A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders
Abstract Background Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood‐onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult‐derived paradigms. Objective To identify key gaps in the current use of DBS in childhood‐onset movement disorders and to ...
Daniela Munoz‐Chesta +6 more
wiley +1 more source
Macrophages and endothelial cells in the neurovascular unit
Jan Wenzel, Markus Schwaninger
openaire +2 more sources
Does Neuroglobin Protect Against Stroke? Insights Into the Role of Neurovascular Unit Cells. [PDF]
Peinado MÁ +8 more
europepmc +1 more source
Challenges of Pain in Parkinson's Disease: Results from the OCEAN Study
Abstract Background Pain is a common non‐motor symptom in Parkinson’s disease (PD) and is often associated to fluctuations. Objective The OpiCapone Effect on motor fluctuations and pAiN (OCEAN) study evaluated the effect of opicapone on fluctuation‐related pain when added to levodopa therapy in PD patients.
Kallol Ray Chaudhuri +13 more
wiley +1 more source
Cell- and sex-specificity in the transcriptomic response of the hippocampal neurovascular unit to obesity. [PDF]
Norman JE +3 more
europepmc +1 more source
Abstract Background Plasma phosphorylated‐tau at threonine‐217 (p‐tau217) and threonine‐181 (p‐tau181) are scalable, minimally invasive biomarkers of Alzheimer's disease (AD) pathology. In Parkinson's disease (PD), AD co‐pathology may contribute to its clinical heterogeneity.
Eleonora Fiorenzato +16 more
wiley +1 more source
The Role of miRNAs in Regulating Neurovascular Unit Homeostasis: Bidirectional Communication and Therapeutic Insights in Ischemic Stroke. [PDF]
Chen H, Gao T, Ma F, Jia Z.
europepmc +1 more source
Kinematic Features of Voluntary and Involuntary Head Movements in Cervical Dystonia
Abstract Background Cervical dystonia (CD) has a varied motor presentation, combining abnormal postures with complex involuntary head movements. Classification of these motor patterns remains imprecise, relying on descriptive terminology without robust definitions. Objectives To provide a kinematically‐grounded description of the motor phenomenology of
Thomas Hart +6 more
wiley +1 more source
Role of NADPH Oxidases as Novel Therapeutic Targets for the Impaired Neurovascular Unit in the Early Stage of Diabetic Retinopathy. [PDF]
Dionysopoulou S, Thermos K.
europepmc +1 more source
Abstract Background Long‐read sequencing and multi‐omic analytical frameworks are increasingly being adopted in rare disease diagnostics. However, clinical workflows comprehensively integrating these methodologies remain uncommon. Objective This study aimed to assess the potential and limitations of integrating long‐read genomic, transcriptomic, and ...
Ugo Sorrentino +23 more
wiley +1 more source

