Angiotensin II and VEGF are Involved in Angiogenesis Induced by Short-Term Exercise Training [PDF]
, 2001 Results from our laboratory have suggested a pathway involving angiotensin II type 1 (AT1) receptors and vascular endothelial growth factor (VEGF) in angiogenesis induced by electrical stimulation.
Amaral, Sandra L. +2 more
core +2 more sources
Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function
Advanced Functional Materials, EarlyView.Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh +3 more
wiley +1 more source
SARS-CoV-2-Neutralizing Antibodies
VaccinesThe COVID-19 pandemic, triggered by the SARS-CoV-2 virus, has profoundly and permanently affected many aspects of the world [...]
Yawen Liu, Jianhui Nie
openaire +3 more sources
Advanced Functional Materials, EarlyView.FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu +5 more
wiley +1 more source
Reprogramming the antigen specificity of B cells using genome-editing technologies
eLife, 2019 We have developed a method to introduce novel paratopes into the human antibody repertoire by modifying the immunoglobulin (Ig) genes of mature B cells directly using genome editing technologies. We used CRISPR-Cas9 in a homology directed repair strategy,
James E Voss +18 more
doaj +1 more source
Predicting the effectiveness of hepatitis C virus neutralizing antibodies by bioinformatic analysis of conserved epitope residues using public sequence data [PDF]
, 2018 Hepatitis C virus (HCV) is a global health issue. Although direct-acting antivirals are available to target HCV, there is currently no vaccine. The diversity of the virus is a major obstacle to HCV vaccine development. One approach toward a vaccine is to
Cowton, Vanessa M. +3 more
core +2 more sources
A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies [PDF]
, 2020 Ahmed O. Hassan +21 more
openalex +1 more source
Advanced Functional Materials, EarlyView.A scalable biomimetic platform transforms bioinert poly(ethylene glycol) diacrylate into neuroinstructive matrices via integrating solvent transfer‐induced phase separation, microfluidics, and 3D bioprinting. Bicontinuous, hyperbolically curved microporous networks embedded within a fibrous construct elicit rapid adhesion, robust proliferation, and ...
Prince D. Okoro +8 more
wiley +1 more source
Prevalence of antibodies to four different rotavirus strains in different age groups of cattle [PDF]
, 1990 Neutralizing antibody titers to four bovine rotavirus strains, representing three serotypes, were measured in 160 sera from cattle of different age groups.
Büssow, Harald +3 more
core
Hemagglutinin sequence conservation guided stem immunogen design from influenza A H3 subtype [PDF]
, 2015 Seasonal epidemics caused by influenza A (H1 and H3 subtypes) and B viruses are a major global health threat. The traditional, trivalent influenza vaccines have limited efficacy because of rapid antigenic evolution of the circulating viruses.
Citron, Michael +6 more
core +4 more sources