Results 171 to 180 of about 154,916 (330)

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Ultra-high-brightness and tuneable attosecond-long electron beams with the laser wake field acceleration. [PDF]

Sci Rep
Tomassini P, Avella F, Hafz NAM, Labate L, Horný V, Tóth S, Doria D, Gizzi LA.   +7 more
europepmc   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Room-temperature ultrasensitive photon-level detection in the subterahertz frequency regime. [PDF]

Sci Rep
Notake T, Nawata K, Takida Y, Yadav D, Minamide H.   +4 more
europepmc   +1 more source

Considerations for the development of neutral beam injection for fusion reactors or DEMO

, 2017
R. Hemsworth, D. Boilson
semanticscholar   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Room-temperature high-efficiency spin injection via van der Waals tunnel contact. [PDF]

Nat Commun
Huang S, Hou F, Qu T, Zhu L, Wang Z, Zhang B, Wang B, Wang C, Yuan G, Chang X, Özyilmaz B, Huang H, Zhang F, Gao L, Lin J, Fu D, Zhang R.   +16 more
europepmc   +1 more source

Calculation of prompt loss and toroidal field ripple loss under neutral beam injection on EAST

, 2017
Bin Wu, B. Hao, R. White, Jinfang Wang, Qing Zang, Xiaofeng Han, Chundong Hu   +6 more
semanticscholar   +1 more source

Rigid Hollow Microparticles for Enhanced Focused Ultrasound Treatment Under Optoacoustic Guidance

Advanced Science, EarlyView.
By combining focused ultrasound (FUS) and acoustically active hollow borosilicate microparticles (HBMPs), we demonstrate tunable control over interparticle dynamics and their localized thermal energy deposition. Modulation of acoustic frequency and particle concentration tailors the energy delivery, allowing adaptive, material‐based regulation of ...
Nima Mahkam, Yi Chen, Héctor Estrada, Ananya Amitabh, Amirreza Aghakhani, Metin Sitti, Daniel Razansky   +6 more
wiley   +1 more source

Disaster-causing mechanism and control technology of interlayer rock breakage in gently inclined close distance coal seams mining. [PDF]

Sci Rep
Yuchi X, Du X, Shu P, Yu L, Lei W, Yang W, Zhang Z.   +6 more
europepmc   +1 more source