Results 51 to 60 of about 983,838 (268)

Oscillation of differential systems of neutral type [PDF]

open access: yesCzechoslovak Mathematical Journal, 2005
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Next-generation light-emitting devices combining organic emitters and halide perovskites

open access: yesApplied Physics Express
Organic-perovskite hybrid light-emitting devices combine the superior emissive properties of organic fluorophores with the high carrier mobility and structural versatility of halide perovskites.
Toshinori Matsushima
doaj   +1 more source

Dichotomy Condition and Periodic Solutions for Two Nonlinear Neutral Systems

open access: yesJournal of Function Spaces, 2022
In this article, we consider two nonlinear neutral systems with multiple delays. Our main tool here is to use dichotomy theory to construct an implicit solution for these two systems.
Mouataz Billah Mesmouli   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Upcycling poly(succinates) with amines to N-substituted succinimides over succinimide anion-based ionic liquids

open access: yesNature Communications
The chemical transformation of waste polymers into value-added chemicals is of significance for circular economy and sustainable development. Herein, we report upcycling poly(succinates) (PSS) with amines into N-substituted succinimides over succinimide ...
Fengtian Wu   +12 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Finite-Time Stability of Neutral Fractional Time-Delay Systems via Generalized Gronwalls Inequality

open access: yesAbstract and Applied Analysis, 2014
This paper studies the finite-time stability of neutral fractional time-delay systems. With the generalized Gronwall inequality, sufficient conditions of the finite-time stability are obtained for the particular class of neutral fractional time-delay ...
Pang Denghao, Jiang Wei
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy