Results 21 to 30 of about 959,395 (302)

A pilot randomized clinical trial of γ-tocopherol supplementation on wood smoke–induced neutrophilic and eosinophilic airway inflammation

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Air pollutants, including particulates from wood smoke, are a significant cause of exacerbation of lung disease. γ-Tocopherol is an anti-inflammatory isoform of vitamin E that has been shown to reduce allergen-, ozone-, and endotoxin-induced ...
David B. Peden, MD, Martha Almond, RRT, Christian Brooks, BS, Carole Robinette, MS, Heather Wells, MS, Allison Burbank, MD, Michelle Hernandez, MD, Alan Hinderliter, MD, Melissa Caughey, PhD, Qing Jiang, PhD, Qianyue Wang, MS, Haolin Li, BSPH, Haibo Zhou, PhD, Neil Alexis, PhD   +13 more
doaj   +1 more source

The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer [PDF]

, 2013
Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease.
Suratt, Benjamin T., Weiss Daniel J., Laura Hoyt, Daggett, Rebecca, Alcorn John F., Poynter, ME, Daggett, R, Daggett Rebecca, Martin, Rebecca A., Lundblad Lennart K. A., Martin, RA, Daniel J. Weiss (460686), Ather Jennifer L., Lennart K. A. Lundblad (49082), Jennifer L. Ather (460682), Rebecca Daggett (460683), Alcorn, John F., Poynter, Matthew E., Hoyt Laura, Laura Hoyt (460684), John F. Alcorn (298001), Hoyt, L, Martin Rebecca A., Lennart K A Lundblad, Rebecca A Martin, Lundblad, Lennart K. A., Rebecca A. Martin (435571), Hoyt, Laura, Weiss, Daniel J., Poynter Matthew E., Rebecca Daggett, John F Alcorn, Alcorn, JF, Benjamin T Suratt, Suratt, BT, Ather, Jennifer L., Daniel J Weiss, Matthew E. Poynter (435575), Weiss, DJ, Lundblad, LKA, Jennifer L Ather, Benjamin T. Suratt (460685), Ather, JL, Chu, Hong Wei, Matthew E Poynter, Suratt Benjamin T.   +45 more
core   +2 more sources

Novel Lung Growth Strategy with Biological Therapy Targeting Airway Remodeling in Childhood Bronchial Asthma

Children, 2022
Anti-inflammatory therapy, centered on inhaled steroids, suppresses airway inflammation in asthma, reduces asthma mortality and hospitalization rates, and achieves clinical remission in many pediatric patients.
Mitsuru Tsuge, Masanori Ikeda, Hirokazu Tsukahara   +2 more
doaj   +1 more source

Urinary CC16 after challenge with dry air hyperpnoea and mannitol in recreational summer athletes [PDF]

, 2013
Airway epithelial injury is regarded as a key contributing factor to the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. The concentration of the pneumoprotein club cell (Clara cell) CC16 in urine has been found to be a non ...
Pascale Kippelen, Leena Ali, Ali, Leena, Anderson, Sandra D., Bjermer, Leif, Tufvesson, E, Bjermer, L, Tufvesson, Ellen, Ali, L, Kippelen, P, Kippelen, Pascale, Leif Bjermer, Sandra D. Anderson, Anderson, SD, Ellen Tufvesson   +14 more
core   +1 more source

Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling [PDF]

, 2005
Background: Sub- epithelial extracellular matrix deposition is a feature of asthmatic airway remodelling associated with severity of disease, decline in lung function and airway hyperresponsiveness.
Reinhardt Alistair K, Robin J McAnulty, Reinhardt, AK, McAnulty Robin J, Geoffrey J Laurent, Laurent, GJ, Laurent Geoffrey J, Bottoms, SE, Bottoms Stephen E, McAnulty, RJ, Stephen E Bottoms, Alistair K Reinhardt   +11 more
core   +2 more sources

Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells

ERJ Open Research, 2018
Viral infections predispose to the development of childhood asthma, a disease associated with increased lung mast cells (MCs). This study investigated whether viral lower respiratory tract infections (LRTIs) can already evoke a MC response during ...
Cecilia K. Andersson, Medya Shikhagaie, Michiko Mori, Amal Al-Garawi, Jennifer L. Reed, Alison A. Humbles, Robert Welliver, Thais Mauad, Leif Bjermer, Manel Jordana, Jonas S. Erjefält   +10 more
doaj   +1 more source

Role of FK506-sensitive signals in asthmatic lung inflammation

Frontiers in Immunology, 2022
Asthma is airway inflammatory diseases caused by the activation of group 2 innate lymphoid cells (ILC2s) and type 2 helper T (TH2) cells. Cysteine proteases allergen cause tissue damage to airway epithelial cells and activate ILC2-mediated type 2 airway ...
Chihiro Tomiaki, Kosuke Miyauchi, Sewon Ki, Yoshie Suzuki, Narumi Suzuki, Hiroshi Morimoto, Yohei Mukoyama, Masato Kubo, Masato Kubo   +8 more
doaj   +1 more source

Airway wall remodeling in asthma : novel mechanisms of human bronchial smooth muscle cells in the induction of angiogenesis [PDF]

, 2014
Asthma is a global major health concern and it affects estimated 300 million people. The prevalence of asthma is rising and there is no cure for asthma, only the symptoms can be controlled.
Keglowich, Laura Franziska
core   +1 more source

NETopathic Inflammation in Chronic Obstructive Pulmonary Disease and Severe Asthma

Frontiers in Immunology, 2019
Neutrophils play a central role in innate immunity, inflammation, and resolution. Unresolving neutrophilia features as a disrupted inflammatory process in the airways of patients with chronic obstructive pulmonary disease (COPD) and severe asthma.
Mohib Uddin, Mohib Uddin, Henrik Watz, Henrik Watz, Anna Malmgren, Frauke Pedersen, Frauke Pedersen, Frauke Pedersen   +7 more
doaj   +1 more source

High-fat diet and palmitic acid amplify airway type 2 inflammation

Frontiers in Allergy, 2023
IntroductionMetabolic dysfunction such as elevated levels of saturated fatty acids (SFA) may play a role in obese asthma, but its contribution to airway inflammation remains unclear.
Kris Genelyn Dimasuay, Bruce Berg, Niccolette Schaunaman, Fernando Holguin, Daniel Winnica, Hong Wei Chu   +5 more
doaj   +1 more source