Results 71 to 80 of about 761,815 (305)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Neutrophils isolated from systemic lupus erythematosus patients exhibit a distinct functional phenotype

Frontiers in Immunology
Neutrophil dysregulation, particularly of a low-density subset, is associated with systemic lupus erythematosus (SLE); however, the exact role of normal-density neutrophils in SLE remains unknown.
Neelakshi R. Jog, Catriona A. Wagner, Teresa Aberle, Eliza F. Chakravarty, Cristina Arriens, Joel M. Guthridge, Judith A. James, Judith A. James   +7 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A controversial role of neutrophils in tuberculosis infection pathogenesis

Инфекция и иммунитет, 2021
Tuberculosis (TB) continues to be an important and unresolved medical problem. About a quarter of mankind is infected with Mycobacterium tuberculosis, and about 5–10% of these people eventually develop TB.
I. A. Linge, A. S. Apt
doaj   +1 more source

Rheumatoid Arthritis Synovial Fluid Neutrophils Drive Inflammation Through Production of Chemokines, Reactive Oxygen Species, and Neutrophil Extracellular Traps

Frontiers in Immunology, 2020
Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting synovial joints. Neutrophils are believed to play an important role in both the initiation and progression of RA, and large numbers of activated neutrophils are found within both ...
H. L. Wright, M. Lyon, Elinor A Chapman, R. Moots, S. Edwards   +4 more
semanticscholar   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Neutrophils cultured ex vivo from CD34+ stem cells are immature and genetically tractable

Journal of Translational Medicine
Background Neutrophils are granulocytes with essential antimicrobial effector functions and short lifespans. During infection or sterile inflammation, emergency granulopoiesis leads to release of immature neutrophils from the bone marrow, serving to ...
Claire A. Naveh, Kiran Roberts, Przemysław Zakrzewski, Christopher M. Rice, Fernando M. Ponce-Garcia, Kathryn Fleming, Megan Thompson, Nawamin Panyapiean, Huan Jiang, Stephanie Diezmann, Pedro L. Moura, Ashley M. Toye, Borko Amulic   +12 more
doaj   +1 more source

Pro-inflammatory role of neutrophils populations in trauma patients: monitoring neutrophil populations

Frontiers in Immunology
BackgroundTrauma is a leading global cause of mortality, and systemic inflammatory response syndrome (SIRS) remains a significant complication, contributing to adverse outcomes.
Marcela Vlková, Marcela Vlková, Julie Štíchová, Julie Štíchová, Karolína Surá, Karolína Surá, Karolína Dvořáková, Karolína Dvořáková, Vojtěch Kunčický, Vojtěch Kunčický, Ioanna Papatheodorou, Ioanna Papatheodorou, Gabriela Blažková, Zuzana Tomášiková, Zuzana Tomášiková, Kamila Bendíčková, Kamila Bendíčková, Ludmila Dohnálková, Alexandra Mýtniková, Alexandra Mýtniková, Alexandra Mýtniková, Jan Žák, Jan Kovařík, Milan Krtička, Tomáš Tomáš, Vladimír Šrámek, Martin Helán, Martin Helán, Anna Kocurková, Anna Kocurková, Anna Kocurková, Jan Frič, Jan Frič, Jan Frič, Marcela Hortová-Kohoutková, Marcela Hortová-Kohoutková   +35 more
doaj   +1 more source

Understanding the role of neutrophils in acute respiratory distress syndrome

Biomedical Journal, 2020
Acute respiratory distress syndrome (ARDS) is difficult to treat and is associated with a high mortality rate. The most severe form of coronavirus disease 2019 (COVID-19) also leads to life-threatening ARDS.
Shun‐Chin Yang, Y. Tsai, Yen-Lin Pan, T. Hwang   +3 more
semanticscholar   +1 more source