Results 51 to 60 of about 26,297 (256)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Approximate Controllability of Higher-Order Hilfer Fractional Neutral Stochastic Systems Driven by Fractional Brownian Motion, Poisson Jumps, and Non-Instantaneous Impulses

Fractal and Fractional
This paper addresses the existence of mild solutions and the approximate controllability of a class of higher-order Hilfer fractional semi-linear neutral stochastic differential equations with non-instantaneous impulses in Hilbert spaces.
A. M. Sayed Ahmed, Taha Radwan, M. Elsaid Ramadan, Hamdy M. Ahmed   +3 more
doaj   +1 more source

LMI-Based Delayed Output Feedback Controller Design for a Class of Fractional-Order Neutral-Type Delay Systems Using Guaranteed Cost Control Approach

Entropy, 2022
In this research work, we deal with the stabilization of uncertain fractional-order neutral systems with delayed input. To tackle this problem, the guaranteed cost control method is considered.
Zahra Sadat Aghayan, Alireza Alfi, António M. Lopes   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Controllability for a new class of fractional neutral integro-differential evolution equations with infinite delay and nonlocal conditions

Advances in Difference Equations, 2017
In this paper, we apply the fractional calculus and a suitable fixed point theorem with the measure of noncompactness to give the sufficient conditions of the controllability for a new class of fractional neutral integro-differential evolution systems ...
Jun Du, Wei Jiang, Denghao Pang, Azmat Ullah Khan Niazi   +3 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Laser Powder Bed Fusion of Alumina: Effects of Scanning Strategies on External and Internal Defects

Advanced Engineering Materials, EarlyView.
This study investigates how scanning strategies affect pure alumina in laser powder bed fusion. Linear 45° scanning yields uniform surfaces but high porosity, while the island‐concentric strategy provides higher density with through‐holes favorable for infiltration. Findings highlight pathways toward optimizing defect‐free alumina parts.
Mohamed Abdelmoula, Gökhan Küçüktürk, Duran Kaya, David Grossin, Christophe Tenailleau, Benjamin Duployer, Enrique Juste, Fabrice Petit   +7 more
wiley   +1 more source

Fundamental Matrix, Integral Representation and Stability Analysis of the Solutions of Neutral Fractional Systems with Derivatives in the Riemann—Liouville Sense

Fractal and Fractional
The paper studies a class of nonlinear disturbed neutral linear fractional systems with derivatives in the the Riemann–Liouville sense and distributed delays.
Hristo Kiskinov, Mariyan Milev, Slav Ivanov Cholakov, Andrey Zahariev   +3 more
doaj   +1 more source

Innovative Processing of Compacted Waste Aluminum Alloy Powders via Controlled Remelting and Solidification

Advanced Engineering Materials, EarlyView.
This study demonstrates an efficient recycling route for out‐of‐spec AlSi10Mg atomized powders through compaction and arc remelting followed by suction casting. By correlating compaction load, cooling rate, and resulting microstructure, we show that intermediate pressures (50–80 kN) and rapid cooling refine dendrites, reduce porosity, and enhance ...
Mila Christy de Oliveira, Marcella Gaute Cavalcante Xavier, Abdoul‐Aziz Bogno, Piter Gargarella, José Eduardo Spinelli   +4 more
wiley   +1 more source

Evaluating Energy Absorption Performance of Filled Lattice Structures

Advanced Engineering Materials, EarlyView.
Maximum stress must be considered to robustly evaluate energy absorber designs. This approach was applied to compare all types of absorbers in a single Ashby diagram and determine the utility of filling lattice voids with a second material. High‐performance fillers can improve the performance of lattices that are limited by buckling or catastrophic ...
Christian Bonney, William P. King, Iwona Jasiuk   +2 more
wiley   +1 more source