Results 31 to 40 of about 1,027,405 (258)

Randomized Controlled Trial of Fish Oil and Montelukast and Their Combination on Airway Inflammation and Hyperpnea-Induced Bronchoconstriction [PDF]

, 2010
Both fish oil and montelukast have been shown to reduce the severity of exercise-induced bronchoconstriction (EIB). The purpose of this study was to compare the effects of fish oil and montelukast, alone and in combination, on airway inflammation and ...
Louise A Turner, Turner Louise A., Mickleborough, Timothy D., Joel M Stager, Gregory S. Montgomery, Montgomery, Gregory, Tecklenburg-Lund, Sandra, Turner, Louise A., Montgomery, Gregory S., Alyce D. Fly, Joel M. Stager, Timothy D Mickleborough, Fly, Alyce D., Stager, Joel M., Fly, Alyce, Stager Joel M., Montgomery Gregory S., Mickleborough Timothy D., Timothy D. Mickleborough, Mickleborough, Timothy, Tecklenburg-Lund Sandra, Gregory S Montgomery, Stager, Joel, Louise A. Turner, Fly Alyce D., Turner, Louise, Sandra Tecklenburg-Lund, Alyce D Fly   +27 more
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Can HRCT be used as a marker of airway remodelling in children with difficult asthma? [PDF]

, 2006
BACKGROUND: Whole airway wall thickening on high resolution computed tomography (HRCT) is reported to parallel thickening of the bronchial epithelial reticular basement membrane (RBM) in adult asthmatics. A similar relationship in children with difficult
Khoo L, Khoo, L, Payne, DN, Hansell DM, Bush, A, Saglani S, Saglani, S, Ujita, M, Jeffery, PK, Papaioannou G, Jeffery PK, Bush A, Papaioannou, G, Owens, C, Hansell, DM, Owens C, Payne DN, Owens, CM, Ujita M   +18 more
core   +1 more source

Airway wall remodeling in asthma : novel mechanisms of human bronchial smooth muscle cells in the induction of angiogenesis [PDF]

, 2014
Asthma is a global major health concern and it affects estimated 300 million people. The prevalence of asthma is rising and there is no cure for asthma, only the symptoms can be controlled.
Keglowich, Laura Franziska
core   +1 more source

Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells

ERJ Open Research, 2018
Viral infections predispose to the development of childhood asthma, a disease associated with increased lung mast cells (MCs). This study investigated whether viral lower respiratory tract infections (LRTIs) can already evoke a MC response during ...
Cecilia K. Andersson, Medya Shikhagaie, Michiko Mori, Amal Al-Garawi, Jennifer L. Reed, Alison A. Humbles, Robert Welliver, Thais Mauad, Leif Bjermer, Manel Jordana, Jonas S. Erjefält   +10 more
doaj   +1 more source

Role of FK506-sensitive signals in asthmatic lung inflammation

Frontiers in Immunology, 2022
Asthma is airway inflammatory diseases caused by the activation of group 2 innate lymphoid cells (ILC2s) and type 2 helper T (TH2) cells. Cysteine proteases allergen cause tissue damage to airway epithelial cells and activate ILC2-mediated type 2 airway ...
Chihiro Tomiaki, Kosuke Miyauchi, Sewon Ki, Yoshie Suzuki, Narumi Suzuki, Hiroshi Morimoto, Yohei Mukoyama, Masato Kubo, Masato Kubo   +8 more
doaj   +1 more source

Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD) [PDF]

, 2006
Hypersecretion and chronic phlegm are major symptoms of chronic obstructive pulmonary disease (COPD) but animal models of COPD with a defined functional hypersecretion have not been established so far.
David A Groneberg, Wagner, Ulrich, Fischer, Axel, Groneberg, Jan David Alexander, Groneberg David A, Welte, Tobias, Fehmann Hans-Christoph, Staats Petra, Axel Fischer, Welte Tobias, Fischer Axel, Ulrich Wagner, Tobias Welte, Fehmann, Hans-Christoph, Petra Staats, Staats, Petra, Hans-Christoph Fehmann, Wagner Ulrich   +17 more
core   +1 more source

NETopathic Inflammation in Chronic Obstructive Pulmonary Disease and Severe Asthma

Frontiers in Immunology, 2019
Neutrophils play a central role in innate immunity, inflammation, and resolution. Unresolving neutrophilia features as a disrupted inflammatory process in the airways of patients with chronic obstructive pulmonary disease (COPD) and severe asthma.
Mohib Uddin, Mohib Uddin, Henrik Watz, Henrik Watz, Anna Malmgren, Frauke Pedersen, Frauke Pedersen, Frauke Pedersen   +7 more
doaj   +1 more source

Validation of the Human Ozone Challenge Model as a Tool for Assessing Anti-Inflammatory Drugs in Early Development [PDF]

, 2005
This study aimed to test the utility of the ozone challenge model for profiling novel compounds designed to reduce airway inflammation. The authors used a randomized, doubledummy, double-blind, placebo-controlled 3-period crossover design alternating ...
Vessey, Rupert S. J., Holz, Olaf, Rudolf A. Jörres, Kai Richter, Simpson, Kathy J., Tal-Singer, Ruth, Helgo Magnussen, Magnussen, Helgo, Anthony Gibson, Stanislawa Janicki, Kanniess, Frank, Richter, Kai, Ruth Tal-Singer, Gibson, Anthony, Kathy J. Simpson, Frank Kanniess, Janicki, Stanislawa, Rupert S. J. Vessey, Jörres, Rudolf A., Olaf Holz   +19 more
core   +1 more source

Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling [PDF]

, 2005
Background: Sub- epithelial extracellular matrix deposition is a feature of asthmatic airway remodelling associated with severity of disease, decline in lung function and airway hyperresponsiveness.
Reinhardt Alistair K, Robin J McAnulty, Reinhardt, AK, McAnulty Robin J, Geoffrey J Laurent, Laurent, GJ, Laurent Geoffrey J, Bottoms, SE, Bottoms Stephen E, McAnulty, RJ, Stephen E Bottoms, Alistair K Reinhardt   +11 more
core   +2 more sources

High-fat diet and palmitic acid amplify airway type 2 inflammation

Frontiers in Allergy, 2023
IntroductionMetabolic dysfunction such as elevated levels of saturated fatty acids (SFA) may play a role in obese asthma, but its contribution to airway inflammation remains unclear.
Kris Genelyn Dimasuay, Bruce Berg, Niccolette Schaunaman, Fernando Holguin, Daniel Winnica, Hong Wei Chu   +5 more
doaj   +1 more source