Results 261 to 270 of about 207,642 (318)

Enhanced Clearance of HIV-1 Broadly Neutralizing Antibody VRC07-523-LS During Viremia: Influences on Trial Design and Analysis. [PDF]

Clin Transl Sci
Smith NM, Ho BM, Bar KJ, Gama L, Dziubla G, Koup RA, Pensiero M, Serebryannyy L, Caskey M, Wilkin TJ, Wood TD, Morse GD, Venuto CS, Cha R, Ma Q.   +14 more
europepmc   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Standardized neutralizing antibody assay for Coxsackievirus A10 in clinical trial: A framework for multivalent hand, foot, and mouth disease vaccine evaluation. [PDF]

Hum Vaccin Immunother
Wang Q, Li L, Gao J, Liu M, Wang Y, He Q, Wang W, Li Y, Gu M, Xie Z, Liu Q, Han J, Zhang Z, Guo J, Wu X, Mao Q, Chen X, Liang Z, Gao F, Ma X.   +19 more
europepmc   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Divalent HIV-1 gp120 Immunogen Exhibits Selective Avidity for Broadly Neutralizing Antibody VRC01 Precursors. [PDF]

Vaccines (Basel)
Bailey R, Kahoekapu K, To A, Mayerlen LI, Kae H, Manninen G, Haun BK, Berestecky JM, Shikuma C, Lehrer AT, MacPherson IS.   +10 more
europepmc   +1 more source

Bandgap‐Engineered PtxTey:Ag2Te Composite Quantum Dots Enable Programmable NIR‐II Imaging and Photothermal‐Immune Synergistic Therapy

Advanced Science, EarlyView.
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu, Rui Xu, Quan Wu, Tian‐Xin Xiao, Lai‐Xi Zhao, Lei Sun, Ya‐Wen Zheng, Liang Dong, Zhi‐Quan Tian, Haibo Wang   +9 more
wiley   +1 more source

Discovery and molecular mechanism of potent neutralizing antibody from humanized mice with respiratory syncytial virus. [PDF]

PLoS Pathog
Zhang Z, Feng R, Zhang L, Yang Q, Chen X, Wang X, Nie C, Peng W, Wang X, Zhu L, Guo Y, Sun Z.   +11 more
europepmc   +1 more source

Mechanism for evolution of diverse autologous antibodies upon broadly neutralizing antibody therapy of people with HIV. [PDF]

Cell Rep
Kannan D, Wang E, Deeks SG, Lewin SR, Chakraborty AK.   +4 more
europepmc   +1 more source

The N terminus of H3-influenza hemagglutinin as a site-of-vulnerability to neutralizing antibody. [PDF]

Structure
Rawi R, Morano NC, Cheung CS, Du H, Gorman J, Prabhakaran M, Becker JE, Bylund T, Charaf S, Chen X, Lee M, Harris DR, Olia AS, Ou L, Wang L, Wang S, Zhang B, Kanekiyo M, McDermott AB, Zhou T, Shapiro L, Kwong PD.   +21 more
europepmc   +1 more source

Prefusion-stabilized Hantaan virus glycoprotein nucleic acid vaccine elicits potent neutralizing antibody responses via germinal center activation. [PDF]

Nat Commun
Ye W, Dang Y, Wang Y, Yang Q, Zhang H, Ye C, Wei J, Pei J, Pei X, Jiang D, Yang X, Jin X, Ma H, Liu H, Zhang L, Cheng L, Dong Y, Lei Y, Xu Z, Zhang F.   +19 more
europepmc   +1 more source