Results 101 to 110 of about 220,141 (335)

Diagnosis of autoimmune neutropenia in a 10-month-old boy – a case report [PDF]

, 2021
Katarzyna Zdanowicz, Urszula Daniluk, Elena Jewsiejenko, Milena Krasnodębska, Safa Meshaal, Dariusz Lebensztejn   +5 more
openalex   +1 more source

Efficacy and safety of empagliflozin for treating neutropenia and neutrophil dysfunction in paediatric patients with glycogen storage disease type Ib: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk, Ryan Jin, Fabio Tuzzolino, Giusy Ranucci, Donatella Madonia, Alessio Provenzani   +5 more
wiley   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Model‐informed precision dosing of carboplatin in cancer patients by leveraging myelosuppression data from electronic health records

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This study aimed to develop and validate a population pharmacokinetic‐pharmacodynamic (pop‐PK‐PD) model to describe carboplatin‐induced myelosuppression in cancer patients and support dose individualization. Methods Data from 580 cancer patients treated with carboplatin at Amsterdam UMC between 2019 and 2022 were used for model ...
Alessandro De Carlo, Elena Maria Tosca, Mirjam Crul, Tim Schutte, Lia van Zuijlen, Idris Bahce, Medhat M. Said, Jan Buter, Harmen Huls, Paolo Magni, Imke Bartelink   +10 more
wiley   +1 more source

Treatment of severe neutropenia with high-dose pyridoxine in a patient with chronic graft versus host disease and squamous cell carcinoma: a case report

Journal of Medical Case Reports, 2011
Introduction The differential diagnosis of neutropenia includes medications, infections, autoimmune diseases, and deficiencies of Vitamin B12 and folate. The association of Vitamin B6 deficiency with severe neutropenia is a rare finding.
Rauf Mariam, Gleason Charise, Nooka Ajay K, Husman Abbie, Waller Edmund K   +4 more
doaj   +1 more source

Time to antibiotic administration (TTA) and its impact on outcome: A single center retrospective study on children with febrile neutropenia

, 2023
Shreyasi Das, Swetlana Mukherjee, Sneha Bhosal, Amita Mahajan   +3 more
openalex   +1 more source

203. Opportunities for Antimicrobial Stewardship in Febrile Neutropenia [PDF]

, 2020
Christopher Shoff, Jordan Baskett, Julia A. Messina, Arthur W. Baker, Nicholas Turner, Justin Spivey, Rebekah Wrenn, Rebekah W. Moehring, Steven S Spires   +8 more
openalex   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Hipoksia Jaringan dan Kadar Laktat pada Leukemia Limfoblastik Akut dengan Demam Neutropenia dalam Fase Induksi

Sari Pediatri, 2016
Latar belakang. Pada Leukemia limfoblastik akut (LLA), proses fagositosis oleh neutrofil kurang atau tidak efektif (kondisi neutropenia) memungkinkan bertahannya bakteri yang tidak dapat didigesti, sehingga timbul proses inflamasi yang selanjutnya dapat ...
Nusarintowati Ramadhina, Endang Windiastuti, H.I. Budiman   +2 more
doaj   +1 more source

Population pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia

British Journal of Clinical Pharmacology, EarlyView.
Background Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.
Andrew M. Brandon, Hinke Huisman‐Siebinga, Shelby Barnett, Paul Wetherell, Pamela Kearns, Brenda Gibson, Nicholas Heaney, Owen Smith, André Baruchel, Arnaud Petit, Andrew Moore, Kayode Ogungbenro, Alwin D. R. Huitema, Gareth J. Veal   +13 more
wiley   +1 more source