Results 41 to 50 of about 124,503 (312)
Argumentation et Analyse du Discours, 2016 This article deals with the notion of “neutrality” within the context of Wikipedia. One of the "five pillar" guidance principles for editors on the website is named the "Neutral point of view", reflecting the website’s aspiration to ...
Rivka Dvira
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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Biochar, 2023 Highlights • Nanoparticle-decorated biochar as remediation materials fosters the attainment of soil remediation and sustainable agriculture. • The synthesis, characterization, soil remediation, and environmental effects of nanoparticle-decorated biochar ...
Tong Zheng, Shaohu Ouyang, Qixing Zhou
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FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
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Analiza i Egzystencja, 2016 In this paper I focus on the concept of neutrality taken in the meaning typical for political discussions concerning e.g. the religious neutrality of the state.
Arkadiusz Chrudzimski
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
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British Policy and Strategy in the Middle East in 1941: Three Wars ‘East of Suez’
Вестник Московского Университета. Серия XXV: Международные отношения и мировая политика, 2020 After the defeat of France in the summer of 1940, Great Britain was left face to face with the Nazi Germany. It managed to endure the first act of the ‘Battle of Britain’, but could not wage a full-scale war on the continent.
A. M. Fomin
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
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Revista Română pentru Studii Baltice şi Nordice, 2011 :In the summer of 1915, concerned about Italy's entry into the war in alliance with the Entente powers yet encouraged by the victories of its armies on the Eastern Front, the German diplomacy attempted to encourage Sweden and Romania to abandon their ...
Claudiu-Lucian Topor
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