Results 1 to 10 of about 1,027,405 (258)

SPP1 promotes lymph node metastasis and malignant progression of head and neck squamous cell carcinoma by activating FAK-AKT signaling pathway

World Journal of Surgical Oncology
Background Lymph node metastasis is a critical determinant of poor prognosis in head and neck squamous cell carcinoma (HNSCC). Secreted phosphoprotein 1 (SPP1) has been implicated in the progression of multiple malignancies; however, its clinical ...
Jingyan Li, Min Pan, Mengna Wang, Tianhao Wu, Youlan Zhang, Zhihai Wang, Quan Zeng   +6 more
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Spatial Eosinophil Phenotypes as Immunopathogenic Determinants in Inflammatory Diseases

Cells
Eosinophils are increasingly recognized as adaptable immune cells that exhibit diverse phenotypes and effector functions across different tissues and disease states.
Jonas S. Erjefält
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Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science
This study employed an imaging‐decoding strategy to quantitatively characterize intratumoral heterogeneity (ITH) in patients with head and neck squamous cell carcinoma (HNSCC), and further evaluated the capacity of the imaging‐based ITH score in ...
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
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Anti-asthmatic miR-224-5p inhibits the FHL1/MAPK pathway to repress airway smooth muscle cell proliferation in a murine model of asthma-like airway inflammation

Allergy, Asthma & Clinical Immunology, 2022
Background The proliferation of airway smooth muscle cells (ASMCs) contributes to the contractility and inflammation in the pathophysiology of asthma. This intrigued us to clarify the effect of microRNA (miR)-224-5p on biological characteristics of ASMCs
Zhifang Zhuang, Yanjuan Zhou, Jiao Xu, Leying Pan   +3 more
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Proanthocyanidin from Grape Seed Extract Inhibits Airway Inflammation and Remodeling in a Murine Model of Chronic Asthma

Natural Product Communications, 2015
Asthma is characterized by airway inflammation and airway remodeling. Our previous study revealed that grape seed proanthocyanidin extract (GSPE) could inhibit asthmatic airway inflammation and airway hyper-responsiveness by down-regulation of inducible ...
Dan-Yang Zhou, Su-Rong Fang, Chun-Fang Zou, Qian Zhang, Wei Gu   +4 more
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Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease

Respiratory Research, 2022
Background Airway remodeling is a significant contributor to impaired lung function in chronic allergic airway disease. Currently, no therapy exists that is capable of targeting these structural changes and the consequent loss of function. In the context
Rebecca Bignold, Bushra Shammout, Jessica E. Rowley, Mariaelena Repici, John Simms, Jill R. Johnson   +5 more
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Melatonin: a promising therapy to combat type 2 airway inflammation via MT1-Sirt1 pathway

Frontiers in Pharmacology
BackgroundsType 2 asthma is characterized by airway inflammation, mucus hypersecretion, and remodeling, and circadian rhythm dysregulation is implicated in its pathogenesis.
Zhe Zhang, Jie Jiang, Guilian Chen, Xiuqin Zhang, Jipeng Wang, Baolan Wang   +5 more
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Nontypeable Haemophilus influenzae-Induced MyD88 Short Expression Is Regulated by Positive IKKβ and CREB Pathways and Negative ERK1/2 Pathway.

PLoS ONE, 2015
Airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) are characterized by excessive inflammation and are exacerbated by nontypeable Haemophilus influenzae (NTHi).
Carla S Andrews, Masanori Miyata, Seiko Susuki-Miyata, Byung-Cheol Lee, Kensei Komatsu, Jian-Dong Li   +5 more
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Bacillus Calmette-Guerin alleviates airway inflammation and remodeling by preventing TGF-β1 induced epithelial–mesenchymal transition

Human Vaccines & Immunotherapeutics, 2017
Bacillus Calmette-Guerin (BCG) is a potent agent for the prevention of tuberculosis. Current studies have regarded BCG as an immunomodulator. However, there is little information on whether it can be used to inhibit airway inflammation and airway ...
Xinrui Tian, Xinli Tian, Rujie Huo, Qin Chang, Guoping Zheng, Yan Du, Yan Chen, Bo Niu   +7 more
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Possible involvement of acetylcholine-mediated inflammation in airway diseases

Allergology International, 2018
Inhaled bronchodilator treatment with a long acting muscarinic antagonist (LAMA) reduces symptoms and the risk of exacerbations in COPD and asthma. However, increasing evidence from cell culture and animal studies suggests that anti-muscarinic drugs ...
Akira Koarai, Masakazu Ichinose
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