Results 61 to 70 of about 4,031,569 (323)

Matrix metalloproteinases at key junctions in the pathomechanism of stroke [PDF]

, 2011
Matrix metalloproteinases play a crucial role in the remodelling of the extracellular matrix through direct degradation of its structural proteins and control of extracellular signaling.
Amento, Ang, Asahi, Asahi, Barkho, Bergers, Bini, Cao, Cardone, Chinopoulos, Cunningham, Denker, Dong, Fabunmi, Fisher, Frisch, Galis, Galis, Galis, Galis, Gidday, Godin, Gross, Gu, Gu, Gurney, Haas, Haddad, Halliwell, Hamann, Harkness, Herman, Hornig, Hyslop, Itoh, Kumura, Langton, Lapchak, Larsen, Lee, Lelongt, Loftus, Lucivero, Luttun, McQuibban, Meredith, Montaner, Montaner, Nagase, Nagel, Nagy, Nagy, Nikkari, Pagenstecher, Qi, Rajagopalan, Ramos, Rekhter, Rolfe, Romanic, Rosell, Rosenberg, Rosenberg, Rosenberg, Rosenberg, Sarén, Sato, Seo, Shrivastava, Shubayev, Siao, Sole, Sottrup, Sternlicht, Strongin, Sukhova, Suzuki, Suzuki, Svedin, Tsuji, Turner, Van, Vogel, Wang, Wang, Webersinke, Yepes, Ying, Zhang, Zhang, Zhang, Zhao   +91 more
core   +1 more source

Lifelong exposure to high‐altitude hypoxia in humans is associated with improved redox homeostasis and structural–functional adaptations of the neurovascular unit

Journal of Physiology, 2023
High‐altitude (HA) hypoxia may alter the structural–functional integrity of the neurovascular unit (NVU). Herein, we compared male lowlanders (n = 9) at sea level (SL) and after 14 days acclimatization to 4300 m (chronic HA) in Cerro de Pasco (CdP), Péru
B. Stacey, R. Hoiland, H. Caldwell, C. Howe, Tyler D. Vermeulen, M. Tymko, G. Vizcardo-Galindo, D. Bermudez, Rómulo J Figueroa-Mujíica, Christopher Gasho, E. Tuaillon, C. Hirtz, S. Lehmann, Nicola Marchi, Hayato Tsukamoto, F. Villafuerte, P. Ainslie, D. Bailey   +17 more
semanticscholar   +1 more source

Making Connexons in the Neurovascular Unit [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2012
Less than a decade ago, the term blood–brain barrier underwent a major conceptual change when it was recognized that the cerebrovasculature was anything, but passive in its structure and function. Instead of a layer of bricks separated by heavy mortar, the brain endothelial cell became one of a complement of cell types performing together as a dynamic,
openaire   +2 more sources

Pericyte Signaling in the Neurovascular Unit [PDF]

Stroke, 2009
Brain pericytes are intimately associated with capillary endothelial cells, separated only by basement membrane. Pericyte research has been hampered by absence of pericyte-specific immunochemical markers. The vast array of pericyte functions include contractility, immunologic, migratory, and angiogenic. Pericytes have stem cell potential, contribute to
openaire   +2 more sources

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017. [PDF]

, 2017
This is a report on the CNS barrier congress held in London, UK, March 22-23rd 2017 and sponsored by Kisaco Research Ltd. The two 1-day sessions were chaired by John Greenwood and Margareta Hammarlund-Udenaes, respectively, and each session ended with a ...
A Brenn, A Reijerkerk, B Zhang, C Cerutti, DA Ridder, EJ Duh, ES Lippmann, GK Dogbevia, HC Helms, HC Helms, I Loryan, I Loryan, J Greenwood, J Keaney, J Korbelin, JA Ford, M Brkic, M Campbell, M Campbell, MA Lopez-Ramirez, O Huber, P Canning, R Martinelli, RE Vandenbroucke, S Balusu, S Dragoni, Y Hu, Y Molino, YH Chen   +28 more
core   +9 more sources

A Systems Thinking Approach to Redesigning the Patient Experience to Reduce 30 Day Hospital Readmission [PDF]

, 2018
INTRODUCTION The cost of medical care is spiraling out of control, and one of the many reasons is lack of preventative care, poor communication to the patient and primary caregiver(s) both in an inpatient and outpatient setting.
DePrince, RN, BA, CCRN, SCRN, Maureen, Flounders, MBA, William, Gates, MBA, Justin, Heffner, MBA, Steven, Lawler, BS, RN, MSN, FNP-BC, MBA, Michael, Pardini, MBA, Julia, Rosenwasser, MD, MBA, FACS, FAHA, Robert H.   +6 more
core   +2 more sources

Contributions of blood–brain barrier imaging to neurovascular unit pathophysiology of Alzheimer’s disease and related dementias

Frontiers in Aging Neuroscience, 2023
The blood–brain barrier (BBB) plays important roles in the maintenance of brain homeostasis. Its main role includes three kinds of functions: (1) to protect the central nervous system from blood-borne toxins and pathogens; (2) to regulate the exchange of
Yuto Uchida, H. Kan, K. Sakurai, K. Oishi, N. Matsukawa   +4 more
semanticscholar   +1 more source

Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment.

Neurobiology of Disease, 2022
Cerebral small vessel disease (CSVD) is a generic term used for intracranial vascular disorders caused by the structural changes of cerebral microvessels, including the small arteries, arterioles, capillaries and venules.
Qin Yang, Xiaobo Wei, Bin Deng, Zihan Chang, Dana Jin, Yonghua Huang, John H. Zhang, M. Yenari, Kunling Jin, Qing Wang   +9 more
semanticscholar   +1 more source

Vasculo-Neuronal Coupling and Neurovascular Coupling at the Neurovascular Unit: Impact of Hypertension [PDF]

Frontiers in Physiology, 2020
Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates cerebral blood flow and maintain brain homeostasis. Here, we describe evidence for cells of the NVU contributing to critical physiological processes such as cerebral autoregulation, neurovascular coupling, and vasculo-neuronal coupling.
Jessica L. Presa, Jessica L. Presa, Flavia Saravia, Zsolt Bagi, Jessica A. Filosa   +4 more
openaire   +4 more sources

Neuroprotection targeting protein misfolding on chronic cerebral hypoperfusion in the context of metabolic syndrome [PDF]

, 2018
Metabolic syndrome (MetS) is a cluster of risk factors that lead to microvascular dysfunction and chronic cerebral hypoperfusion (CCH). Long-standing reduction in oxygen and energy supply leads to brain hypoxia and protein misfolding, thereby linking CCH
Capani, Francisco, Herrera, María Inés, Kusnier, Carlos Federico, Luaces, Juan Pablo, Otero-Losada, Matilde Estela, Toro Urrego, Nicolás, Udovin, Lucas   +6 more
core   +1 more source