Results 81 to 90 of about 34,675 (249)

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Correction: Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine

The Journal of Headache and Pain, 2023
Rosaria Greco, Miriam Francavilla, Chiara Demartini, Anna Maria Zanaboni, Mikael H. Sodergren, Sara Facchetti, Barbara Pacchetti, Michela Palmisani, Valentina Franco, Cristina Tassorelli   +9 more
doaj   +1 more source

Is canonical SD a clinically relevant model of migraine? Argument pro

The Journal of Headache and Pain
Migraine with aura is a phenotypically heterogeneous disorder characterized by scintillating scotoma, sensory, language, and/or motor disturbance often followed by a severe headache, and cutaneous allodynia.
Muhammed Miran Oncel, Andrea M. Harriott
doaj   +1 more source

Neurovascular Unit in Chronic Pain

Mediators of Inflammation, 2013
Chronic pain is a debilitating condition with major socioeconomic impact, whose neurobiological basis is still not clear. An involvement of the neurovascular unit (NVU) has been recently proposed.
Beatrice Mihaela Radu, Placido Bramanti, Francesco Osculati, Maria-Luisa Flonta, Mihai Radu, Giuseppe Bertini, Paolo Francesco Fabene   +6 more
doaj   +1 more source

Spatial and temporal recruitment of the neurovascular unit during development of the mouse blood-retinal barrier

, 2018
The inner blood-retinal barrier (BRB) is made up by the neurovascular unit, consisting of endothelial cells, pericytes and glial cells. The BRB maintains homeostasis of the neural retina, but in pathological eye conditions the neurovascular unit is often
Vogels, Ilse M. C., van Noorden, Cornelis J. F., Noorden, Cornelis J. F. van, Ilse M.C. Vogels, Vogels, IMC, van Veen, H.A., Schlingemann, Reinier O., van der Wijk, Anne-Eva, Reinier O. Schlingemann, Schlingemann, R.O., Cornelis J.F. van Noorden, Wijk, Anne-Eva van der, Ingeborg Klaassen, Henk A. van Veen, van der Wijk, A.E., Klaassen, Ingeborg, Veen, Henk A. van, Klaassen, I., Anne-Eva van der Wijk, van Noorden, CJF, van Veen, Henk A., Vogels, Ilse M.C.   +21 more
core   +1 more source

Microfluidic models of the neurovascular unit [PDF]

, 2021
Need for novel models of the NVU Chapter 1, the general introduction, describes the need for novel in vitro models of the human brain and its vasculature.
Wevers, Nienke Richelle
core  

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Occult cerebrovascular disease and late-onset epilepsy: Could loss of neurovascular unit integrity be a viable model? [PDF]

, 2011
Late-onset epilepsy (LOE) first occurs after 60 years of age and may be due to occult cerebrovascular disease (CVD) which confers an increased risk of stroke.
Allan, Stuart M.; id_orcid, Parkes, Laura M.; id_orcid, Hedley C. A. Emsley, Parkes, Laura M., Lorna M. Gibson, Emsley, Hedley C. A., Allan, Stuart M., Laura M. Parkes, Gibson, Lorna M., Emsley, Hedley C A, Stuart M. Allan   +10 more
core   +1 more source