Results 61 to 70 of about 289,824 (354)

Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies [PDF]

, 2013
Hepatitis C virus (HCV) infection is a major cause of liver disease and hepatocellular carcinoma. Glycan shielding has been proposed to be a mechanism by which HCV masks broadly neutralizing epitopes on its viral glycoproteins.
Adams, Alex Brown, Angus, Arvind H. Patel, Bartenschlager, Benedicto, Blight, Bradley, Broering, Bukh, Charles Eigenbrot, David Arnott, David J. Matthews, Dhillon, Diao, Emsley, Evans, Falkowska, Flint, Friebe, Gadgil, Gal-Tanamy, Giang, Goffard, Gordon, Helle, Helle, Herweijer, Homer Pantua, Hotzel, Iacob, Jingyu Diao, Jo-Anne Hongo, Kapadia, Kapadia, Kentaro Takeda, Kong, Kong, Krista McCutcheon, Lindenbach, Liu, Livak, Mark Ultsch, Mary Mathieu, McCaffrey, McCoy, Meredith Hazen, Moore, Murshudov, North, Otwinowski, Owsianka, Owsianka, Owsianka, Owsianka, Paborsky, Perotti, Phil Hass, Pikora, Pileri, Ploss, Potter, Qui Phung, Reed, Reesink, Robert F. Kelley, Sainz, Sarrazin, Scarselli, Shailesh Date, Sharookh B. Kapadia, Tommy K. Cheung, Trowbridge, Tsukiyama-Kohara, Utachee, Wang, Wei, Yi, Yi, Zhang, Zhang, Zhong   +81 more
core   +1 more source

Natural Evolution of Broadly Neutralizing Antibodies [PDF]

Cell, 2015
Wu et al. couple next-generation sequencing with structural analysis to illuminate the key processes that enable the natural evolution and selection of broadly neutralizing antibodies to HIV-1, providing a potential roadmap for the development of HIV-1 vaccine strategies to accelerate the induction of protective antibodies.
Galit Alter, Dan H. Barouch, Dan H. Barouch   +2 more
openaire   +3 more sources

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Serum neutralizing antibody following the vaccination of inactivated SARS-CoV-2 vaccines

Shanghai yufang yixue, 2023
ObjectiveTo determine the difference of serum neutralizing antibody levels in healthy persons following the vaccination of inactivated SARS-CoV-2 vaccines.MethodsHealth care workers that received inactivated SARS-CoV-2 vaccines were enrolled in Sichuan ...
FU Chunyan, JIANG Li, HUANG Yi
doaj   +1 more source

The Role of Follicular Dendritic Cells in Human Immunodeficiency Virus Pathogenesis [PDF]

, 1995
Infection with Human Immunodeficiency Virus-1(HIV) results in a disease process characterized by three stages: an acute phase characterized by viremia, a clinically latent stage with little or no detection of virus in the blood, and the last stage, AIDS,
Heath, Sonya Lynn
core   +1 more source

Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. [PDF]

, 2020
On 10 January 2020, a new coronavirus causing a pneumonia outbreak in Wuhan City in central China was denoted as 2019-nCoV by the World Health Organization (WHO).
Du, Lanying, Jiang, Shibo, Ojcius, David M, Pan, Chungen, Yu, Fei   +4 more
core   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Role of the Antigen Capture Pathway in the Induction of a Neutralizing Antibody Response to Anthrax Protective Antigen

mBio, 2018
Toxin neutralizing antibodies represent the major mode of protective immunity against a number of toxin-mediated bacterial diseases, including anthrax; however, the cellular mechanisms that lead to optimal neutralizing antibody responses remain ill ...
Anita Verma, Miriam M. Ngundi, Gregory A. Price, Kazuyo Takeda, James Yu, Drusilla L. Burns   +5 more
doaj   +1 more source

Analysis of Factors Affecting Neutralizing Antibody Production after COVID-19 Vaccination Using Newly Developed Rapid Point-of-Care Test

Diagnostics, 2022
(1) Objective: To investigate the factors that affect rates of neutralizing antibody production and duration after vaccination using the newly developed SARS-CoV-2 POCT.
Hyeon Woo Shim, Jae hang Shin, Shang Cheol Shin, Hwa Jung Lee, Kyung Soon So, So Young Lee, Jae Woo Jun, Jeong Ku Seo, Hwa Seop Lee, Suk Young Lee, Seung Hyun Kim, Sun Jong Kim, Kyoung-Chol Kim, Gyu Ha Ryu   +13 more
doaj   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source