Results 31 to 40 of about 289,586 (356)

RSV Neutralizing Antibodies in Dried Blood

The Journal of Infectious Diseases, 2023
Abstract Background The key correlate of protection of respiratory syncytial virus (RSV) vaccines and monoclonal antibodies (mAbs) is virus neutralization, measured via sera obtained through venipuncture.
Jonne Terstappen, Eveline M Delemarre, Anouk Versnel, Joleen T White, Alexandrine Derrien-Colemyn, Tracy J Ruckwardt, Louis J Bont, Natalie I Mazur   +7 more
openaire   +3 more sources

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

iScience, 2022
Summary: The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding and ...
Fangzhu Zhao, Celina Keating, Gabriel Ozorowski, Namir Shaabani, Irene M. Francino-Urdaniz, Shawn Barman, Oliver Limbo, Alison Burns, Panpan Zhou, Michael J. Ricciardi, Jordan Woehl, Quoc Tran, Hannah L. Turner, Linghang Peng, Deli Huang, David Nemazee, Raiees Andrabi, Devin Sok, John R. Teijaro, Timothy A. Whitehead, Andrew B. Ward, Dennis R. Burton, Joseph G. Jardine   +22 more
doaj  

bNAber: database of broadly neutralizing HIV antibodies. [PDF]

, 2013
The discovery of broadly neutralizing antibodies (bNAbs) has provided an enormous impetus to the HIV vaccine research and to entire immunology. The bNAber database at http://bNAber.org provides open, user-friendly access to detailed data on the rapidly ...
Burton, Dennis R, Butera, Sal T, Eroshkin, Alexey M, Godzik, Adam, LeBlanc, Andrew, Li, Zhanwen, Post, Kai, Rajput, Akhil, Weekes, Dana   +8 more
core   +4 more sources

Coupling of HIV-1 gp120-derived Core Protein to Paramagnetic Beads and Adsorption Assays

Bio-Protocol, 2015
Analysis of the functional activity in polyclonal serum following immunization of a complex protein or glycoprotein immunogen is a very important but tedious process.
Jidnyasa Ingale, Richard Wyatt
doaj   +1 more source

Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys. [PDF]

PLoS Pathogens, 2007
Prophylaxis with high doses of neutralizing antibody typically offers protection against challenge with viruses producing acute infections. In this study, we have investigated the ability of the neutralizing human monoclonal antibody, KZ52, to protect ...
Wendelien B Oswald, Thomas W Geisbert, Kelly J Davis, Joan B Geisbert, Nancy J Sullivan, Peter B Jahrling, Paul W H I Parren, Dennis R Burton   +7 more
doaj   +1 more source

Insights into neutralization of animal viruses gained from study of influenza virus [PDF]

, 1991
It has long been known that the binding of antibodies to viruses can result in a loss of infectivity, or neutralization, but little is understood of the mechanism or mechanisms of this process.
Colonno, Dimmock, Eisenlohr, Kennedy-Stoskopf, Kjellen, Kukuhara, Lamb, M. C. Outlaw, Mandel, Mandel, Mandel, McClure, N. J. Dimmock, Svehag, Thomas, Thomas, Viitala, Wharton   +17 more
core   +2 more sources

An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP+ mononuclear cells and PDGF-BB secretion

Bone Research, 2021
Osteoporosis (OP) is a common age-related disease characterized by a deterioration of bone mass and structure that predisposes patients to fragility fractures.
Gehua Zhen, Yang Dan, Ruomei Wang, Ce Dou, Qiaoyue Guo, Melissa Zarr, Linda N. Liu, Lieping Chen, Ruoxian Deng, Yusheng Li, Zengwu Shao, Xu Cao   +11 more
doaj   +1 more source

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

Nature Communications, 2019
Stabilized, native-like trimers of the HIV envelope protein, such as SOSIP trimers, are potential antigens for an HIV vaccine. Here, the authors generate a SOSIP trimer based on the consensus sequence of group M isolates, determine its structure and ...
Kwinten Sliepen, Byung Woo Han, Ilja Bontjer, Petra Mooij, Fernando Garces, Anna-Janina Behrens, Kimmo Rantalainen, Sonu Kumar, Anita Sarkar, Philip J. M. Brouwer, Yuanzi Hua, Monica Tolazzi, Edith Schermer, Jonathan L. Torres, Gabriel Ozorowski, Patricia van der Woude, Alba Torrents de la Peña, Mariëlle J. van Breemen, Juan Miguel Camacho-Sánchez, Judith A. Burger, Max Medina-Ramírez, Nuria González, Jose Alcami, Celia LaBranche, Gabriella Scarlatti, Marit J. van Gils, Max Crispin, David C. Montefiori, Andrew B. Ward, Gerrit Koopman, John P. Moore, Robin J. Shattock, Willy M. Bogers, Ian A. Wilson, Rogier W. Sanders   +34 more
doaj   +1 more source

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans [PDF]

, 2013
Rabies kills many people throughout the developing world every year. The murine monoclonal antibody (mAb) 62-71-3 was recently identified for its potential application in rabies postexposure prophylaxis (PEP).
Anthony R. Fooks, Ashley C. Banyard, Bardor M., Benmansour A., Bianca Bulmer‐Thomas, Constantine D. G., Craig Dolleweerd, David Selden, Dietzschold B., Dietzschold B., Dietzschold B., Edward Wright, Fooks A. R., Friedrich Altmann, Gomord V., Hampson K., Hultberg A., Julian K.‐C. Ma, Knobel D. L., Lafay F., Lafon M., Leonard Both, Luo T. R., Ma J. K., Manning S. E., Mansfield K. L., McCormick A. A., Muhamuda K., Müller T., Prehaud C., Satpathy D. M., Seif I., Shantavasinkul P., Sudarshan M. K., Tacket C. O., Tekoah Y., Van Ree R., Warrell M., Wertheim H. F. L., World Health Organization, World Health Organization, Wright E., Zeitlin L.   +42 more
core   +1 more source

Neutralizing antiviral antibody responses

, 2001
Neutralizing antibodies are evolutionarily important effectors of immunity against viruses. Their evaluation has revealed a number of basic insights into specificity, rules of reactivity (tolerance), and memory—namely, (1) Specificity of neutralizing antibodies is defined by their capacity to distinguish between virus serotypes; (2) B cell reactivity ...
Zinkernagel, R, LaMarre, A, Ciurea, A, Hunziker, L, Ochsenbein, A, McCoy, K, Fehr, T, Bachmann, M, Kalinke, U, Hengartner, H   +9 more
openaire   +3 more sources