Results 1 to 10 of about 95,572 (181)

Pulmonary fibroblast-derived stem cell factor promotes neutrophilic asthma by augmenting IL-17A production from ILC3s. [PDF]

J Clin Invest
Group 3 innate lymphoid cells (ILC3s) have emerged as an important player in the pathogenesis of neutrophilic asthma. However, the regulatory mechanism supporting ILC3 responses in the lung remains largely unclear.
Shao JS, Lai AC, Huang WC, Wu KC, Chi PY, Chang YM, Chang YJ.   +6 more
europepmc   +2 more sources

Allergens abrogate antiinflammatory DNA effects and unmask macrophage-driven neutrophilic asthma via ILC2/STING/TNF-α signaling. [PDF]

J Clin Invest
The mechanisms of neutrophilic and mixed neutrophilic-eosinophilic asthma are poorly understood. We found that extracellular DNA and nucleosomes (Nucs) were elevated in the airways of patients with neutrophilic-eosinophilic asthma and correlated with ...
Sripada A, Verma D, Varma R, Sirohi K, Kwiat C, Pathria M, Verma M, Sahu A, Guntur V, Manka L, Vestal B, Moore C, Martin RJ, Gorska MM, Cambier J, Getahun A, Alam R.   +16 more
europepmc   +2 more sources

The MFGE8/integrin β3 axis mitigates experimental neutrophilic asthma by suppressing NLRP3-Caspase-1 pathway-mediated NETosis. [PDF]

Respir Res
Background Neutrophilic asthma, characterized by the relative accumulation of neutrophils in the airways, constitutes a distinct endotype of asthma resistant to corticosteroid and associated with severe and uncontrolled cases. Milk fat globule-EGF factor
Wang S, Kun T, Tian Z, Huang M, Fan Y, Li B, Zheng H, Xu R, Wang M, Zhao J, Xie J.   +10 more
europepmc   +2 more sources

Catalase-encapsulated matrix metalloproteinase-9 responsive nanogels for modulation of inflammatory response and treatment of neutrophilic asthma. [PDF]

J Nanobiotechnology
Asthma is a chronic disease with typical pathological features such as airflow limitation, airway inflammation and remodeling. Of these, neutrophilic asthma is considered to be the more severe and corticosteroid-resistant subtype of asthma.
Guo X, Zuo X, Zheng W, Zhao D, Dong C, Zou Z, Shen Y, Xu C, He C, Wang F.   +9 more
europepmc   +2 more sources

Microbial ligand costimulation drives neutrophilic steroid-refractory asthma [PDF]

, 2015
Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. This research was also supported, in part, by National Institutes of Health GM53522 and GM083016 to DLW. KF and BNL are funded by the Fonds
AT Nathan, B Schaub, BA Fallert, Bart N. Lambrecht, Bernhard Ryffel, Beth A. Fallert Junecko, BN Lambrecht, BN Lambrecht, BN Lambrecht, BR O'Driscoll, C Braun-Fahrlander, CE Reed, David L. Williams, DC Newcomb, EC Cates, F Gerosa, F Kirstein, Frank Brombacher, Frank Kirstein, G Trinchieri, GD Brown, Gordon D. Brown, GP Anderson, Graeme Murray, H Hammad, HE Ensley, HS Goodridge, I Agache, J Chakir, J Douwes, J Thorn, J Zhao, Jay K. Kolls, JB Allard, JH Bonlokke, JL Simpson, Kaat Fierens, KM Dennehy, KM Dennehy, Kong Chen, L Dong, L McKinley, LG Gregory, LK Fogli, LM Lilly, M Kudo, M Laan, M Plantinga, M Rosas, N Pearce, NN Jarjour, PC Porter, Pierre Redelinghuys, PJ Barnes, R Rylander, RA Drummond, RA Martin, RA Mintz-Cole, RA Mintz-Cole, Rebecca A. Drummond, RH Wilson, S Ano, S Saad-El-Din Bessa, Sabelo Hadebe, Sara Sajaniemi, SC Cheng, SC Eisenbarth, Simon Vautier, Todd A. Reinhart, W Eder, WC Moore, ZZ Pan   +71 more
core   +14 more sources

Histopathology of vasculitis: Classification, controversies, and concepts

Indian Journal of Dermatopathology and Diagnostic Dermatology, 2022
Vasculitis comprises a diverse group of disorders with varying clinical, histopathological, and immunofluorescence findings arising due to an array of underlying pathogenic mechanisms.
Venkataram Mysore, Anuradha Jindal
doaj   +1 more source

Comparison of the respiratory bacterial microbiome in cats with feline asthma and chronic bronchitis

Frontiers in Veterinary Science, 2023
ObjectivesWhile feline chronic bronchitis (CB) is known as neutrophilic bronchial inflammation (NI), feline asthma (FA) is defined as an eosinophilic airway inflammation (EI).
Melanie Werner, Melanie Werner, Jasmin Weeger, Lina Hörner-Schmid, Karin Weber, Jelena Palić, Jonathan Shih, Jan S. Suchodolski, Rachel Pilla, Bianka Schulz   +9 more
doaj   +1 more source

Neutrophils and Asthma

Diagnostics, 2022
Although eosinophilic inflammation is characteristic of asthma pathogenesis, neutrophilic inflammation is also marked, and eosinophils and neutrophils can coexist in some cases. Based on the proportion of sputum cell differentiation, asthma is classified
Akira Yamasaki, Ryota Okazaki, Tomoya Harada   +2 more
doaj   +1 more source

Leukotriene B₄ Receptor 2 Mediates the Production of G-CSF That Plays a Critical Role in Steroid-Resistant Neutrophilic Airway Inflammation

Biomedicines, 2022
Granulocyte colony-stimulating factor (G-CSF) has been suggested to be closely associated with neutrophilic asthma pathogenesis. However, little is known about the factors regulating the production of G-CSF in neutrophilic asthma.
Dong-Wook Kwak, Donghwan Park, Jae-Hong Kim   +2 more
doaj   +1 more source

The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis [PDF]

, 2010
Background: Acute generalized exanthematous pustulosis (AGEP) represents a severe, acute, pustular skin reaction that is most often induced by drugs. AGEP can be difficult to differentiate from generalized pustular psoriasis (GPP) both clinically and ...
Austin, Baker, Beylot, Beylot, Britschgi, Burrows, Farber, Friedman, Guevara-Gutierrez, Horn, Iizuka, Kardaun, Katz, Keller, Kingery, Macmillan, Mobini, Muller, Naldi, Roujeau, Roujeau, Schaefer, Schmid, Shelley, Shelley, Sidoroff, Sidoroff, Smith, Spencer, Staughton, Terui, Weedon, Weedon, Yawalkar, Zelickson   +34 more
core   +8 more sources