Results 11 to 20 of about 959,395 (302)
Molecular Therapy: Nucleic Acids, 2016 Airway epithelium defends the invasion from microorganisms and regulates immune responses in allergic asthma. Thymic stromal lymphopoietin (TSLP) from inflamed epithelium promotes maturation of dendritic cells (DCs) to prime Th2 responses via CCL17 ...
Yi-Lien Chen, Bor-Luen Chiang
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The role of airway infection in chronic obstructive pulmonary disease [PDF]
, 2006 PhDThis. thesis examines the role of respiratory bacterial and viral infection in the natural history of Chronic Obstructive Pulmonary Disease. The rationale for this study is basedu pon previous data demonstratingt hat airway bacterial colonisationi s
Wilkinson, Thomas Michael Alan
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Leukotrienes and airway inflammation [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2011 Asthma is a common chronic inflammatory disease of the airways characterized by airway obstruction and hyperresponsiveness. Leukotrienes (LTs) are lipid mediators that contribute to many aspects of asthma pathogenesis. As the LT pathway is relatively steroid-resistant, its blockade by alternative strategies is a desirable component of asthma management.
Katsuhide, Okunishi, Marc, Peters-Golden
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mBio, 2014 Mycoplasma pneumoniae synthesizes a novel human surfactant protein A (SP-A)-binding cytotoxin, designated community-acquired respiratory distress syndrome (CARDS) toxin, that exhibits ADP-ribosylating and vacuolating activities in mammalian cells and is ...
Sudha R. Somarajan +5 more
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Parkin Promotes Airway Inflammatory Response to Interferon Gamma
Biomedicines, 2023 Purpose: Increased type 2 interferon (i.e., IFN-γ) signaling has been shown to be involved in airway inflammation in a subset of asthma patients who often show high levels of airway neutrophilic inflammation and poor response to corticosteroid treatment.
Kris Genelyn Dimasuay +4 more
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ADP-Ribosylation of NLRP3 by
mBio, 2014 The inflammasome is a major regulator of inflammation through its activation of procaspase-1, which cleaves prointerleukin-1β (pro-IL-1β) into its mature form.
Santanu Bose +5 more
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Chronic respiratory aeroallergen exposure in mice induces epithelial-mesenchymal transition in the large airways. [PDF]
PLoS ONE, 2011 Chronic allergic asthma is characterized by Th2-polarized inflammation and leads to airway remodeling and fibrosis but the mechanisms involved are not clear.
Jill R Johnson +4 more
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Airway responses and inflammation in subjects with asthma after four days of repeated high-single-dose allergen challenge [PDF]
, 2012 Background: Both standard and low-dose allergen provocations are an established tool in asthma research to improve our understanding of the pathophysiological mechanism of allergic asthma.
Rose Markus A +17 more
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The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype [PDF]
, 2013 We previously demonstrated inhibition of ovalbumin (OVA)-induced allergic airway hyper-responsiveness in the mouse using ES-62, a phosphorylcholine-containing glycoprotein secreted by the filarial nematode, Acanthocheilonema viteae.
Al-Riyami, Lamyaa +8 more
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CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice
Frontiers in Immunology, 2020 RationaleIncreased IL-8 levels and neutrophil accumulation in the airways are common features found in patients affected by pulmonary diseases such as Asthma, Idiopathic Pulmonary Fibrosis, Influenza-A infection and COPD.
Matheus Silverio Mattos +13 more
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