Results 41 to 50 of about 959,395 (302)

LncRNA NEAT1 promotes epithelial–mesenchymal transition in nasal polyp cells via the miR-199-3p/PAK4 axis

Frontiers in Immunology
Background and purposeChronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent inflammatory condition marked by high recurrence and limited therapeutic efficacy.
Shuman Li, Yu Jiang, Yalan Zhang, Bowen Zheng, Chao Yuan, Yang Shen, Yi Zhao, Tao Lu, Yucheng Yang   +8 more
doaj   +1 more source

Human airway xenograft models of epithelial cell regeneration [PDF]

, 2000
Regeneration and restoration of the airway epithelium after mechanical, viral or bacterial injury have a determinant role in the evolution of numerous respiratory diseases such as chronic bronchitis, asthma and cystic fibrosis.
Puchelle Edith, Puchelle, Edith, Peault Bruno, Edith Puchelle, Bruno Peault, Peault, Bruno   +5 more
core   +1 more source

Airway Inflammation and Structural Changes in Airway Hyper-Responsiveness and Asthma: An Overview

Canadian Respiratory Journal, 1998
Asthma treatment has moved from bronchodilator therapy to an emphasis on anti-inflammatory therapy. Airway inflammation is believed to induce airway hyper-responsiveness (AHR) through the release of mediators that increase the airway response to agonists.
Louis-Philippe Boulet, Jamila Chakir, Jean Dubé, Catherine Laprise, Michel Boutet, Michel Laviolette   +5 more
doaj   +1 more source

Spatial characteristics of neutrophils and eosinophils in conducting airway mucosa of mice with induced allergic airway inflammation

Медицинская иммунология, 2023
Daily inhaled antigens induce cellular immune response in the airways. In case of allergens, allergic airway inflammation is usually represented by eosinophils, however, neutrophil infiltration is also observed during severe asthma.
M. A. Shevchenko, D. E. Murova, E. A. Servuli   +2 more
doaj   +1 more source

Current Insights Into Individualized Diagnosis and Treatment of Allergic Rhinitis Based on Phenotype and Endotype

World Journal of Otorhinolaryngology-Head and Neck Surgery
Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa characterized by allergen sensitization and the involvement of multiple inflammatory mediators.
Yue Gu, Long‐Lan Shu, Tao Lu, Da‐Yu Guan, Bo‐Wen Zheng, Pan‐Hui Xiong, Yang Shen, Yu‐Cheng Yang   +7 more
doaj   +1 more source

Regulatory T cells mediated immunomodulation during asthma: a therapeutic standpoint

Journal of Translational Medicine, 2020
Asthma is an inflammatory disease of the lung airway network, which is initiated and perpetuated by allergen-specific CD4+ T cells, IgE antibodies, and a massive release of Th2 cytokines.
Mohammad Afzal Khan
doaj   +1 more source

Surfactant and allergic airway inflammation

Swiss Medical Weekly, 2013
Pulmonary surfactant is a complex mixture of unique proteins and lipids that covers the airway lumen. Surfactant prevents alveolar collapse and maintains airway patency by reducing surface tension at the air-liquid interface. Furthermore, it provides a defence against antigen uptake by binding foreign particles and enhancing cellular immune responses ...
Carla Winkler, Jens Michael Hohlfeld
openaire   +3 more sources

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation [PDF]

, 2015
SummaryLung nociceptors initiate cough and bronchoconstriction. To elucidate if these fibers also contribute to allergic airway inflammation, we stimulated lung nociceptors with capsaicin and observed increased neuropeptide release and immune cell ...
Bruce D. Levy, Laedermann, Cedric, Agac, Busranour, Bruce P. Bean, Matthew DiBiase, Foster, S., Nader Ghasemlou, Foster, Simmie L., Simmie L. Foster, Oliver Haworth, Cronin, S., Maud A. Pascal, Von Hehn, C., Pascal, Maud A., Haworth, O., Levy, Bruce D., Pascal, M., Talbot, S., Woolf, Clifford J., Hiroyuki Seki, Clifford J. Woolf, Haworth, Oliver, Abdulnour, Raja-Elie E., Seki, Hiroyuki, Kuchroo, V., Roberson, David, Christian Von Hehn, Cronin, Shane J.F., Isaac M. Chiu, Lai, N., Patrick R. Burkett, Penninger, J., Ghasemlou, N., Von Hehn, Christian, Burkett, Patrick R., Chiu, I., Bean, Bruce P., Shane J.F. Cronin, Woolf, C., Lee, Seungkyu, Seungkyu Lee, Busranour Agac, Lee, S., Sébastien Talbot, Nicole Lai, Agac, B., Josef M. Penninger, Kuchroo, Vijay K., Burkett, P., Tran, Johnathan V., Ghasemlou, Nader, Raja-Elie E. Abdulnour, DiBiase, Matthew, DiBiase, M., Vijay K. Kuchroo, Seki, H., Laedermann, C., Johnathan V. Tran, Chiu, Isaac M., Abdulnour, R., Tran, J., Roberson, D., Levy, B., Talbot, Sébastien, Bean, B., David Roberson, Lai, Nicole, Penninger, Josef M., Cedric Laedermann   +68 more
core   +1 more source

Effects of the Immunomodulatory Agent Cordyceps militaris on Airway Inflammation in a Mouse Asthma Model

Pediatrics and Neonatology, 2008
Cordyceps militaris is a well-known fungus with immunomodulatory activity. It is generally used in traditional Chinese medicine to treat hemoptysis, bronchial or lung inflammation, and urogenital disorders.
Chia-Hsiu Hsu, Hai-Lun Sun, Ji-Nan Sheu, Min-Sho Ku, Chun-Ming Hu, You Chan, Ko-Huang Lue   +6 more
doaj   +1 more source