Results 91 to 100 of about 565,325 (396)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Public Opinion as an Instrument of Socio-Cultural Influence in the Debate on the «NATO Option» in Finland

open access: yesКонцепт: философия, религия, культура, 2020
The article analyzes how the attitude of the Finnish population to Finland’s policy of military non-alignment correlates with the official foreign strategy.
N. Yu. Vezhlivtseva
doaj   +1 more source

Dirac-point photocurrents due to photothermoelectric effect in non-uniform graphene devices

open access: yes, 2019
Q. Ma et al.[1] recently reported a strong photocurrent associated with charge neutrality in graphene devices with non-uniform geometries, which they interpreted as an intrinsic photoresponse enhanced by the momentum non-relaxing nature of electron ...
Fuhrer, Michael S., Medhekar, Nikhil V.
core   +1 more source

Thermodynamic Prediction of Protein Neutrality [PDF]

open access: yes, 2004
We present a simple theory that uses thermodynamic parameters to predict the probability that a protein retains the wildtype structure after one or more random amino acid substitutions.
Anfinsen   +32 more
core   +2 more sources

Neutrality

open access: yes, 2014
During the 19th century, neutrality evolved into a set of legal and political tools designed to limit the impact of wars on the international system. This form of neutrality did not survive the first “total war”; remaining neutral was still possible, but only in closely circumscribed conditions.
openaire   +5 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Neutralność światopoglądowa

open access: yesAnaliza i Egzystencja, 2016
In this paper I focus on the concept of neutrality taken in the meaning typical for political discussions concerning e.g. the religious neutrality of the state.
Arkadiusz Chrudzimski
doaj   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Content Neutrality: A Defense [PDF]

open access: yes, 2019
To date, both the United States federal government and twenty-one individual states have passed Religious Freedom Restoration Acts that aim to protect religious persons from having their sincere beliefs substantially burdened by governmental interests ...
Dunne, Joseph
core  

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