Results 31 to 40 of about 1,881,376 (382)
Cell Reports, 2015 Viral glycoproteins mediate entry by pH-activated or receptor-engaged activation and exist in metastable pre-fusogenic states that may be stabilized by directed rational design. As recently reported, the conformationally fixed HIV-1 envelope glycoprotein
Shailendra Kumar Sharma +8 more
doaj +1 more source
Efficient isolation of rare B cells using next-generation antigen barcoding
Frontiers in Cellular and Infection Microbiology, 2023 The ability to efficiently isolate antigen-specific B cells in high throughput will greatly accelerate the discovery of therapeutic monoclonal antibodies (mAbs) and catalyze rational vaccine development.
Jonathan Hurtado +36 more
doaj +1 more source
Platelet-collagen adhesion: evidence for participation of antigenically distinct entities. [PDF]
, 1984 Univalent antibody fragments prepared from a rabbit antiserum raised against whole human platelets completely inhibited adhesion of platelets to immobilized trimeric collagen in a defined, Mg2+-dependent, adhesion assay.
Barondes, SH, Shadle, PJ
core +2 more sources
Cell Reports, 2016 A major advance in the search for an HIV vaccine has been the development of a near-native Envelope trimer (BG505 SOSIP.664) that can induce robust autologous Tier 2 neutralization.
Laura E. McCoy +18 more
doaj +1 more source
Scientific Reports, 2021 The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and their association with disease severity.
B. Trinité +25 more
semanticscholar +1 more source
IgA dominates the early neutralizing antibody response to SARS-CoV-2
Science Translational Medicine, 2020 Early specific antibody responses against SARS-CoV-2 include IgG, IgM, and IgA, but IgA may neutralize virus and control infection to a larger extent.
D. Sterlin +26 more
semanticscholar +1 more source
bioRxiv, 2021 The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine efficacy. Here, neutralizing antibody titers elicited by mRNA-based and an adenoviral vector-based vaccine against variant pseudotyped viruses ...
Takuya Tada +6 more
semanticscholar +1 more source
A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein
Nature Communications, 2021 Vaccines and therapeutics are urgently needed for the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we screen human monoclonal antibodies (mAb) targeting the receptor binding domain (RBD) of the viral spike ...
Cheolmin Kim +44 more
semanticscholar +1 more source
Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses
Journal of Experimental Medicine, 2020 The emergence of SARS-CoV-2 has created a need for robust assays of plasma and monoclonal antibody neutralization potency. Pseudotyped HIV-1– and vesicular stomatitis virus–based reporter viruses and a replication-competent vesicular stomatitis virus ...
F. Schmidt +20 more
semanticscholar +2 more sources
SnapShot: Broadly Neutralizing Antibodies
Cell, 2013 Durably elicited by live attenuated virus, less durably by inactivated virusConserved bnAb epitopes:1) Ep1 (res. 380–400) 2) Ep2 (res. 190–200)3) Ep3 (res. 571–579)Despite the extensive variability of measles virus, nAb responses to vaccination are broad becausethe conserved epitopes are immunoprominent.May relate to overlap of the receptor-binding ...
Sok, Devin +2 more
openaire +2 more sources