Results 211 to 220 of about 1,881,376 (382)

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

The 2017 Keystone Symposium on HIV Vaccines

Human Vaccines & Immunotherapeutics, 2017
Christopher A. Cottrell, Andrew B. Ward
doaj   +1 more source

Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes [PDF]

, 2022
Yulu Chen, Fei Wang, Liwei Yin, Haihai Jiang, Xishan Lu, Yuhai Bi, Wei Zhang, Yi Shi, Roberto Burioni, Zhou Tong, Hao Song, Jianxun Qi, George F. Gao   +12 more
openalex   +1 more source

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo [PDF]

, 2017
Joshua A. Horwitz, Yotam Bar‐On, Ching-Lan Lu, Daniela Fera, Ainsley Lockhart, Julio C. C. Lorenzi, Lilian Nogueira, Jovana Golijanin, Johannes F. Scheid, Michael S. Seaman, Anna Gazumyan, Susan Zolla‐Pazner, Michel C. Nussenzweig   +12 more
openalex   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Differential immunity induced by Omicron sublineages in naïve and vaccine breakthrough infections

Scientific Reports
The emergence of the Omicron variant in late 2021 gave rise to multiple descendent lineages, or sublineages, with progressively increased capacity for antibody evasion.
Noah Brazer, Mary Kate Morris, Venice Servellita, Miriam Oseguera, Nanami Sumimoto, Prachi Saldhi, Abiodun Foresythe, Jenny Nguyen, Debra A. Wadford, Carl Hanson, Charles Y. Chiu   +10 more
doaj   +1 more source

Preventing escape from neutralizing antibodies [PDF]

Nature Reviews Immunology, 2020
openaire   +2 more sources

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

HIV neutralizing antibodies reignite interest in vaccine [PDF]

, 2012
Emily Waltz
openalex   +1 more source