Results 271 to 280 of about 50,090 (336)

A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation. [PDF]

BMC Biol
Karasu E, Halbgebauer R, Schütte L, Greven J, Bläsius FM, Zeller J, Winninger O, Braig D, Messerer DAC, Berger B, Feuerstein H, Schultze A, Peter K, Knippschild U, Horst K, Hildebrand F, Eisenhardt SU, Huber-Lang M.   +17 more
europepmc   +1 more source

Club Cells in Nasal Epithelial Repair: Insights From an IL‐13‐Induced Inflammatory Model

Allergy, EarlyView.
Four inflammatory endotypes of CRSwNP, defined by eosinophil and neutrophil infiltration, show distinct patterns of basal, club, ciliated, and goblet cell expression in nasal epithelium. Using an ALI‐HNECs model, we demonstrate that IL‐13 impairs mucociliary function by promoting club‐to‐goblet cell differentiation while inhibiting club‐to‐ciliated ...
Zhi‐Qun Huang, Jing Liu, Jing Ye, Li‐Ying Sun, Hsiao Hui Ong, Yang Peng, Bing‐Qi Lin, Jun‐Hao Tu, Ke‐Shuang Wang, Yi‐Shan Xiong, Qing Luo, Mark Thong, Yu Xu, De‐Yun Wang   +13 more
wiley   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

Chromatin changes associated with neutrophil extracellular trap formation in whole blood reflect complex immune signaling. [PDF]

Front Immunol
Cayford J, Atteberry B, Singh-Taylor A, Retter A, Berman BP, Kelly TK.   +5 more
europepmc   +1 more source

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Lactate-induced macrophage HMGB1 lactylation promotes neutrophil extracellular trap formation in sepsis-associated acute kidney injury. [PDF]

Cell Biol Toxicol
Wei S, Dai Z, Wu L, Xiang Z, Yang X, Jiang L, Du Z.   +6 more
europepmc   +1 more source

Contact Activation Is Alleviated by Testosterone Replacement Therapy in Klinefelter Syndrome: Evidence of Hormonal and Metabolic Modulation

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome is associated with a markedly increased risk of venous thrombosis. While hypogonadism and metabolic dysfunction are known contributors, the role of the contact activation system in Klinefelter syndrome remains unexplored.
Simon Chang, Claus H. Gravholt, Anne Skakkebæk, Anna‐Marie Bloch Münster, Yaseelan Palarasah   +4 more
wiley   +1 more source

CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis. [PDF]

Inflammation
Lu Y, Wu H, Luo Y, Xia W, Sun D, Chen R, Miao Z, Zhang W, Yu Y, Wen A.   +9 more
europepmc   +1 more source

Optimizing Prolonged (6 h) Normothermic Machine Perfusion of Donor Kidneys (PROPER Study)

Artificial Organs, EarlyView.
Prolonged ex situ normothermic machine perfusion of donor kidneys up to 6 h is feasible, maintaining viability and histological integrity. Key protocol optimizations include fresh red blood cells, albumin supplementation, and urine recirculation—laying the groundwork for assessment and potential pretransplant interventions in future clinical trials ...
Asel S. Arykbaeva, Veerle A. Lantinga, L. Leonie van Leeuwen, Marten Engelse, Ton J. Rabelink, Jesper Kers, Jason B. Doppenberg, Volkert A. L. Huurman, Robert A. Pol, Robert C. Minnee, Henri G. D. Leuvenink, Rutger J. Ploeg, Cyril Moers, Dorottya K. de Vries, Ian P. J. Alwayn   +14 more
wiley   +1 more source

Bacteroides Fragilis-Derived Outer Membrane Vesicles Deliver MiR-5119 and Alleviate Colitis by Targeting PD-L1 to Inhibit GSDMD-Mediated Neutrophil Extracellular Trap Formation. [PDF]

Adv Sci (Weinh)
Yang Y, Yang L, Yang Y, Deng H, Su S, Xia Y, Su J, Liu Y, Wu J, Zhang J, Liao Y, Wang L.   +11 more
europepmc   +1 more source