Results 21 to 30 of about 162,572 (266)

High-fat diet and palmitic acid amplify airway type 2 inflammation

Frontiers in Allergy, 2023
IntroductionMetabolic dysfunction such as elevated levels of saturated fatty acids (SFA) may play a role in obese asthma, but its contribution to airway inflammation remains unclear.
Kris Genelyn Dimasuay, Bruce Berg, Niccolette Schaunaman, Fernando Holguin, Daniel Winnica, Hong Wei Chu   +5 more
doaj   +1 more source

Targeting TSLP With shRNA Alleviates Airway Inflammation and Decreases Epithelial CCL17 in a Murine Model of Asthma

Molecular Therapy: Nucleic Acids, 2016
Airway epithelium defends the invasion from microorganisms and regulates immune responses in allergic asthma. Thymic stromal lymphopoietin (TSLP) from inflamed epithelium promotes maturation of dendritic cells (DCs) to prime Th2 responses via CCL17 ...
Yi-Lien Chen, Bor-Luen Chiang
doaj   +1 more source

Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite. [PDF]

PLoS ONE, 2013
Chronic allergic asthma is characterized by Th2-typed inflammation, and contributes to airway remodeling and the deterioration of lung function. However, the initiating factor that links airway inflammation to remodeling is unknown.
Zhuang-Gui Chen, Tian-Tuo Zhang, Hong-Tao Li, Fen-Hua Chen, Xiao-Ling Zou, Jing-Zhi Ji, Hong Chen   +6 more
doaj   +1 more source

Remodelling and Inflammation in Bronchial Asthma

European Journal of Inflammation, 2003
Chronic stable asthma is characterized by inflammation of the airway wall, with abnormal accumulation of basophils, eosinophils, lymphocytes, mast cells, macrophages, dendritic cells and myofibroblasts.
G. Riccioni, N. D'Orazio, R. Della Vecchia, T. Iezzi, C. Di Ilio   +4 more
doaj   +1 more source

Spatial characteristics of neutrophils and eosinophils in conducting airway mucosa of mice with induced allergic airway inflammation

Медицинская иммунология, 2023
Daily inhaled antigens induce cellular immune response in the airways. In case of allergens, allergic airway inflammation is usually represented by eosinophils, however, neutrophil infiltration is also observed during severe asthma.
M. A. Shevchenko, D. E. Murova, E. A. Servuli   +2 more
doaj   +1 more source

Inflammation and Airway Reactivity

Experimental Lung Research, 1984
Sir John Floyer's preface to the Treatise of the Asthma, published in 1698, began as follows: Since the cure of the asthma is observed by all physicians, who have attempted the eradicating that chronical distemper, to be very difficult, and frequently unsuccessful: I may thence infer, that either the true nature of that disease is not thoroughly ...
J R, Snapper, K L, Brigham
openaire   +2 more sources

PM2.5 Induced Nasal Mucosal Barrier Dysfunction and Epithelial–Mesenchymal Transition to Promote Chronic Rhinosinusitis Through IL4I1-AhR Signaling Pathway

Toxics
Environmental pollutants like PM2.5 contribute to chronic rhinosinusitis (CRS). The aryl hydrocarbon receptor (AhR), a contaminant sensor linked to tryptophan metabolites, is regulated by IL4I.
Yue Wang, Bowen Zheng, Panhui Xiong, Yijun Liu, Longlan Shu, Yang Shen, Tao Lu, Yucheng Yang   +7 more
doaj   +1 more source

Airway Inflammation and Structural Changes in Airway Hyper-Responsiveness and Asthma: An Overview

Canadian Respiratory Journal, 1998
Asthma treatment has moved from bronchodilator therapy to an emphasis on anti-inflammatory therapy. Airway inflammation is believed to induce airway hyper-responsiveness (AHR) through the release of mediators that increase the airway response to agonists.
Louis-Philippe Boulet, Jamila Chakir, Jean Dubé, Catherine Laprise, Michel Boutet, Michel Laviolette   +5 more
doaj   +1 more source

Regulatory T cells mediated immunomodulation during asthma: a therapeutic standpoint

Journal of Translational Medicine, 2020
Asthma is an inflammatory disease of the lung airway network, which is initiated and perpetuated by allergen-specific CD4+ T cells, IgE antibodies, and a massive release of Th2 cytokines.
Mohammad Afzal Khan
doaj   +1 more source

LncRNA NEAT1 promotes epithelial–mesenchymal transition in nasal polyp cells via the miR-199-3p/PAK4 axis

Frontiers in Immunology
Background and purposeChronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent inflammatory condition marked by high recurrence and limited therapeutic efficacy.
Shuman Li, Yu Jiang, Yalan Zhang, Bowen Zheng, Chao Yuan, Yang Shen, Yi Zhao, Tao Lu, Yucheng Yang   +8 more
doaj   +1 more source