Results 331 to 340 of about 1,881,376 (382)

Development and validation of a blocking ELISA for measurement of rabies virus neutralizing antibody. [PDF]

J Clin Microbiol
Xiao Y, Wu M, Xu W, Sun S, Liu T, Liu Y, Li H, Feng N, Tu C, Feng Y.   +9 more
europepmc   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

Direct airway delivery of a humanized anti-H7N9 neutralizing antibody broadly protects against divergent H7 influenza viruses in the mouse model. [PDF]

J Virol
Yu W, He X, Zhao J, Dou Y, Hu T, Chen X, Ma X, Wang X, Hu S, Hu J, Liu X, Hu Z.   +11 more
europepmc   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models. [PDF]

Front Immunol
Stromberg ZR, Silva EE, Johnston SC, Johnson DM, Hall D, Adjei EF, Altin JA, Abisoye-Ogunniyan A, Gollott T, He W, Jones IKA, Kwilas S, Lund SJ, Mead HL, Nelson GA, Ouyang L, Peters SKG, Schwedler JL, Trecazzi CZ, Turner MW, Ye C, Bradfute SB, Fischer NO, Hooper JW, Ladner JT, Rasley A, Negrete OA.   +26 more
europepmc   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Broad neutralizing antibody response of a monomeric spike-based SARS-CoV-2 bivalent vaccine against diverse variants. [PDF]

Proc Natl Acad Sci U S A
Wang S, Sun H, Wang Y, Wang Z, Yuan L, Guo H, Gao J, Lan M, Wu Y, Shang H, Chen X, Chen Z, Hu J, Tang Z, Wen G, Ying D, Liu C, Jiang Y, Su J, Lin M, Wu T, Li S, Zhang T, Zhang J, Guan Y, Xia N, Yuan Q, Zheng Q, Zhang Y, Zheng Z.   +29 more
europepmc   +1 more source

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

IL-17-neutralizing antibody mitigates functional and structural changes in cigarette smoke-induced COPD model. [PDF]

Front Immunol
Riani Moreira A, Uchoa da Silva C, de Paula Costa Mattos L, Jesus Simão J, Camargo Berti V, Henrique Vasconcelos Alves L, Ferreira da Silva A, Jesus Lima F, Karoline Moreira Bezerra S, Nascimento Silva C, Cardoso Allonso-Vale MI, de Fatima Lopes Calvo Tiberio I, Maria Almeida F, Degobbi Tenorio Quirino Dos Santos Lopes F.   +13 more
europepmc   +1 more source