Results 121 to 130 of about 50,090 (336)

What makes gouty inflammation so variable? [PDF]

, 2017
Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem.
Terkeltaub, Robert
core   +2 more sources

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Airborne 1O2 Delivery via a Superhydrophobic Dressing as a Pathway to Next‐Generation Wound Therapies, an in Vivo Murine Burn Model Study

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral, QianFeng Xu, Natalie Eidenschink, Pareesha Haresh, Alessandra Nara de Souza Rastelli, Jeremy Goverman, Alexander Greer, Alan M. Lyons, Tayyaba Hasan   +8 more
wiley   +1 more source

Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome

Nature Communications, 2019
Antiphospholipid syndrome is characterised by increased neutrophil extracellular trap formation (NETosis) and, consequently, increased thrombotic events. Here Ali et al.
Ramadan A. Ali, Alex A. Gandhi, He Meng, Srilakshmi Yalavarthi, Andrew P. Vreede, Shanea K. Estes, Olivia R. Palmer, Paula L. Bockenstedt, David J. Pinsky, Joan M. Greve, Jose A. Diaz, Yogendra Kanthi, Jason S. Knight   +12 more
doaj   +1 more source

Platelets as mediators of Thromboinflammation in chronic Myeloproliferative Neoplasms [PDF]

, 2019
Chronic myeloproliferative neoplasms (MPN) are stem cell disorders driven by mutations in JAK2, CALR, or MPL genes and characterized by myeloid proliferation and increased blood cell counts.
Heller, Paula Graciela, Marin Oyarzún, Cecilia Paola   +1 more
core   +1 more source

Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets

Journal of Leukocyte Biology, 2016
In addition to being key elements in hemostasis and thrombosis, platelets amplify neutrophil function. We aimed to gain further insight into the stimuli, mediators, molecular pathways, and regulation of neutrophil extracellular trap formation mediated by
Agostina Carestia, T. Kaufman, Leonardo Rivadeneyra, V. Landoni, R. Pozner, S. Negrotto, L. D’Atri, R. Gómez, M. Schattner   +8 more
semanticscholar   +1 more source

Neutrophils in lung cancer patients: Activation potential and neutrophil extracellular trap formation

Research and Practice in Thrombosis and Haemostasis, 2023
Patients with cancer have an increased risk of developing venous thromboembolism. Neutrophils and neutrophil extracellular traps (NETs) reportedly influence the risk of cancer-associated thrombosis. Subpopulations of high and low-density neutrophils (HDN/LDN) are of specific interest, as they might have different functions in cancer patients.We aimed ...
Lisa-Marie, Mauracher, Lena, Hell, Florian, Moik, Moritz, Krall, Cornelia, Englisch, Johanna, Roiß, Ella, Grilz, Thomas M, Hofbauer, Christine, Brostjan, Sylvia, Knapp, Cihan, Ay, Ingrid, Pabinger   +11 more
openaire   +2 more sources

Mitochondrial Transplantation via Magnetically Responsive Artificial Cells Promotes Intracerebral Hemorrhage Recovery by Supporting Microglia Immunological Homeostasis

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
A type of magnetically responsive artificial cells (ACs) has been developed, demonstrating the loading of mitochondria and self‐enclosure processes to ensure the protection of mitochondrial transport via the bloodstream. The treatment with ACs effectively transplanted mitochondria around the lesion, thereby improving neurological recovery by supporting
Mi Zhou, Jinhui Zang, Yuxuan Qian, Qiang Zhang, Yifan Wang, Tingting Yao, Hongyu Yan, Kai Zhang, Xiaojun Cai, Lixian Jiang, Yuanyi Zheng   +10 more
wiley   +1 more source

Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity [PDF]

, 2015
Recently, we showed that endothelial heparan sulfate facilitates entry of a bacterial pathogen into the central nervous system. Here, we show that normal bactericidal activity of neutrophils is influenced by the sulfation pattern of heparan sulfate ...
Brinkmann, Volker, Chang, Yung-Chi, Cole, Jason N, Esko, Jeffrey D, Nizet, Victor, Olson, Joshua, van Wijk, Xander M, Xu, Ding, Zychlinsky, Arturo   +8 more
core   +1 more source

Mac‐1 triggers neutrophil DNA extracellular trap formation to Aspergillus fumigatus independently of PAD4 histone citrullination

Journal of Leukocyte Biology, 2020
Aspergillus fumigatus (A. fumigatus) is an environmental fungus and a human pathogen. Neutrophils are critical effector cells during the fungal infections, and neutropenia is a risk factor for the development of pulmonary aspergillosis.
J. C. Silva, Najara C. Rodrigues, Glaucia A. Thompson-Souza, Valdirene S. Muniz, J. S. Neves, R. Figueiredo   +5 more
semanticscholar   +1 more source