Results 111 to 120 of about 2,245,425 (289)

Longitudinal Awake Mouse Brain Imaging Using Functional Ultrasound and Functional Ultrasound Localization Microscopy

Advanced Science, EarlyView.
Awake longitudinal multimodal ultrasound imaging integrates functional ultrasound (fUS), ultrasound localization microscopy (ULM), and functional ULM (fULM) to characterize cerebrovascular function, microvascular architecture, and flow dynamics within the same animals over time.
Zhe Huang, Yike Wang, Matthew R. Lowerison, Yue Xu, Murong Yi, Bing‐Ze Lin, YiRang Shin, Nathiya Vaithiyalingam Chandra Sekaran, Daniel A. Llano, Pengfei Song   +9 more
wiley   +1 more source

Schematic diagram of morroniside on neurovascular homeostasis rehabilitation (NHR) hypothesis.

, 2014
This diagram presents a new model proposed for restoration of microvessel integrity of neurovascular unit following ischemia. Cerebral ischemia induces not only initial injury on the vascular compartments of the neurovascular unit, but also the ...
Hua Cheng (317084), Lei Li (29537), Xiao-Min Wang (282685), Xun-Ming Ji (590419), Jing-dong Xu (590418), Fang-Ling Sun (590415), Hou-Xi Ai (590417), Xiao-feng Wang (5652343), Wen Wang (6570), Ying Wang (11406), Li Zhang (8200), Jin-Long Xue (590416)   +11 more
core   +1 more source

Selective regulation of corticostriatal synapses by astrocytic phagocytosis

Nature Communications
In the adult brain, neural circuit homeostasis depends on the constant turnover of synapses via astrocytic phagocytosis mechanisms. However, it remains unclear whether this process occurs in a circuit-specific manner.
Ji-young Kim, Hyeyeon Kim, Won-Suk Chung, Hyungju Park   +3 more
doaj   +1 more source

Chronic Kidney Disease and Cerebrovascular Pathology: Incidence and Functional Outcomes in Riga East University Hospital

Medicina
Background and Objectives: The aim of this study was to investigate the incidence of cerebrovascular pathology in patients with chronic kidney disease and its effect on functional outcomes. Materials and Methods: In a retrospective cross-sectional study (
Violeta Zubkova, Aleksejs Ševčenko, Igors Miļuhins, Ilga Ķikule, Iveta Haritončenko, Guntis Karelis   +5 more
doaj   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Spatial and temporal recruitment of the neurovascular unit during development of the mouse blood-retinal barrier [PDF]

, 2018
The inner blood-retinal barrier (BRB) is made up by the neurovascular unit, consisting of endothelial cells, pericytes and glial cells. The BRB maintains homeostasis of the neural retina, but in pathological eye conditions the neurovascular unit is often
Noorden, Cornelis J. F. van, Ilse M.C. Vogels, Vogels, IMC, van Veen, H.A., Schlingemann, Reinier O., Reinier O. Schlingemann, Schlingemann, R.O., Cornelis J.F. van Noorden, Wijk, Anne-Eva van der, Ingeborg Klaassen, Henk A. van Veen, van der Wijk, A.E., Klaassen, Ingeborg, Veen, Henk A. van, Klaassen, I., Anne-Eva van der Wijk, van Noorden, CJF, Vogels, Ilse M.C., Vogels IMC, van Veen HA, Klaassen I, van Noorden CJF, van der Wijk AE, Schlingemann RO   +23 more
core   +1 more source

A Neutrophil Membrane‐Encapsulated Pd/hCeO2 Nanoformulation for Alleviating Age‐Dependent Perioperative Neurocognitive Disorders

Advanced Science, EarlyView.
This study reports a neutrophil membrane‐encapsulated Pd/hCeO2 nanozyme (PCN) for targeted treatment of perioperative neurocognitive disorders (PND) in aged mice. PCN inhibits glycolysis‐driven microglial activation and neuroinflammation, improves mitochondrial respiration, and maintains blood‐brain barrier integrity and synaptic function, ultimately ...
Lili Huang, Jiahui Cheng, Huan Xu, Qiang Zhang, Xiao Zhang, Ye Liu, Yizhe Zhang, Wanbing Dai, Zhi Xiong, Linghuan Guo, Lingling Xu, Wen Wang, Xin Xu, Yan Zhou, Weifeng Yu, Bo Li, Diansan Su, Daxiang Wen   +17 more
wiley   +1 more source

Acoplamento neurovascular e neuroimagem funcional em epilepsia [PDF]

, 2009
INTRODUCTION: The neural regulation of the microcirculation is done by the functional neurovascular unit that is composed of vascular, astroglial and neuronal cells.
Wichert-Ana,Lauro, ABUD, Daniel Giansante, Leite,João Pereira, ROMCY-PEREIRA, Rodrigo, Daniel Giansante Abud, BECKER JUNIOR, Valesio, Silva,Rhelen Piantino Leitão Ferreira da, WICHERT-ANA, Lauro, Becker Junior,Valesio, Rhelen Piantino Leitão Ferreira da Silva, Sara Escorsi-Rosset, João Pereira Leite, Abud,Daniel Giansante, Romcy-Pereira,Rodrigo, Escorsi-Rosset,Sara, Rodrigo Romcy-Pereira, ESCORSI-ROSSET, Sara, Lauro Wichert-Ana, Valesio Becker Junior, LEITE, João Pereira, SILVA, Rhelen Piantino Leitão Ferreira da   +20 more
core   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source