Results 11 to 20 of about 1,027,405 (258)

Targeting TSLP With shRNA Alleviates Airway Inflammation and Decreases Epithelial CCL17 in a Murine Model of Asthma

Molecular Therapy: Nucleic Acids, 2016
Airway epithelium defends the invasion from microorganisms and regulates immune responses in allergic asthma. Thymic stromal lymphopoietin (TSLP) from inflamed epithelium promotes maturation of dendritic cells (DCs) to prime Th2 responses via CCL17 ...
Yi-Lien Chen, Bor-Luen Chiang
doaj   +2 more sources

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling [PDF]

Advanced Science
Airway inflammation and remodeling are cardinal features of asthma pathogenesis. Genome‐wide association studies have shown that several SNPs of KCNJ2, a member of the inwardly rectifying potassium channel family, are associated with asthma in patients ...
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
doaj   +2 more sources

ETB receptor deficiency amplifies allergic airway inflammation and hyperresponsiveness [PDF]

ERJ Open Research
Background Endothelin-1 (ET-1) is a proinflammatory mediator that plays a crucial role in regulating airway tone by activating G protein-coupled endothelin receptors A (ETA) and B (ETB).
Christoph Tabeling, Carla R. González Calera, Birgitt Gutbier, Laura Michalick, Carl-Friedrich Hocher, Katharina Ahrens, Jan Naujoks, Julia Herbert, Lynn J. Savic, Matthias Felten, Bastian Opitz, Hartwig Schütte, Wolfgang M. Kuebler, Thomas Tschernig, Berthold Hocher, Martin Witzenrath   +15 more
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The role of airway infection in chronic obstructive pulmonary disease [PDF]

, 2006
PhDThis. thesis examines the role of respiratory bacterial and viral infection in the natural history of Chronic Obstructive Pulmonary Disease. The rationale for this study is basedu pon previous data demonstratingt hat airway bacterial colonisationi s
Wilkinson, Thomas Michael Alan
core   +4 more sources

Mucosal cryobiopsies: a new method for studying airway pathology in asthma

ERJ Open Research, 2022
Background In vivo studies of airway pathology in obstructive lung disease are limited by poor quality of specimens obtained with forceps. Obtainment of cryobiopsies has increased diagnostic yield in cancer and interstitial lung disease but has not been ...
Morten Hvidtfeldt, Asger Sverrild, Alexis Pulga, Laurits Frøssing, Alexander Silberbrandt, Caroline Sanden, Carl Magnus Clausson, Daisy Bornesund, Jonas Erjefält, Celeste Porsbjerg   +9 more
doaj   +1 more source

Dynamically upregulated mast cell CPA3 patterns in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis

Frontiers in Immunology, 2022
BackgroundThe mast cell-specific metalloprotease CPA3 has been given important roles in lung tissue homeostasis and disease pathogenesis. However, the dynamics and spatial distribution of mast cell CPA3 expression in lung diseases remain unknown ...
Premkumar Siddhuraj, Jimmie Jönsson, Manar Alyamani, Pavan Prabhala, Mattias Magnusson, Sandra Lindstedt, Jonas S. Erjefält, Jonas S. Erjefält   +7 more
doaj   +1 more source

Effects of qufeng xuanfei formula in guinea pig model of airway hyperergy

Pakistan Journal of Pharmaceutical Sciences, 2023
This work aimed to clarify the potential regulating effects of Qufeng Xuanfei formula (QFXF) on airway neurogenic inflammation and its underlying target signal pathway. Guinea pig model of airway hyperergy (AHR) was used.
Kun Ji, Jian-Ling Ma, Li-Qing Shi, Liang-Min Wang, Niu-Niu Li, Shang-Juan Dong, Bin Lin, Li-Yun Wang, Shao-Hui Wen   +8 more
doaj   +1 more source

Luteolin peracetate and gossypolone inhibit immune complex-mediated neutrophil activation in vitro and dermal-epidermal separation in an ex vivo model of epidermolysis bullosa acquisita

Frontiers in Immunology, 2023
IntroductionNatural products have been shown to an important source of therapeutics for human disease. In this study, we aimed to identify natural compounds as potential therapeutics for epidermolysis bullosa acquisita (EBA), an autoimmune disease caused
Kai Yang, Junping Yin, Xiaoyang Yue, Katja Bieber, Gabriela Riemekasten, Ralf J. Ludwig, Frank Petersen, Xinhua Yu   +7 more
doaj   +1 more source

Type II alveolar epithelial cell aryl hydrocarbon receptor protects against allergic airway inflammation through controlling cell autophagy

Frontiers in Immunology, 2022
RationaleAryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, has been considered as an important regulator for immune diseases. We have previously shown that AhR protects against allergic airway inflammation.
Ji Wang, Ji Wang, Ji Wang, Yilin Zhao, Yilin Zhao, Xin Zhang, Xin Zhang, Wei Tu, Wei Tu, Rongjun Wan, Rongjun Wan, Yingchun Shen, Yan Zhang, Yan Zhang, Ruchik Trivedi, Peisong Gao   +15 more
doaj   +1 more source

Airway epithelial STAT3 inhibits allergic inflammation via upregulation of stearoyl-CoA desaturase 1

Allergology International, 2022
Background: Airway epithelial cells (AECs) play a crucial role in the induction and development of allergic inflammation through the development and activation of immune cells, including Th2 cells and ILC2s.
Nozomi Nishimura, Masaya Yokota, Shunjiro Kurihara, Arifumi Iwata, Takahiro Kageyama, Takashi Ito, Aiko Saku, Yuko Maezawa, Koichi Hirose, Hiroshi Nakajima   +9 more
doaj   +1 more source