Results 141 to 150 of about 50,090 (336)

Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. [PDF]

, 2012
Antineutrophil cytoplasmic antibodies (ANCAs) target proteins normally retained within neutrophils, indicating that cell death is involved in the autoimmunity process. Still, ANCA pathogenesis remains obscure.
Abdgawad, Alcorta, Barbara Cappetti, Bennett, Bianchi, Brinkmann, Carla Guarnotta, Cassatella, Caterina Vitali, Chin, Claudia Chiodoni, Claudio Tripodo, Clayton, Colombo, Cristiana Guiducci, Di Carlo, Dittmar, Donnelly, Drenkard, Falk, Fuchs, Gaipl, Galeazzi, Garcia-Romo, Gilligan, Griffith, Guiducci, Jarius, Kantari, Kessenbrock, Lande, Manolova, Mariella Parenza, Mario P. Colombo, Martinelli, Metzler, Munafo, Nagata, Nathan, Patrizia Casalini, Patry, Potter, Pradhan, Remijsen, Sabina Sangaletti, Sangaletti, Santiago-Raber, Silvia Piconese, Specks, Spronk, Steinman, Tripodo, van der Geld, van Timmeren, Villanueva, Wernick, Witko-Sarsat, Ziegler-Heitbrock   +57 more
core   +1 more source

Substantially Altered Local and Systemic Immunity in Ischemia‐Free Versus Conventional Liver Transplantation

Advanced Science, EarlyView.
This study investigates how ischemia‐free liver transplantation (IFLT) shapes both local and systemic immune responses compared with conventional liver transplantation (CLT). Our findings demonstrate that IFLT confers significant immunological protection by attenuating the STAT3‐HIF‐1α axis and enhancing the Heme‐HMOX1 pathway, two regulatory networks ...
Tao Luo, Shuai He, Shirui Chen, Dongmei Ye, Shibo Zhang, Di Liu, Dawei Zou, Linhe Wang, Huadi Chen, Jinghong Xu, Huanjie Liu, Ruiting Liu, Xi Tan, Yitong Wang, Jiayi Zeng, Runbing Mo, Yuexin Li, Yuyi Zhang, Tanyiyang Ruan, Tielong Wang, Zehua Jia, Yu Jia, Tongdi Fang, Yimou Lin, Xiaorui Liu, Yunhua Tang, Maogen Chen, Qiang Zhao, Anbin Hu, Weiqiang Ju, Yi Ma, Dongping Wang, Xiaofeng Zhu, Schlegel Andrea, Yuan Zhai, Kwan Man, Tullius G. Stefan, Yifang Gao, Jinxin Bei, Xiaoshun He, Zhiyong Guo   +40 more
wiley   +1 more source

Anti‐citrullinated protein antibodies are associated with neutrophil extracellular trap formation in rheumatoid arthritis

Journal of clinical laboratory analysis (Print), 2020
We evaluated the associations of anti‐citrullinated protein antibodies (ACPAs) and serological and cytological levels of neutrophil extracellular trap (NET) formation in rheumatoid arthritis (RA) patients.
Siyu Wu, Wanchan Peng, Xianghui Liang, Wei Wang   +3 more
semanticscholar   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Effect of Adhesion and Substrate Elasticity on Neutrophil Extracellular Trap Formation

Frontiers in Immunology, 2019
Neutrophils are the most abundant type of white blood cells. Upon stimulation, they are able to decondense and release their chromatin as neutrophil extracellular traps (NETs). This process (NETosis) is part of immune defense mechanisms but also plays an
Luise Erpenbeck, Antonia Luise Gruhn, Galina Kudryasheva, Gökhan Günay, Gökhan Günay, Daniel Meyer, Julia Busse, Elsa Neubert, Elsa Neubert, Michael P. Schön, Michael P. Schön, Florian Rehfeldt, Sebastian Kruss   +12 more
doaj   +1 more source

Peptidylarginine deiminases as drug targets in neonatal hypoxic-ischemic encephalopathy [PDF]

, 2016
Oxygen deprivation and infection are major causes of perinatal brain injury leading to cerebral palsy and other neurological disabilities. The identification of novel key factors mediating white and grey matter damage are crucial to allow better ...
Adhami, Alonso-Alconada, Azad, Baburamani, Balandraud, Balduini, Block, Bozdag, Brinkmann, Brown, Byrd, Chavanas, Chavanas, Cherian, Cherrington, Choi, Christophorou, Cotten, Cui, Culman, David, Dingley, Dixon, Douglas-Escobar, Dragunow, Dwivedi, Erny, Fan, Faulkner, Ferretti, Ferriero, Fox, Fricker, Garcia-Romo, Ginet, Goyal, Guerrin, Gupta, Gupta, György, Hagberg, Hagberg, Hagiwara, Horibata, Imm, Ireland, Ireland, Karlsson, Kearney, Keilhoff, Kendall, Kendall, Kessenbrock, Keunen, Kholia, Knuckley, Kopatz, Kumral, Kurinczuk, Lande, Lange, Lange, Latuga, Law, Lee, Li, Li, Li, Loos, Loos, Luo, Ma, Mallard, Mallard, Marcos, Mari, Martin, Mastronardi, McCormack, Mirza, Moelants, Moelants, Musse, Neeli, Neeli, Neher, Neher, Neniskyte, Neumann, Northington, Perlman, Pirianov, Prempunpong, Proost, Robertson, Robertson, Rocha-Ferreira, Romano-Keeler, Romero, Sharda, Sherman, Simak, Slack, Spengler, Stenberg, Stys, Subramanian, Trabocchi, U, Uria-Avellanal, Villanueva, Vossenaar, Wang, Wang, Wassink, Wei, Witalison, Wood, Wright, Wu, Wu, Wyatt, Wyatt, Yektaei-Karin, Yi, Yost, Zhu, Zhu, Zhu, Zhu, Zipfel   +130 more
core   +2 more sources

Enhanced Neutrophil Extracellular Trap Formation in Acute Pancreatitis Contributes to Disease Severity and Is Reduced by Chloroquine

Frontiers in Immunology, 2019
Background: Neutrophil extracellular traps (NETs) are generated when activated neutrophils, driven by PAD4, release their DNA, histones, HMGB1, and other intracellular granule components.
P. Murthy, A. Singhi, M. Ross, P. Loughran, P. Paragomi, G. Papachristou, D. Whitcomb, A. Zureikat, M. Lotze, Herbert J. Zeh, III, B. Boone   +10 more
semanticscholar   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils and basophils but not in mononuclear cells

Frontiers in Immunology, 2012
Neutrophil extracellular traps (NETs) are fibers of extracellular DNA released from neutrophils due to overwhelming phagocytic stimuli. The function of NETs is to trap and kill microbes to avoid spreading of potential pathogens.
Christine eSchorn, Christina eJanko, Melanie eLatzko, Ricardo eChaurio, Georg eSchett, Martin eHerrmann   +5 more
doaj   +1 more source

Intrinsically Distinct Role of Neutrophil Extracellular Trap Formation in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Compared to Systemic Lupus Erythematosus

Arthritis & Rheumatology, 2019
Different studies have demonstrated that neutrophil extracellular traps (NETs) may be involved in the pathophysiology of both antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) and systemic lupus erythematosus (SLE).
Laura S. Dam, T. Kraaij, S. Kamerling, J. Bakker, U. Scherer, T. Rabelink, C. Kooten, Y. Teng   +7 more
semanticscholar   +1 more source