Results 111 to 120 of about 274,076 (393)

Feasibility and population exposure of 5‐fluorouracil using therapeutic drug monitoring (PREDICT‐5FU): A multicentre clinical trial

British Journal of Clinical Pharmacology, EarlyView.
Aim PREDICT‐5FU aimed to document 5‐fluorouracil (5FU) exposure in a cancer population and to evaluate the feasibility of 5FU and capecitabine therapeutic drug monitoring (TDM) in patients receiving standard doses and schedules. Methods Multicentre, prospective, observational single‐arm study.
Sarah Glewis, Michael Michael, Howard Gurney, Ian Olver, Nicholas Zdenkowski, Stephen Ackland, Craig Kukard, Madawa Jayawardana, S. Sandun M. Silva, Marliese Alexander, Jeanne Tie, Peter Galettis, Jennifer H. Martin   +12 more
wiley   +1 more source

Level of Knowledge and Incidence of Emergency Oncology: Febrile Neutropenia in Hematologic Cancer Patients Post Chemotherapy: A Descriptive Study

Masker Medika
Introduction: Febrile neutropenia is a life-threatening condition that is the most common oncological emergency, especially in cases of hematological cancer. Knowledge related to this condition can accelerate treatment and reduce mortality. The danger of
Agus Suryaman
doaj   +1 more source

Phase II study of TP300 in patients with advanced gastric or gastro-oesophageal junction adenocarcinoma [PDF]

, 2016
Background: TP300, a recently developed synthetic camptothecin analogue, is a highly selective topoisomerase I inhibitor. A phase I study showed good safety and tolerability.
D. Alan Anthoney, Daniel Ford, David Propper, Keith Jones, Martin Eatock, Masaichi Abe, Michiyasu Inatani, Roshan Agarwal, T. R. Jeffry Evans, Tomohisa Saito, Wasat Mansoor   +10 more
core   +2 more sources

Bayesian data assimilation to support informed decision-making in individualised chemotherapy [PDF]

arXiv, 2019
An essential component of therapeutic drug/biomarker monitoring (TDM) is to combine patient data with prior knowledge for model-based predictions of therapy outcomes. Current Bayesian forecasting tools typically rely only on the most probable model parameters (maximum a-posteriori (MAP) estimate).
arxiv  

Assessment of ethnic differences in pharmacokinetics and clinical responses of acalabrutinib between Chinese and White patients with B‐cell malignancies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of this study was to assess differences between Chinese and White patients in pharmacokinetics (PK) of, and clinical response to, acalabrutinib and its pharmacologically active major metabolite, ACP‐5862, to support recommended dosing in Chinese patients with B‐cell malignancies.
Tingting Yao, Junjie Ding, Shringi Sharma, Yunfei Li, Qianwei Xu, Peiming Ma   +5 more
wiley   +1 more source

Chronic Severe Neutropenia Associated With Intravenous Immunoglobulin for Multifocal Motor Neuropathy

eJHaem
Intravenous immunoglobulin (IVIG) is an immunomodulatory therapy derived from pooled donor immunoglobulins and used for treatment of various autoimmune conditions.
Shannon Ugarte, Talia Gebhard, David R. Cornblath, Steven S. Scherer, Daria V. Babushok   +4 more
doaj   +1 more source

Adjuvant Chemotherapy for Breast Cancer in a Patient with Primary Autoimmune Neutropenia

Breast Cancer: Basic and Clinical Research, 2013
We report an extremely rare and complex case of a 44-year-old woman diagnosed with an early stage triple negative breast cancer in the setting of primary autoimmune neutropenia with a pre-existing severe neutropenia.
Michael Trus, Kavita Dhamanaskar, Jayson Potts, Parveen Wasi, Satvir Bains, Louise Bordeleau   +5 more
doaj   +1 more source

Mechanism-based model characterizing bidirectional interaction between PEGylated liposomal CKD-602 (S-CKD602) and monocytes in cancer patients [PDF]

, 2012
S-CKD602 is a PEGylated liposomal formulation of CKD-602, a potent topoisomerase I inhibitor. The objective of this study was to characterize the bidirectional pharmacokinetic-pharmacodynamic (PK-PD) interaction between S-CKD602 and monocytes.
Bang YJ, Belani CP, DM, Edwards RP, Friedl, Maruca LJ, Ramalingam S, Ramanathan RK, Stoller RG, Strychor S, Wu H, Zamboni BA, Zamboni WC   +12 more
core   +2 more sources

Model-based optimal AML consolidation treatment [PDF]

arXiv, 2019
Neutropenia is an adverse event commonly arising during intensive chemotherapy of acute myeloid leukemia (AML). It is often associated with infectious complications. Mathematical modeling, simulation, and optimization of the treatment process would be a valuable tool to support clinical decision making, potentially resulting in less severe side effects
arxiv  

Safety of sulfamethoxazole–trimethoprim for the treatment of bacterial infection in outpatient settings: A systematic review and meta‐analysis with active comparator disproportionality analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Sulfamethoxazole–trimethoprim (SMX‐TMP) is a widely used antibiotic for treating bacterial infections, but its safety in adult outpatients remains understudied. This systematic review and meta‐analysis evaluated the safety profile of SMX‐TMP and identified critical research gaps.
Rebecca Preyra, Lujain Ez Eddin, Fatemeh Ahmadi, Atefeh Jafari, Flory T. Muanda   +4 more
wiley   +1 more source