Results 81 to 90 of about 571,123 (210)

Elevated Expression of Serum Amyloid A 3 Protects Colon Epithelium Against Acute Injury Through TLR2-Dependent Induction of Neutrophil IL-22 Expression in a Mouse Model of Colitis

Frontiers in Immunology, 2018
Induced expression of serum amyloid A (SAA) is a hallmark of many inflammatory diseases, but whether SAA exacerbates inflammation or protects tissues against injury remains unclear. In dextran sulfate sodium (DSS)-induced colitis, SAA3 is the predominant
Gufang Zhang, Jin Liu, Lehao Wu, Lehao Wu, Yu Fan, Lei Sun, Feng Qian, Daijie Chen, Richard D. Ye, Richard D. Ye   +9 more
doaj   +1 more source

RhoH/TTF negatively regulates leukotriene production in neutrophils

, 2009
Leukotriene B(4) (LTB(4)) is an important proinflammatory lipid mediator generated by neutrophils upon activation. GM-CSF stimulation is known to enhance agonist-mediated LTB(4) production of neutrophils within minutes, a process called "priming".
Simon, Hans-Uwe, Dahinden, Clemens A, Schmidt-Mende, Jan, Daryadel, Arezoo, Troi, David, Ziemiecki, Andrew, Yousefi, Shida, Mordasini, Carlo, Schmid, Inès   +8 more
core   +1 more source

Preface

, 2011
Host defense to intracellular pathogens depends upon both innate and adaptive cell-mediated immune responses. Polymorphonuclear neutrophil leukocytes which belong to the innate immune system are the first cells that are recruited massively within hours ...
van Zandbergen, Ger, Fabienne Tacchini-Cottier, Tacchini-Cottier, Fabienne, Ger van Zandbergen   +3 more
core   +1 more source

Gut Microbiota Contributes to Resistance Against Pneumococcal Pneumonia in Immunodeficient Rag−/− Mice

Frontiers in Cellular and Infection Microbiology, 2018
Streptococcus pneumoniae causes infection-related mortality worldwide. Immunocompromised individuals, including young children, the elderly, and those with immunodeficiency, are especially vulnerable, yet little is known regarding S.
Krysta M. Felix, Ivan A. Jaimez, Thuy-Vi V. Nguyen, Thuy-Vi V. Nguyen, Heqing Ma, Walid A. Raslan, Christina N. Klinger, Kristian P. Doyle, Kristian P. Doyle, Hsin-Jung J. Wu, Hsin-Jung J. Wu   +10 more
doaj   +1 more source

Clofazimine, but Not Isoniazid or Rifampicin, Augments Platelet Activation in vitro

Frontiers in Pharmacology, 2018
Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, concerns remain about the cardiotoxic
Ronald Anderson, Ronald Anderson, Annette J. Theron, Jan G. Nel, Jan G. Nel, Chrisna Durandt, Chrisna Durandt, Moloko C. Cholo, Charles Feldman, Gregory R. Tintinger   +9 more
doaj   +1 more source

Neutrophils in Acute Coronary Syndrome

, 2017
Acute coronary syndrome (ACS) encompasses a spectrum of clinical disorders of myocardial ischaemia or infarction, with atherosclerosis leading to coronary plaque formation the predominant disease process.
Sanjay Patel, Rahul Kurup
core  

Expression, regulation, function and clinical significance of B7-H6 on neutrophils in human gastric cancer

Neoplasia: An International Journal for Oncology Research
Neutrophils are conspicuous components of gastric cancer (GC) tumors, increasing with tumor progression and poor patient survival. However, the phenotype, regulation, function and clinical relevance of neutrophils in human GC are presently unknown.
Pan Wang, Peng Zhu, Zheng-yan Li, Yong-liang Zhao, Fang-yuan Mao, Liu-sheng Peng, Shou-lu Luo, Ping Luo, Yu-gang Liu, Mao Chen, Yuan Zhuang   +10 more
doaj   +1 more source

Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells [PDF]

, 1990
HL-60 leukemic cells were differentiated along the neutrophilic pathway with retinoic acid (RA) or along the monocytic pathway with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).
Seifert, Roland, Jungblut, P. R.
core   +1 more source

Candida albicans-stimulated hematopoietic stem and progenitor cells generate trained neutrophils with enhanced mitochondrial ROS production that defend against infection.

PLoS Pathogens
Central trained immunity, induced via reprogramming of hematopoietic stem and progenitor cells (HSPCs), mediates sustained heightened responsiveness of mature myeloid cells to secondary challenges.
María Sobén, Paula Guerrero, Andrea Guiu, Alberto Yáñez, María Luisa Gil   +4 more
doaj   +1 more source

Olfactomedin-4+ neutrophils exacerbate intestinal epithelial damage in Clostridioides difficile infection

Infection and Immunity
Neutrophils are dominant cells during acute immune response to Clostridioides difficile infection (CDI). A higher number of infiltrating colonic neutrophils is clearly linked to greater tissue damage and severe CDI (3, 4).
S. Jose, A. Huber, A. Kassam, K. N. Weghorn, M. Powers-Fletcher, D. Sharma, A. Mukherjee, M. N. Alder, R. Madan   +8 more
doaj   +1 more source