Results 51 to 60 of about 123,459 (378)

Correlation between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation–Antioxidant Defense System in Gastric Cancer Associated with Helicobacter pylori Infection

Biomedicines, 2023
Aim. To study the processes of lipid peroxidation and the activity of antioxidant defense enzymes depending on the chemiluminescent activity of neutrophilic granulocytes in patients with gastric cancer associated with H.
Olga Valentinovna Smirnova, Alexander Alexandrovich Sinyakov, Eduard Vilyamovich Kasparov   +2 more
doaj   +1 more source

Evaluation of Functional Condition of Respiratory Muscles of Patients with a Complicated Bronchial Asthma Pathology and Chronic Obstructive Pulmonary Diseases [PDF]

, 2017
The aim of the research was to study the functional state of respiratory muscles and neuro-respiratory drive in patients with a combined pathology of bronchial asthma and chronic obstructive pulmonary disease.The functional condition of the respiratory ...
Feschenko, Y. (Yuriy), Nazarenko, K. (Ksenia)   +1 more
core   +2 more sources

Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease. [PDF]

PLoS Pathogens, 2011
A subset of patients with stable asthma has prominent neutrophilic and reduced eosinophilic inflammation, which is associated with attenuated airways hyper-responsiveness (AHR).
Ama-Tawiah Essilfie, Jodie L Simpson, Jay C Horvat, Julie A Preston, Margaret L Dunkley, Paul S Foster, Peter G Gibson, Philip M Hansbro   +7 more
doaj   +1 more source

Airway monocyte modulation relates to tumour necrosis factor dysregulation in neutrophilic asthma

ERJ Open Research, 2021
Background Dysregulation of tumour necrosis factor-α (TNF-α) signalling is implicated in neutrophilic asthma. TNF-α signalling involves membrane-bound and soluble ligand (TNF-α) and receptors (TNFRs); however, little is known about how these proteins are
Natalie M. Niessen, Peter G. Gibson, Jodie L. Simpson, Hayley A. Scott, Katherine J. Baines, Michael Fricker   +5 more
doaj   +1 more source

Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-κB pathway and secrete chemokines

Aging, 2020
Neutrophilic asthma (NA) is a distinct airway inflammation disease with prominent neutrophil infiltration. The role played by neutrophil extracellular traps (NETs) in NA, however, is quite unclear.
Rongjun Wan, Juan Jiang, Chengping Hu, Xi Chen, Cen Chen, Bingrong Zhao, Xinyue Hu, Zhiyuan Zheng, Yuanyuan Li   +8 more
semanticscholar   +1 more source

Discovery of a First‐in‐Class Covalent Allosteric SHP1 Inhibitor with Immunotherapeutic Activity

Angewandte Chemie, EarlyView.
A covalent allosteric inhibitor M029 was discovered for SHP1, a novel target for immunotherapy. M029 binds to a cryptic Cys remote from the active site, exhibits robust target engagement, and blocks tumor progression by stimulating antitumor immune response.
Zihan Qu, Frederick Nguele Meke, Zheng Zhang, Aaron D. Krabill, Christine S. Muli, Brenson A. Jassim, Jiajun Dong, Quyen D. Nguyen, Yunpeng Bai, Jinyue Li, Yiming Miao, Bardia Asadi, Levi M. Johnson, Jinmin Miao, Darci J. Trader, W. Andy Tao, Zhong‐Yin Zhang   +16 more
wiley   +2 more sources

Neuropilin‐2 regulates airway inflammation in a neutrophilic asthma model

Immunity, Inflammation and Disease, 2022
Background Asthma is a heterogenous disease that can be classified into eosinophilic (type 2‐high) and noneosinophilic (type 2‐low) endotypes. The type 2‐low endotype of asthma can be characterized by the presence of neutrophilic airway inflammation that
Robert M. Immormino, Corey M. Jania, Stephen L. Tilley, Timothy P. Moran   +3 more
doaj   +1 more source

Cytological Findings of 140 Bile Samples from Dogs and Cats and Associated Clinical Pathological Data [PDF]

, 2015
BACKGROUND: Cholecystocentesis can be part of the diagnostic workup of hepatobiliary disease in small animals, but literature on cytological evaluation of bile is scant.
Boomkens, Brain, Braun, Center, Clark, Crews, Flatland, Geigy, Kook, Lawrence, Neel, Ramery, Savary-Bataille, Sung, Voros, Wagner, Weiss   +16 more
core   +2 more sources

Granzyme K+CD8+ T cells interact with fibroblasts to promote neutrophilic inflammation in nasal polyps

Nature Communications
Sophisticated interactions between stromal and immune cells play crucial roles in various biological and pathological processes. In chronic rhinosinusitis with nasal polyps (CRSwNP), the upper airway inflammation in many patients is driven by TH2, ILC2 ...
Cui-Lian Guo, Chong-Shu Wang, Zhi-chao Wang, Fei-Fan Liu, Lin Liu, Yang Yang, Xia Li, Bei Guo, Ruo-Yu Lu, B. Liao, Jin-xin Liu, Hai Wang, Jia Song, Yin Yao, Li-Ping Zhu, Di Yu, Zheng Liu   +16 more
semanticscholar   +1 more source

Acneiform dermatoses [PDF]

, 1998
Acneiform dermatoses are follicular eruptions. The initial lesion is inflammatory, usually a papule or pustule. Comedones are later secondary lesions, a sequel to encapsulation and healing of the primary abscess.
Jansen, Thomas, Plewig, G.
core   +1 more source