerebral blood flow and functional connectivity in Meige syndrome
Frontiers in Neuroscience, 2023 IntroductionMeige syndrome (MS) is an adult-onset segmental dystonia disease, mainly manifested as blepharospasm and involuntary movement caused by dystonic dysfunction of the oromandibular muscles.
Aocai Yang +17 more
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The role of nitrite in neurovascular coupling [PDF]
Brain Research, 2011 Nitric oxide (NO), a potent vasodilator and nontraditional neurotransmitter, is an important mediator of the changes in cerebral blood flow (CBF) associated with increased neuronal activity (neurovascular coupling). In the present work, we investigated the role of NO and of its newly recognized precursor, nitrite, in neurovascular coupling using a well-
Barbora, Piknova +3 more
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Mechanisms of neurovascular coupling
Regional blood circulation and microcirculation, 2023 The brain is characterized by a well-developed vascular network and consumes a significant proportion of cardiac output relative to its mass. Normally, the metabolic needs of the brain significantly depend on the intensity of the functioning of its various departments, which requires constant regulation of the level of local blood flow.
A. A. Chervaev +2 more
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Toward three-dimensional in vitro models to study neurovascular unit functions in health and disease
Neural Regeneration Research, 2021 The high metabolic demands of the brain require an efficient vascular system to be coupled with neural activity to supply adequate nutrients and oxygen. This supply is coordinated by the action of neurons, glial and vascular cells, known collectively as ...
Tara M Caffrey +2 more
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Acute resveratrol consumption improves neurovascular coupling capacity in adults with type 2 diabetes mellitus [PDF]
, 2016 Published: 12 July 2016Background: Poor cerebral perfusion may contribute to cognitive impairment in type 2 diabetes mellitus (T2DM). We conducted a randomized controlled trial to test the hypothesis that resveratrol can enhance cerebral vasodilator ...
Daniel Raederstorff +8 more
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Revisiting the role of neurons in neurovascular coupling [PDF]
Frontiers in Neuroenergetics, 2010 In this article, we will review molecular, anatomical, physiological and pharmacological data in an attempt to better understand how excitatory and inhibitory neurons recruited by distinct afferent inputs to the cerebral cortex contribute to the coupled hemodynamic response, and how astrocytes can act as intermediaries to these neuronal populations. We
Cauli, Bruno, Hamel, Edith
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