Results 311 to 320 of about 1,881,376 (382)

Neutralizing Antibody Response Characteristics in Elderly Patients with SARS-CoV-2 Infection and Their Association with Clinical Phenotypes. [PDF]

Vaccines (Basel)
Li Y, Wang L, Ma J, Geng W, Wang Y.
europepmc   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Assessment of SARS-CoV-2 neutralizing antibody persistence using LFIC: a prevalence study after booster doses. [PDF]

BMC Public Health
Montagud AC, Moragues R, Gabaldón-Bravo EM, Hurtado-Sánchez JA, Tuells J.   +4 more
europepmc   +1 more source

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, EarlyView.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2. [PDF]

J Exp Med
Changrob S, Yasuhara A, Park S, Bangaru S, Li L, Troxell CA, Halfmann PJ, Erickson SA, Catanzaro NJ, Yuan M, Zhou P, Huang M, Wilbanks GD, McGrath JJC, Singh G, Nelson SA, Fu Y, Zheng NY, Carayannopoulos SM, Dugan HL, Shaw DG, Stamper CT, Madariaga MLL, Krammer F, Andrabi R, Burton DR, Ward AB, Wilson IA, Kawaoka Y, Wilson PC.   +29 more
europepmc   +1 more source

Neutralizing Anti-Drug Antibody [PDF]

, 2020
openaire   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates. [PDF]

Sci Immunol
Sutton HJ, Ma KM, Steichen JM, Schiffner T, Altheide TK, Liguori A, Lu D, Kubitz M, Georgeson E, Phelps N, Tingle R, Alavi NB, Ben-Akiva E, Zhou X, Kifude C, Flynn CT, Rakasz E, Irvine DJ, Schief WR, Crotty S.   +19 more
europepmc   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

<i>In Vivo</i> engineering of transgenic mice for systemic human neutralizing antibody production against staphylococcal enterotoxin B. [PDF]

Front Immunol
Jiang Z, Jia B, Hu N, Zhang M, Xiao H, Chen G, Yu J, Li X, Shen B, Feng J, Wang J.   +10 more
europepmc   +1 more source