Results 1 to 10 of about 162,572 (266)

Melatonin: a promising therapy to combat type 2 airway inflammation via MT1-Sirt1 pathway [PDF]

Frontiers in Pharmacology
BackgroundsType 2 asthma is characterized by airway inflammation, mucus hypersecretion, and remodeling, and circadian rhythm dysregulation is implicated in its pathogenesis.
Zhe Zhang, Jie Jiang, Guilian Chen, Xiuqin Zhang, Jipeng Wang, Baolan Wang   +5 more
doaj   +2 more sources

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling [PDF]

Advanced Science
Airway inflammation and remodeling are cardinal features of asthma pathogenesis. Genome‐wide association studies have shown that several SNPs of KCNJ2, a member of the inwardly rectifying potassium channel family, are associated with asthma in patients ...
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
doaj   +2 more sources

Alpha7 nicotinic acetylcholine receptor activation attenuates allergic airway inflammation and is associated with heme oxygenase-1 induction [PDF]

Frontiers in Immunology
BackgroundActivation of the α7 nicotinic acetylcholine receptor (α7nAChR) exerts anti-inflammatory effects; however, its role in allergic airway inflammation remains poorly understood. This study investigated how GTS-21 treatment, consistent with α7nAChR
Jun Iriki, Jun Iriki, Susumu Fukahori, Yasushi Obase, Yasushi Obase, Yasuna Nakamura, Ryusuke Umene, Ryusuke Umene, Chia-Hsien Wu, Yuri Yamada, Yuri Yamada, Shinnosuke Takemoto, Takahiro Takazono, Takahiro Takazono, Noriho Sakamoto, Chizu Fukushima, Chizu Fukushima, Tomoya Nishino, Hiroshi Mukae, Hiroshi Mukae, Tsuyoshi Inoue   +20 more
doaj   +2 more sources

Mucosal cryobiopsies: a new method for studying airway pathology in asthma

ERJ Open Research, 2022
Background In vivo studies of airway pathology in obstructive lung disease are limited by poor quality of specimens obtained with forceps. Obtainment of cryobiopsies has increased diagnostic yield in cancer and interstitial lung disease but has not been ...
Morten Hvidtfeldt, Asger Sverrild, Alexis Pulga, Laurits Frøssing, Alexander Silberbrandt, Caroline Sanden, Carl Magnus Clausson, Daisy Bornesund, Jonas Erjefält, Celeste Porsbjerg   +9 more
doaj   +1 more source

Dynamically upregulated mast cell CPA3 patterns in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

Frontiers in Immunology, 2022
BackgroundThe mast cell-specific metalloprotease CPA3 has been given important roles in lung tissue homeostasis and disease pathogenesis. However, the dynamics and spatial distribution of mast cell CPA3 expression in lung diseases remain unknown ...
Premkumar Siddhuraj, Jimmie Jönsson, Manar Alyamani, Pavan Prabhala, Mattias Magnusson, Sandra Lindstedt, Jonas S. Erjefält, Jonas S. Erjefält   +7 more
doaj   +1 more source

Luteolin peracetate and gossypolone inhibit immune complex-mediated neutrophil activation in vitro and dermal-epidermal separation in an ex vivo model of epidermolysis bullosa acquisita

Frontiers in Immunology, 2023
IntroductionNatural products have been shown to an important source of therapeutics for human disease. In this study, we aimed to identify natural compounds as potential therapeutics for epidermolysis bullosa acquisita (EBA), an autoimmune disease caused
Kai Yang, Junping Yin, Xiaoyang Yue, Katja Bieber, Gabriela Riemekasten, Ralf J. Ludwig, Frank Petersen, Xinhua Yu   +7 more
doaj   +1 more source

Type II alveolar epithelial cell aryl hydrocarbon receptor protects against allergic airway inflammation through controlling cell autophagy

Frontiers in Immunology, 2022
RationaleAryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, has been considered as an important regulator for immune diseases. We have previously shown that AhR protects against allergic airway inflammation.
Ji Wang, Ji Wang, Ji Wang, Yilin Zhao, Yilin Zhao, Xin Zhang, Xin Zhang, Wei Tu, Wei Tu, Rongjun Wan, Rongjun Wan, Yingchun Shen, Yan Zhang, Yan Zhang, Ruchik Trivedi, Peisong Gao   +15 more
doaj   +1 more source

Airway epithelial STAT3 inhibits allergic inflammation via upregulation of stearoyl-CoA desaturase 1

Allergology International, 2022
Background: Airway epithelial cells (AECs) play a crucial role in the induction and development of allergic inflammation through the development and activation of immune cells, including Th2 cells and ILC2s.
Nozomi Nishimura, Masaya Yokota, Shunjiro Kurihara, Arifumi Iwata, Takahiro Kageyama, Takashi Ito, Aiko Saku, Yuko Maezawa, Koichi Hirose, Hiroshi Nakajima   +9 more
doaj   +1 more source

Airway Inflammation and Airway Hyperresponsiveness [PDF]

, 2021
Airway inflammation is a complex inflammatory process of airways involving the contribution of various cells, recruited and activated in asthmatic conditions, and the mediators released by them. However, major components contributing to this inflammation are eosinophils, mast cells, and lymphocytes.
Sheikh Rayees, Inshah Din
openaire   +1 more source

Leukotrienes and airway inflammation [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2011
Asthma is a common chronic inflammatory disease of the airways characterized by airway obstruction and hyperresponsiveness. Leukotrienes (LTs) are lipid mediators that contribute to many aspects of asthma pathogenesis. As the LT pathway is relatively steroid-resistant, its blockade by alternative strategies is a desirable component of asthma management.
Katsuhide, Okunishi, Marc, Peters-Golden
openaire   +2 more sources