Results 81 to 90 of about 4,031,569 (323)
Pericytes of the neurovascular unit: key functions and signaling pathways
Nature Neuroscience, 2016 Melanie D. Sweeney +2 more
semanticscholar +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto +12 more
wiley +1 more source
TWEAK and Fn14 in the Neurovascular Unit [PDF]
Frontiers in Immunology, 2013 The neurovascular unit (NVU) is a dynamic structure assembled by endothelial cells (EC), a basement membrane (BM), perivascular astrocytes (PA), pericytes, and surrounding neurons. The NVU regulates the passage of substances and cellular elements from the intravascular space into the brain parenchyma.
openaire +3 more sources
Cerebral Circulation - Cognition and BehaviorHighlights • Meta-analysis results of cerebrospinal fluid/serum albumin quotient (Q-Alb) revealed disruption of the neurovascular unit with the ability to differentiate VCD patients from healthy controls.• Biomarkers of endothelial dysfunction (VEGF ...
G. Hansra +9 more
semanticscholar +1 more source
Rhythms in barriers and fluids: Circadian clock regulation in the aging neurovascular unit.
Neurobiology of Disease, 2023 The neurovascular unit is where two very distinct physiological systems meet: The central nervous system (CNS) and the blood. The permeability of the barriers separating these systems is regulated by time, including both the 24 h circadian clock and the ...
Lea Skapetze +5 more
semanticscholar +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos +9 more
wiley +1 more source
The Translational Significance of the Neurovascular Unit [PDF]
Journal of Biological Chemistry, 2017 The mammalian brain is supplied with blood by specialized vasculature that is structurally and functionally distinct from that of the periphery. A defining feature of this vasculature is a physical blood-brain barrier (BBB). The BBB separates blood components from the brain microenvironment, regulating the entry and exit of ions, nutrients ...
Heather L, McConnell +3 more
openaire +2 more sources
Elevated plasma levels of alpha-synuclein are dispensable for Parkinson’s disease pathology
npj Parkinson's DiseaseAlthough α-synuclein levels are elevated in the blood plasma of Parkinson’s disease (PD) patients, it remains unclear whether blood-derived α-synuclein directly contributes to PD.
Jin-Young Jeong +5 more
doaj +1 more source
Brain, Behavior, & Immunity - Health, 2023 The neurovascular unit, comprised of vascular cell types that collectively regulate cerebral blood flow to meet the needs of coupled neurons, is paramount for the proper function of the central nervous system. The neurovascular unit gatekeeps blood-brain
Marina Wakid +11 more
doaj +1 more source
Structure Learning in Coupled Dynamical Systems and Dynamic Causal Modelling [PDF]
, 2019 Identifying a coupled dynamical system out of many plausible candidates, each of which could serve as the underlying generator of some observed measurements, is a profoundly ill posed problem that commonly arises when modelling real world phenomena.
Friston, Karl +3 more
core +1 more source