ABSTRACT Cancer cells rely on citrate for multiple metabolic processes, suggesting that limiting the availability of extracellular citrate may represent a novel therapeutic strategy. The plasma membrane citrate transporter (pmCiC) has been implicated in the pathogenesis of several cancers before, and its activity can be inhibited by gluconate.
Konstantin Drexler +8 more
wiley +1 more source
Clinicopathological Spectrum of Nevus Lipomatosus Superficialis: Insights From a Single-Center Study. [PDF]
Mawlong AK +3 more
europepmc +1 more source
A recurrent mosaic mutation in SMO, encoding the hedgehog signal transducer smoothened, is the major cause of Curry-Jones syndrome [PDF]
et al,, Grange, Dorothy K
core +1 more source
Inflammatory niches as spatial drivers of disease mechanisms and targets for personalized treatment
This study provides a comprehensive review of how spatial transcriptomics reveals disease‐specific inflammatory niches across multiple skin disorders, highlighting key immune–stromal, neuro–immune and metabolic interactions that were previously unappreciated in non‐spatial analyses. Abstract Disease states are increasingly recognized as being shaped by
Rundong Jiang +3 more
wiley +1 more source
Surgical management and reconstruction techniques for divided eyelid nevus: a systematic review. [PDF]
Mahdood B +4 more
europepmc +1 more source
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive cancers, typically diagnosed at an advanced stage due to its subtle and often absent early symptoms. Despite representing only 3% of new cancer cases, it is projected to become the second leading cause of cancer‐related deaths by 2030.
Muhammad Masroor Hussain +5 more
wiley +1 more source
Near‐Infrared Spectroscopy Combined With Skin Impedance for Detection of Skin Cancer in Primary Care
Abstract Background The established method in primary care to distinguish skin cancer from benign lesions is clinical examination, with or without dermoscopy. The experience among primary care physicians in assessing skin tumours varies, as does the accessibility to teledermoscopy.
Maria Fragkou Dragka +2 more
wiley +1 more source
Proposed treatment options for combined nevi: report of two cases using combination therapy involving surgical excision and laser therapy. [PDF]
Nagai K, Yamagi Y, Mitsukawa N.
europepmc +1 more source
A Comparative Study of Melanocytic Tumours: Linking Portuguese Dogs and Cats to Human Cases
ABSTRACT Melanocytic tumours (MT) occur in both humans and companion animals, presenting an opportunity for comparative oncology research. Thus, this study provides a comprehensive epidemiological analysis comparing MT in Portuguese dogs, cats and humans. Data were obtained from the Portuguese National Cancer Registry (RON) (2011–2021) and Vet‐OncoNet (
Catarina Alves Pinto +5 more
wiley +1 more source

