Results 11 to 20 of about 123,459 (378)
La Revue de Médecine Interne, 2022 Neutrophilic dermatoses (ND) are a group of inflammatory skin conditions characterized by a neutrophilic infiltrate on histopathology with no evidence of infection. ND are classified based upon the localization of neutrophils within the skin and clinical features.
Delaleu, Jeremie +15 more
openaire +3 more sources
The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma
Respiratory Research, 2020 Asthma is a complex heterogeneous disease. The neutrophilic subtypes of asthma are described as persistent, more severe and corticosteroid-resistant, with higher hospitalization and mortality rates, which seriously affect the lives of asthmatic patients.
Jing Zhang +11 more
doaj +2 more sources
MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome-mediated pyroptosis through the inhibition of the TLR4/MyD88/NF-κB pathway [PDF]
Respiratory Research, 2023 Background Neutrophilic airway inflammation is a challenge in asthma management and is associated with poor patient prognosis. Mucin 1 (MUC1), which contains a cytoplasmic tail (MUC1-CT), has been found to mediate glucocorticoid sensitivity in asthma ...
Lu Liu +7 more
openalex +2 more sources
Respiratory Research, 2020 Background Neutrophilic subtype asthma occurs in approximately 15–25% of the asthma cases and is associated with severe airflow obstruction, corticosteroid resistance.
Wenjuan Xu +3 more
doaj +2 more sources
Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma [PDF]
Thorax, 2022 Background Severe neutrophilic asthma is resistant to treatment with glucocorticoids. The immunomodulatory protein macrophage migration inhibitory factor (MIF) promotes neutrophil recruitment to the lung and antagonises responses to glucocorticoids.
Venkata Sita Rama Raju Allam +16 more
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Microbial ligand costimulation drives neutrophilic steroid-refractory asthma [PDF]
, 2015 Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. This research was also supported, in part, by National Institutes of Health GM53522 and GM083016 to DLW. KF and BNL are funded by the Fonds
AT Nathan +71 more
core +14 more sources
Molecular Medicine, 2023 Background Obesity-related asthma is a kind of nonallergic asthma with excessive neutrophil infiltration in the airways. However, the underlying mechanisms have been poorly elucidated.
Yang Wang, Rongjun Wan, Chengping Hu
semanticscholar +1 more source
Luteolin alleviated neutrophilic asthma by inhibiting IL-36γ secretion-mediated MAPK pathways
Pharmaceutical Biology, 2023 Context Luteolin can affect multiple biological functions, such as anti-inflammatory, antioxidant and immune enhancement processes. Luteolin can inhibit inflammation of T2-high asthma, but its role in neutrophilic asthma has been insufficently studied ...
X. Qiao +9 more
semanticscholar +1 more source
Allergy. European Journal of Allergy and Clinical Immunology, 2023 Neutrophil migration into the airways is a key process in neutrophilic asthma. Developmental endothelial locus‐1 (DEL‐1), an extracellular matrix protein, is a neutrophil adhesion inhibitor that attenuates neutrophilic inflammation.
M. Jia +12 more
semanticscholar +1 more source
Neutrophilic dermatoses – Pathomechanistic concepts and therapeutic developments
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2023 Neutrophilic dermatoses are a group of clinically heterogeneous diseases characterized by infiltration of neutrophils in the affected tissue. Skin symptoms comprise a spectrum of wheals, papules, plaques, pustules, nodules and ulcerations often in ...
Hanna Bonnekoh, L. Erpenbeck
semanticscholar +1 more source