Results 31 to 40 of about 28,046 (293)

Insulin regulates neurovascular coupling through astrocytes

Proceedings of the National Academy of Sciences, 2022
Mice with insulin receptor (IR)–deficient astrocytes (GFAP-IR knockout [KO] mice) show blunted responses to insulin and reduced brain glucose uptake, whereas IR-deficient astrocytes show disturbed mitochondrial responses to glucose. While exploring the functional impact of disturbed mitochondrial function in astrocytes, we observed that ...
Ana M. Fernandez, Laura Martinez-Rachadell, Marta Navarrete, Julia Pose-Utrilla, Jose Carlos Davila, Jaime Pignatelli, Sonia Diaz-Pacheco, Santiago Guerra-Cantera, Emilia Viedma-Moreno, Rocio Palenzuela, Samuel Ruiz de Martin Esteban, Ricardo Mostany, Cristina Garcia-Caceres, Matthias Tschöp, Teresa Iglesias, Maria L. de Ceballos, Antonia Gutierrez, Ignacio Torres Aleman   +17 more
openaire   +7 more sources

Enhancing human cognition with cocoa flavonoids [PDF]

, 2017
Enhancing cognitive abilities has become a fascinating scientific challenge, recently driven by the interest in preventing age-related cognitive decline and sustaining normal cogni-tive performance in response to cognitively demanding environments.
DE GENNARO, Luigi, Desideri, Giovambattista, Ferrara, Michele, Socci, Valentina, Tempesta, Daniela   +4 more
core   +3 more sources

Potassium Channels and Neurovascular Coupling

Circulation Journal, 2010
Neuronal activity is communicated to the cerebral vasculature so that adequate perfusion of brain tissue is maintained at all levels of neuronal metabolism. An increase in neuronal activity is accompanied by vasodilation and an increase in local cerebral blood flow.
Dunn, Kathryn M., Nelson, Mark T.
openaire   +3 more sources

Macrophages come to mind as keys to cognitive decline [PDF]

, 2016
Cognitive impairment, an underappreciated consequence of hypertension, is linked to cerebral arteriolar disease through poorly defined mechanisms. A study by Faraco et al.
D.G. Harrison, Davies, Faraco, Launer, Liu, Tomasz J. Guzik   +5 more
core   +1 more source

Awake chronic mouse model of targeted pial vessel occlusion via photothrombosis [PDF]

, 2020
Animal models of stroke are used extensively to study the mechanisms involved in the acute and chronic phases of recovery following stroke. A translatable animal model that closely mimics the mechanisms of a human stroke is essential in understanding ...
Boas, David A., Chen, Ichun Anderson, Cheng, Xiaojun, Erdener, Sefik Evren, Kılıç, Kıvılcım, Kura, Sreekanth, Lee, Blaire Ss, Postnov, Dmitry, Sunil, Smrithi, Tang, Jianbo   +9 more
core   +1 more source

Neurovascular coupling in the mammalian brain [PDF]

Experimental Physiology, 2007
Normal brain function requires proper supply of oxygen and glucose in a timely and local manner. This is achieved through an orchestrated intercellular communication between neurones, astrocytes and microvessels that results in a rapid and restricted increase in cerebral blood flow, a process known as neurovascular coupling.
Jessica A, Filosa, Víctor M, Blanco
openaire   +2 more sources

Neurovascular coupling unit dysfunction and dementia: Retinal measurements as tools to move towards population-based evidence

Frontiers in Endocrinology, 2022
Dysfunction of the neurovascular coupling unit may be an important contributor to dementia. The neurovascular coupling unit comprises neuronal structures (e.g. astrocytes) and vascular structures (e.g.
Frank C. T. van der Heide, Frank C. T. van der Heide, Frank C. T. van der Heide, Frank C. T. van der Heide, Thomas T. van Sloten, Thomas T. van Sloten, Nele Willekens, Nele Willekens, Coen D. A. Stehouwer, Coen D. A. Stehouwer   +9 more
doaj   +1 more source

Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7T [PDF]

, 2014
Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their underlying neurovascular origins have recently gained considerable interest.
Aneurin J. Kennerley, Bandettini, Berwick, Blockley, Bohraus, Boorman, Boulant, Buxton, Buxton, Chen, Cohalan, Dimo Ivanov, Donahue, Donahue, Duvernoy, Galassi, Goense, Goense, Goense, Gray, Harald E. Möller, Harel, Hillman, Hua, Huber, Huber, Hurley, Hutchison, Ivanov, Jiang, Jin, Jin, Jochimsen, Jozien Goense, Jöran Lepsien, Keller, Kennerley, Kennerley, Kennerley, Kim, Kim, Kim, Kim, Kim, Kim, Laurentius Huber, Lee, Liu, Logothetis, Logothetis, Lu, Lu, Lu, Mandeville, Martin, Martindale, Moradi, Mullinger, Pasley, Payne, Pfeuffer, Raz, Robert Trampel, Robert Turner, Schridde, Schäfer, Shih, Shin, Shmuel, Shmuel, Smirnakis, Smith, Stefanovic, Stefanovic, Steffen N. Krieger, Tajima, Takano, Turner, Vafaee, Wade, Weber, Wehrli, Wong, Woolsey, Worsley, Xie, Yang, Yaseen, Zappe, Zhao, Zong   +90 more
core   +1 more source

Comparing dynamic causal models of neurovascular coupling with fMRI and EEG/MEG

NeuroImage, 2020
This technical note presents a dynamic causal modelling (DCM) procedure for evaluating different models of neurovascular coupling in the human brain – using combined electromagnetic (M/EEG) and functional magnetic resonance imaging (fMRI) data.
Amirhossein Jafarian, Vladimir Litvak, Hayriye Cagnan, Karl J. Friston, Peter Zeidman   +4 more
doaj   +1 more source

Dynamic Change of Awareness during Meditation Techniques: Neural and Physiological Correlates [PDF]

, 2012
Recent fndings illustrate how changes in consciousness accommodated by neural correlates and plasticity of the brain advance a model of perceptual change as a function of meditative practice.
Barnes, Vernon A., Dillard-Wright, David, Hamilton, Brittany, Jerath, Shivani, Ravinder, Jerath   +4 more
core   +1 more source