Results 51 to 60 of about 124,503 (312)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
The Fundamental Reflections about Austrian Foreign Policy
Управленческое консультирование, 2018 The article represents the first of 30 chapters of the book «Ambition and Reality: Austria’s Foreign Policy since 1945», translated from German into Russian. The book is devoted to the analysis of the foreign policy of Austria since the end of the Second
K. I. Epshteyn-Wessely
doaj
Canadian Journal of Academic LibrarianshipNeutrality is often treated as a foundational value of librarianship, but its adoption was neither inevitable nor apolitical. This paper traces the historical development of neutrality within the profession, showing how it emerged in response to ...
Emily Jaeger-McEnroe
doaj +1 more source
HETEROSIS OR NEUTRALITY? [PDF]
Genetics, 1977 ABSTRACT Various statistics have been proposed on an ad hoc basis to test whether alleles at a locus are selectively neutral. By considering population models in which selection operates, this paper shows that the population homozygosity is a powerful test statistic for testing departures from neutrality, in the direction of heterozygote
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Network neutrality and the evolution of the internet [PDF]
In order to create incentives for Internet traffic providers not to discriminate with respect to certain applications on the basis of network capacity require-ments, the concept of market driven network neutrality is introduced. Its basic characteristics
Knieps, Günter
core +2 more sources
Carbon neutrality and business model
, 2023 openThis article first reviews the definition of carbon neutrality and the progress of the world's carbon neutral actions. Secondly, it discusses how enterprises, as the largest contributors to carbon emissions, should respond to the global movement of ...
ZHAO, ZIWEI
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Temporary Cabinet Foreign Policy: of Non – alignment to Neither West Nor East Principle [PDF]
Faṣlnāmah-i Pizhūhish/hā-yi Rāhburdī-i Siyāsat, 2014 Temporary Cabinet Foreign Policy: of Non – alignment to Neither West Nor East Principle Seyd Hasan Mir Fakhraei* (Received:2014/June/14 – Accept: 2014/Octobr/27) Abstract Foreign policy of the Bazargan cabinet is one of the most controversial ...
seyyed hassan Mirfakhrayi
doaj
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source