Results 111 to 120 of about 4,031,569 (323)

Oxytocin shortens spreading depolarization-induced periorbital allodynia

The Journal of Headache and Pain
Background Migraine is among the most prevalent and burdensome neurological disorders in the United States based on disability-adjusted life years. Cortical spreading depolarization (SD) is the most likely electrophysiological cause of migraine aura and ...
Andrea M. Harriott, Melih Kaya, Cenk Ayata   +2 more
doaj   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

The Neurovascular Unit Dysfunction in the Molecular Mechanisms of Epileptogenesis and Targeted Therapy

Neuroscience Bulletin
Epilepsy is a multifaceted neurological syndrome characterized by recurrent, spontaneous, and synchronous seizures. The pathogenesis of epilepsy, known as epileptogenesis, involves intricate changes in neurons, neuroglia, and endothelium, leading to ...
Xiuxiu Liu, Ying Zhang, Yanming Zhao, Qian Zhang, Feng Han   +4 more
semanticscholar   +1 more source

Oral atogepant mitigates spreading depolarization-induced pain and anxiety behavior in mice

The Journal of Headache and Pain
Background Spreading depolarization (SD) is the most likely cause of migraine aura and may be linked to trigeminal nociception. Using minimally invasive optogenetic SD induction (opto-SD), we previously showed that SD triggers acute periorbital ...
Melih Z. Kaya, Pradeep Banerjee, Cenk Ayata, Andrea M. Harriott   +3 more
doaj   +1 more source

Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1

eLife
Axon guidance molecules are critical for neuronal pathfinding because they regulate directionality and growth pace during nervous system development. However, the molecular mechanisms coordinating proper axonal extension and turning are poorly understood.
Namsuk Kim, Yan Li, Ri Yu, Hyo-Shin Kwon, Anji Song, Mi-Hee Jun, Jin-Young Jeong, Ji Hyun Lee, Hyun-Ho Lim, Mi-Jin Kim, Jung-Woong Kim, Won-Jong Oh   +11 more
doaj   +1 more source

Contralateral dissociation between neural activity and cerebral blood volume during recurrent acute focal neocortical seizures [PDF]

, 2014
OBJECTIVE: Whether epileptic events disrupt normal neurovascular coupling mechanisms locally or remotely is unclear. We sought to investigate neurovascular coupling in an acute model of focal neocortical epilepsy, both within the seizure onset zone and ...
Berwick, J., Boorman, L., Bruyns-Haylett, M., Harris, S., Kennerley, A., Ma, H., Overton, P.G., Schwartz, T.H., Zhao, M.   +8 more
core   +1 more source

Interaction of Microglia and Astrocytes in the Neurovascular Unit

Frontiers in Immunology, 2020
The interaction between microglia and astrocytes significantly influences neuroinflammation. Microglia/astrocytes, part of the neurovascular unit (NVU), are activated by various brain insults.
Lirong Liu, Jia-chen Liu, Jin-shuang Bao, Qinqin Bai, Gai-qing Wang   +4 more
semanticscholar   +1 more source

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Aging Neurovascular Unit and Potential Role of DNA Damage and Repair in Combating Vascular and Neurodegenerative Disorders

Frontiers in Neuroscience, 2019
Progressive neurological deterioration poses enormous burden on the aging population with ischemic stroke and neurodegenerative disease patients, such as Alzheimers’ disease and Parkinson’s disease. The past two decades have witnessed remarkable advances
Yan Li, Lv Xie, Tingting Huang, Yueman Zhang, Jie Zhou, Bo Qi, Xin Wang, Zengai Chen, Peiying Li   +8 more
doaj   +1 more source

Cerebral Aneurysm Occlusion at 12-Month Follow-Up After Flow-Diverter Treatment: Statistical Modeling for V&V With Real-World Data

Frontiers in Medical Technology, 2021
Background: Flow-Diverter (FD) porosity has been pointed as a critical factor in the occlusion of cerebral aneurysms after treatment.Objective: Verification and Validation of computational models in terms of predictive capacity, relating FD porosity and ...
Ana Paula Narata, Laura Obradó, Raquel Kalé Moyano, Juan M. Macho, Jordi Blasco, Antonio López Rueda, Luis San Roman, Sebastian Remollo, Claudia Marinelli, Rosana Cepeda, Héctor Fernández, Ignacio Larrabide, Ignacio Larrabide   +12 more
doaj   +1 more source