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Neutralization of HIV by Antibodies
2008Antibodies can neutralize HIV-1 with potency and cross-reactivity that varies widely and is related but not correlated to their antigen-binding affinity. Therefore, in addition to measuring binding affinity, an evaluation of the antibody neutralizing activity in tissue cultures is important for development of antibody-based therapeutics, design of ...
Ilia Prado +2 more
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Testing for neutralizing antibodies
British Journal of Neuroscience Nursing, 2007Interferon-beta drugs for multiple sclerosis sometimes give rise to immune proteins that neutralize their effects. Nicola O'Connell and Bronwen Roper look at testing for these neutralizing antibodies
Nicola O'Connell, Bronwen Roper
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Neutralizing antibodies to interferon
Neurology, 2007The impact of neutralizing antibodies (NAbs) to interferon-beta (IFN-beta) on clinical and imaging parameters in multiple sclerosis (MS) is reviewed. An effect on relapse rates and imaging parameters was noted in patients who tested positive for NAbs, but disability measures were unaffected or showed a trend toward improvement.
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Neutralizing antibody in rodent malaria
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1975Small numbers of rat erythrocytes infected with viable P. berghei, when inoculated into susceptible rats together with hyperimmune rat serum (HIS), are fully neutralized. Serum from convalescent rats delays the onset of patency but does not neutralize. The neutralizing efficiency of HIS rises in proportion to the number of successive reinoculations of ...
A. Zuckerman +2 more
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Antibody Neutralization in Hypoprothrombinaemic Plasma
Pathophysiology of Haemostasis and Thrombosis, 1972The technique of antibody neutralization has been used to study the plasma of a large group of patients with hypoprothrombinaemia of diverse causes. The associated disorders included obstructive jaundice, acute infective hepatitis and chronic parenchymal liver disease. A number of patients were receiving warfarin and salicylate therapy. Irrespective of
P.A. Castaldi, F. Madaras, J.D. Parkin
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Neutralizing antibody in nonallergic individuals
Journal of Allergy, 1952Abstract Neutralizing antibody titrations were carried out in series of nonatopic human volunteers receiving one of the following ragweed preparations: (1) aqueous, (2) dialyzed aqueous, (3) alum precipitated, and (4) tannic acid precipitated extract. Also, extracts were made up to contain one of the following: (5) 10 per cent polyvinylpyrrolidone, (6)
Saul Malkiel, Samuel M. Feinberg
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Protective neutralizing antibodies
Science, 2020Coronavirus Antibodies produced by survivors of coronavirus disease 2019 (COVID-19) may be leveraged to develop therapies. A first step is identifying neutralizing antibodies, which confer strong protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Rogers et al.
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The secretion of virus-neutralizing antibodies
Archiv f�r die gesamte Virusforschung, 1967Considerable evidence supports the concept that the immune defense against infectious agents that attack primarily the cells of the mucosal linings lies in secreted antibodies belonging to the IgA class of immunoglobulins. The problem that thus arises, in connection with the possible use of adjuvants in active immunization against these infectious ...
B. Pernis +4 more
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Neutralization of Arenaviruses by Antibody
1987Neutralization of infectivity is the end result of a number of alternative or synergistic reactions between a virus and antibody directed against certain antigenic determinants on its surface. These reactions prevent either the attachment of virus to a particular host cell by steric hindrance, the entry of virus into the cell, or the uncoating of the ...
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Neutralizing Antibodies Against Calcitonin
Hormone and Metabolic Research, 1993The use of calcitonin (CT) is established as a treatment of Paget's disease of bone and postmenopausal osteoporosis (PMO). Salmon calcitonin (sCT), which differs in 14 of the 32 amino acids from human calcitonin, has found a wider distribution world wide, although antibody formation against sCT has been reported in more than 70% of the patients on ...
Andreas Grauer +3 more
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