Results 161 to 170 of about 4,031,569 (323)

Blood Lactate as a Prognostic Biomarker for Survival and Weight Loss in Amyotrophic Lateral Sclerosis: An Exploratory–Validation Study

Annals of Neurology, EarlyView.
Objective Lactate is increasingly recognized as an energy substrate, but its relevance to amyotrophic lateral sclerosis (ALS) remains unclear. We examined whether blood lactate is associated with survival and weight loss in ALS. Methods This retrospective study included an Australian exploratory cohort and a Japanese validation cohort with clinical ...
Ryutaro Nakamura, Frederik J. Steyn, Shuhei Kobashi, Nobuhiro Ogawa, Akihiro Kitamura, Isamu Yamakawa, Robert D. Henderson, Shyuan T. Ngo, Makoto Urushitani   +8 more
wiley   +1 more source

Cryo-EM structures of mouse bestrophin 1 channel in closed and partially open conformations

Molecules and Cells
: Bestrophin 1 (BEST1) channels are calcium-activated Cl− channels involved in diverse physiological processes, including gliotransmitter release in astrocytes.
Kwon-Woo Kim, Euna Lee, Ara Ko, Junmo Hwang, Kunwoong Park, Byoung-Cheol Lee, Ki Woo Kim, Won-Jong Oh, Kyuhyung Kim, Hyun-Ho Lim   +9 more
doaj   +1 more source

Design of Force Meter for Traction Unit [PDF]

, 2019
Force gauge is an instrument used to measure the force on the traction unit. The purpose of this study is made a force gauge meter which used during traction operation. The main component of this force gauge meter is Atmega 328, HX711 module and Loadcell
Aprilyana, G. (Gita), Setioningsih, E. D. (Endang), Triwiyanto, T. (Triwiyanto)   +2 more
core  

Through Skull Fluorescence Imaging of the Brain in a New Near-Infrared Window

, 2014
To date, brain imaging has largely relied on X-ray computed tomography and magnetic resonance angiography with limited spatial resolution and long scanning times.
Andreasson, Katrin I., Antaris, Alexander L., Atochin, Dmitriy N., Chang, Junlei, Chen, Changxin, Dai, Hongjie, Diao, Shuo, Hong, Guosong, Huang, Paul L., Kuo, Calvin J., Zhang, Bo, Zhao, Su   +11 more
core   +2 more sources

High Prevalence of SOD1 Pathogenic Variants in the UK Biobank: Implications for Early Intervention in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective SOD1 is the second most frequently mutated gene in European patients with amyotrophic lateral sclerosis (ALS). Given the recent authorization of SOD1‐targeted antisense oligonucleotides for SOD1‐ALS, prompt screening for SOD1 mutations in patients with ALS patients is highly recommended.
Delia Gagliardi, Chiara Villella, Matteo Zanovello, Virginia Iacobelli, Stefania Corti, Giacomo Pietro Comi, Pietro Fratta, Henry Houlden, Arianna Tucci, Dario Ronchi   +9 more
wiley   +1 more source

Novel Monoclonal Antibody Detects Small Aβ Oligomers More Sensitively Than Lecanemab in Alzheimer's Disease CSF, Serum and Culture Media

Annals of Neurology, EarlyView.
Objective Aqueously diffusible oligomers of the amyloid β‐protein (oAβ) are neurotoxic and play a role in neuronal dysfunction in Alzheimer's disease (AD). Accurate quantification of oAβ in brains and biofluids could be valuable for understanding and monitoring AD.
Yi Ran Xu, Youqi Tao, Alexandra M. Lish, Shaomin Li, Beth L. Ostaszewski, Amirah K. Anderson, Tracy Young‐Pearse, Trebor L. Lawton, Hyun‐Sik Yang, Dominic M. Walsh, Ting Yang, Dennis J. Selkoe   +11 more
wiley   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, EarlyView.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

SEMA3E-PLEXIN-D1 AXON GUIDANCE SIGNALING ENHANCES MTSS1 EXPRESSION TO REGULATE PROPER STRIATONIGRAL PROJECTION

IBRO Neuroscience Reports, 2023
Won-Jong Oh, Yan Li, Namsuk Kim
doaj   +1 more source

Statistical analysis plan for the multicenter, open, randomized controlled clinical trial to assess the efficacy and safety of intravenous tirofiban vs aspirin in acute ischemic stroke due to tandem lesion, undergoing recanalization therapy by endovascular treatment (ATILA trial)

Trials
Rationale In-stent reocclusion after endovascular therapy has a negative impact on outcomes in acute ischemic stroke (AIS) due to tandem lesions (TL).
Elena Zapata-Arriaza, Manuel Medina-Rodríguez, Francisco Moniche Álvarez, Asier de Albóniga-Chindurza, Marta Aguilar-Pérez, Leire Ainz-Gómez, Pablo Baena-Palomino, Aynara Zamora, Blanca Pardo-Galiana, Fernando Delgado-Acosta, Roberto Valverde Moyano, Elvira Jiménez-Gómez, Isabel Bravo Rey, Rafael Oteros Fernández, Irene Escudero-Martínez, Isabel Vielba-Gomez, Lluis Morales Caba, Jose Díaz Pérez, Estefania García Molina, Sonia Mosteiro, María del Mar Castellanos Rodrigo, Laura Amaya Pascasio, Carlos Hidalgo, María del Mar Freijo Guerrero, Eva González Díaz, Jose María Ramírez Moreno, Luis Fernández Prudencio, Mikel Terceño Izaga, Saima Bashir Viturro, Miguel Ángel Gamero-García, Silvia Jiménez Jorge, Clara Rosso Fernández, Joan Montaner, Alejandro González García   +33 more
doaj   +1 more source

Patient-reported symptoms and admission pathways in stroke mimics versus confirmed stroke or transient ischaemic attack: a cross-sectional observational study

BMJ Open
Objectives To determine patient-reported symptoms and clinical factors associated with mimics and differences in health-seeking behaviour versus stroke.Design This is a post-hoc analysis of a cross-sectional survey of interviews on patient-reported ...
Jawad Haider Butt, Christina Kruuse, Heidi Shil Eddelien, Viktor Frederik Idin Sørensen   +3 more
doaj   +1 more source